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The close anatomical relationship between endothelial cells and highly vascularized metabolic organs suggests that the crosstalk between these units is vital for systemic metabolic homeostasis. Here, we review recent studies about the pivotal role of endothelial cells in metabolic diseases. Specifically, we discuss how the dysfunction of endothelial cells directly contributes to the development of insulin resistance, type 2 diabetes mellitus, atherosclerosis and non-alcoholic fatty liver disease via communication with parenchymal cells. Furthermore, although many biological macromolecules have been shown to ameliorate the progression of metabolic diseases by improving endothelial function, the low solubility, poor bioavailability or lack of specificity of these molecules limit their clinical application. Given the advantages in drug delivery of nanomedicine, we focus on summarizing the reports that improving endothelial dysfunction through nanomedicine-based therapies provides an opportunity for preventing metabolic diseases.<\/jats:p>","DOI":"10.1093\/qjmed\/hcac210","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T13:12:09Z","timestamp":1662383529000},"page":"493-501","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic applications of nanomedicine in metabolic diseases by targeting the endothelium"],"prefix":"10.1093","volume":"116","author":[{"given":"L","family":"Hou","sequence":"first","affiliation":[{"name":"The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People\u2019s Hospital From the , Qingyuan, Guangdong 511518, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People\u2019s Hospital From the , Qingyuan, Guangdong 511518, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Liu","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People\u2019s Hospital From the , Qingyuan, Guangdong 511518, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Zhong","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People\u2019s Hospital From the , Qingyuan, Guangdong 511518, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangdong Eco-Engineering Polytechnic , 297 Guangshan First Road, Tianhe District , Guangzhou, Guangdong 510520, 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