{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:37:54Z","timestamp":1773326274088,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Guangdong Provincial Clinical Research Center for Cardiovascular Disease","award":["2020B111117011"],"award-info":[{"award-number":["2020B111117011"]}]},{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention","award":["2017B030314041"],"award-info":[{"award-number":["2017B030314041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Little evidence exists regarding the sex- and age-specific differences in the associations of comorbidities and incident heart failure (HF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aims to evaluate the sex- and age-specific associations of comorbidities and incident HF, and further calculate the population attributable fractions (PAFs) of comorbid diseases for HF by sex and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were from a sub-cohort of the Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project from Southern China. Participants were stratified by sex and age (&amp;lt;60 or \u226560). The seven comorbidities were collected at baseline, and the study outcome was HF-related hospitalization identified from the Inpatients Registry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 102\u2009278 participants (mean age: 54.3\u2009years, 60.5% were women) without prevalent HF were included. After a median follow-up of 3.5\u2009years, 1588 participants had incident HF. Men, older age (\u226560\u2009years) and most comorbidities were significantly associated with a higher risk of HF. The associations between several comorbidities with incident HF were more prominent in women and young participants aged &amp;lt;60 than in men and seniors. The seven comorbidities collectively explained a significant proportion of PAF for HF (47.1%, 95% confidence interval: 41.4, 52.2), and several sex- and age-specific differences in PAFs of comorbidities for incident HF were also observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this large, prospective cohort study, several sex- and age-specific differences in the associations between common comorbidities and incident HF were found among Chinese general adults, highlighting the importance of sex- and age-specific preventive strategies for HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaf080","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T15:48:41Z","timestamp":1743349721000},"page":"514-523","source":"Crossref","is-referenced-by-count":2,"title":["Sex- and age-specific differences in the associations between 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