{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:03:26Z","timestamp":1793754206570,"version":"4.6.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1705303"],"award-info":[{"award-number":["2018YFC1705303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3505301"],"award-info":[{"award-number":["2024YFC3505301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82374445"],"award-info":[{"award-number":["82374445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82405122"],"award-info":[{"award-number":["82405122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82305233"],"award-info":[{"award-number":["82305233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82575058"],"award-info":[{"award-number":["82575058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Hospital Development Center Foundation","award":["SHDC12025132"],"award-info":[{"award-number":["SHDC12025132"]}]},{"name":"CACMS Innovation Fund","award":["CI2023C018LH"],"award-info":[{"award-number":["CI2023C018LH"]}]},{"name":"Shanghai Oriental Talent Program for Top-notch Project","award":["BJWS2024046"],"award-info":[{"award-number":["BJWS2024046"]}]},{"name":"CACM Eaglet Program for Cultivating Young Clinical Talents in Chinese Medicine","award":["CYJH2024022"],"award-info":[{"award-number":["CYJH2024022"]}]},{"name":"2025 Shanghai Municipal Health Commission Seed Program for Medical New Technology Research and Translation","award":["2025ZZ1010"],"award-info":[{"award-number":["2025ZZ1010"]}]},{"name":"High-level Chinese Medicine Key Discipline Construction"},{"name":"Integrative Chinese and Western Medicine Clinic"},{"name":"National Administration of TCM","award":["zyyzdxk-2023065"],"award-info":[{"award-number":["zyyzdxk-2023065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis treatment still requires further exploration. Fire needle therapy, an external method used in traditional Chinese medicine (TCM), is considered to have a definite effect on psoriasis, but lacks high-level clinical evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the efficacy and safety of fire needle therapy for psoriasis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, single-blind, multicenter clinical trial was conducted in five large hospitals in China. In total, 78 patients with plaque psoriasis aged 18\u2009years or older were randomized to receive either fire needle therapy or control therapy over 4\u2009weeks, with a 4-week follow-up. The full analysis and intention-to-treat sets were used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After treatment, the Psoriasis Area and Severity Index (PASI) score in the fire needle therapy group was significantly lower (\u22121.15\u2009\u00b1\u20091.10 [95% confidence interval, CI: \u22121.51, \u22120.79] vs. \u22122.72\u2009\u00b1\u20092.15 [95% CI: \u22123.47, \u22121.97], P\u2009&amp;lt;\u20090.01), while the PASI50, PASI75 and PASI90 scores were substantially higher than those of the control group (77.14% vs. 42.11%, 57.14% vs. 21.05%, and 40.00% vs. 0%, P\u2009&amp;lt;\u20090.01). Fire needle therapy significantly improved the quality of life of patients with psoriasis (7.03\u2009\u00b1\u20094.01 [95% CI: 5.73, 8.33] vs. 3.66\u2009\u00b1\u20093.32 [95% CI: 2.50, 4.82], P\u2009&amp;lt;\u20090.05), with no adverse reactions. Further, there was no significant difference in recurrence rates between the two groups (0% vs. 6.06%, P\u2009&amp;gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fire needle therapy is an effective and safe treatment for plaque psoriasis which improves patient quality of life. These findings support its use and suggest that it can be recommended as a valuable treatment option in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaf275","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:57:01Z","timestamp":1762865821000},"page":"282-289","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of fire needle therapy for plaque psoriasis: a randomized, single-blind, multicenter clinical trial"],"prefix":"10.1093","volume":"119","author":[{"given":"Liu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine , Shanghai,","place":["China"]},{"name":"Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine , Shanghai,","place":["China"]},{"name":"Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ding","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shaanxi Hospital of Traditional Chinese Medicine , Xi\u2019an, Shannxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Song","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine , Harbin, Heilongjiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine , Nanchang, Jiangxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Ye","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Traditional Chinese Medicine Hospital of Shijiazhuang , Shijiazhuang, Hebei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine , Harbin, Heilongjiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine , Nanchang, Jiangxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-e","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Traditional Chinese Medicine Hospital of Shijiazhuang , Shijiazhuang, Hebei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ning","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shaanxi Hospital of Traditional Chinese Medicine , Xi\u2019an, Shannxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-9679","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine , Shanghai,","place":["China"]},{"name":"Institute of Dermatology, Shanghai Academy of 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