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The primary outcome was the mean change from baseline in monthly migraine days (MMDs) during weeks 1\u20134.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>Of 343 patients screened, with 212 (mean age, 46.1 [SD 8.9] years; 162 [76.4%] female) were included in the intention-to-treat analyses. Baseline characteristics were cpmparable between groups. The TCM group demonstrated a significantly greater reduction in MMDs than the flunarizine group during both weeks 1\u20134 and weeks 5\u201316, with a difference of \u20130.64\u2009days (95% CI: \u20131.07 to \u20130.20; P\u2009=\u20090.004) during weeks 1\u20134. and \u20131.13\u2009days (95% CI: \u20131.48 to \u20130.78; P &amp;lt; 0.001) during weeks 5\u201316. These findings indicate that TCM is effective in preventing episodic migraine, with superior efficacy to flunarizine after 4\u2009weeks of treatment, and sustained benefits for 16\u2009weeks. TCM may therefore be considered an optional preventive therapy for episodic migraine without aura. These results support its use in patients unwilling to take, or unresponsive to, prophylactic drugs, and suggest its consideration in future clinical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaf210","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T11:55:35Z","timestamp":1757505335000},"page":"15-22","source":"Crossref","is-referenced-by-count":4,"title":["Traditional Chinese medicine versus flunarizine for the preventive treatment of episodic migraine: a randomized controlled clinical trial"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-5564","authenticated-orcid":false,"given":"Lu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation , 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