{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:18:56Z","timestamp":1782775136037,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,27]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals who suffered a neurological adverse event after the Coronavirus disease (COVID-19) vaccine could hesitate and defer reimmunization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We examine the risk of recurrence following reimmunization among patients who developed a neurological event after the first dose of the COVID-19 mRNA vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals who developed an adjudicated neurological adverse event (based on Brighton Collaboration criteria) within 6\u2009weeks of the first dose of the COVID-19 vaccine requiring hospitalization were enrolled into a multicenter national registry in Singapore. Neurological recurrence, defined by the development of another neurological event within 6\u2009weeks of the second vaccine dose, was reviewed. Clinical characteristics were compared between patients who chose to proceed or withhold further vaccination, and between those who received timely (3\u20136\u2009weeks) or delayed (&amp;gt;6\u2009weeks) reimmunization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 235 patients (median age, 67\u2009years; 63% men) who developed an adjudicated neurological event after their first dose of mRNA vaccine between 30 December 2020 and 20 April 2021, 181 (77%) chose to undergo reimmunization. Those who decided against reimmunization were older (median age, 74 vs. 66\u2009years) and had greater physical disability following their primary neurological event (46% vs. 20%, P\u2009&amp;lt;\u20090.001). Patients who suffered greater physical disability were three times more likely to delay their reimmunization (odds ratio 3.36, 95% confidence interval: 1.76\u20136.40). Neurological recurrence was observed in only four individuals (three with seizures and one with myasthenia gravis exacerbation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A prior neurological event should not necessarily preclude reimmunization and the decision to proceed with reimmunization should consider the overwhelming benefits conferred by vaccination toward ending this pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1093\/qjmed\/hcac251","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T17:15:27Z","timestamp":1668100527000},"page":"221-226","source":"Crossref","is-referenced-by-count":10,"title":["Low incidence of neurological recurrent side-effects following COVID-19 reimmunization"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-087X","authenticated-orcid":false,"given":"Jasmine Shimin","family":"Koh","sequence":"first","affiliation":[{"name":"From the Department of 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Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Y Q","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, National University Health System , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Hui","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute (Singapore General Hospital Campus) , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Che-Fai","family":"Hui","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Ng Teng Fong General Hospital , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian Ming","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of General Medicine, Changi General Hospital , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Pin","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sengkang General Hospital , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmyn","family":"Angon","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Khoo Teck Puat Hospital , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tan","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, National Neuroscience Institute (Tan Tock Seng Hospital Campus) , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy May Lin","family":"Quek","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, National University Health System , Singapore, Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of 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