{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:53:20Z","timestamp":1792155200688,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,24]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypoxia and hypercapnia due to acute pulmonary failure in patients with coronavirus disease 2019 (COVID-19) can increase the intracranial pressure (ICP). ICP correlated with the optic nerve sheath diameter (ONSD) on ultrasonography and is associated with a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the capability of ONSD measured during admission to the intensive care unit (ICU) in patients with critical COVID-19 in predicting in-hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 91 patients enrolled in the study were divided into two groups: survivor (n\u2009=\u200948) and nonsurvivor (n\u2009=\u200943) groups. ONSD was measured by ultrasonography within the first 3\u2009h of ICU admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median ONSD was higher in the nonsurvivor group than in the survivor group (5.95\u2009mm vs. 4.15\u2009mm, P\u2009&amp;lt;\u20090.001). The multivariate Cox proportional hazard regression analysis between ONSD and in-hospital mortality (contains 26 covariates) was significant (adjusted hazard ratio, 4.12; 95% confidence interval, 1.46\u201311.55; P\u2009=\u20090.007). The ONSD cutoff for predicting mortality during ICU admission was 5\u2009mm (area under the curve, 0.985; sensitivity, 98%; and specificity, 90%). The median survival of patients with ONSD &amp;gt;5\u2009mm (43%; n\u2009=\u200939) was lower than those with ONSD \u22645\u2009mm (57%; n\u2009=\u200952) (11.5\u2009days vs. 13.2\u2009days; log-rank test P\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ONSD ultrasonography during ICU admission may be an important, cheap and easy-to-apply method that can be used to predict mortality in the early period in patients with critical COVID-19.<\/jats:p><\/jats:sec>","DOI":"10.1093\/qjmed\/hcac242","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T13:34:58Z","timestamp":1666100098000},"page":"107-113","source":"Crossref","is-referenced-by-count":12,"title":["Optic nerve sheath diameter, intensive care unit admission and COVID-19-related-in-hospital 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