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Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of 29\u00a0509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18\u00a0752 (63.6%)] showed that 15\u00a0678 (53.1%) had at least one comorbidity. Among 25\u00a0715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n\u2009=\u20093957). Adjusted odds of dying were significantly higher in age group \u226560\u2009years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6\u20137.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4\u20130.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3\u20130.7)] were protected from in-hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. 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