{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:53:23Z","timestamp":1784800403258,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Elite Medical Professionals Project of China-Japan Friendship Hospital","award":["ZRJY2023-GG02"],"award-info":[{"award-number":["ZRJY2023-GG02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteonecrosis of the femoral head (ONFH) is a serious and not uncommon complication in several autoimmune diseases. There is limited research and understanding of ONFH in idiopathic inflammatory myopathies (IIM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the prevalence, clinical characteristics and predictive factors of ONFH in IIM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>An observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively enrolled 1464 IIM patients, who were classified into ONFH and non-ONFH groups. Independent predictors of ONFH were identified by logistic regression and incorporated into a prediction model. Model performance was assessed using receiver operating characteristic curve, the Hosmer\u2013Lemeshow test, calibration curves and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of ONFH was 5.9% (86\/1464) in IIM. Notably, almost half (52.3%, 45\/86) tested positive for anti-melanoma-differentiation-associated gene 5 (MDA5) antibodies in patients with ONFH. Pulse or high-dose glucocorticoids (&amp;gt;1\u2009mg\/kg\/d) (G) (OR: 2.857, 95% CI: 1.769\u20134.613), anti-MDA5 antibodies (A) (OR: 3.546, 95% CI: 2.140\u20135.876), muscle weakness (M) (OR: 1.968, 95% CI: 1.154\u20133.356), periungual erythema (P) (OR: 2.198, 95% CI: 1.229\u20133.931) and hyperlipidemia (H) (OR: 4.784, 95% CI: 2.827\u20138.095) were identified as independent risk factors for ONFH. To better predict ONFH, a nomogram model was constructed, demonstrating good discrimination with an AUC of 0.798 (95% CI: 0.747\u20130.849). For rapid risk assessment, a simplified scoring model was developed and designated as \u2018GAMPH\u2019, with an AUC of 0.797 (95% CI: 0.747\u20130.848).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ONFH is not a rare complication of IIM, particularly among patients positive for anti-MDA5 antibodies. This study provides a promising clinical tool for identifying IIM patients at risk of developing ONFH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaf257","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:26:23Z","timestamp":1761222383000},"page":"216-222","source":"Crossref","is-referenced-by-count":2,"title":["High prevalence of osteonecrosis of the femoral head in anti-MDA5 antibody-positive dermatomyositis"],"prefix":"10.1093","volume":"119","author":[{"given":"Longyang","family":"Zhu","sequence":"first","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zong","sequence":"additional","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-6157","authenticated-orcid":false,"given":"Xiaoming","family":"Shu","sequence":"additional","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Peng","sequence":"additional","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochun","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University China-Japan Friendship School of Clinical Medicine , Beijing,","place":["China"]},{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-9307","authenticated-orcid":false,"given":"Yongpeng","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital , 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