{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:54:37Z","timestamp":1781826877581,"version":"3.54.5"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Central nervous system (CNS) tuberculoma is a rare but severe form of tuberculosis (TB) that can mimic other neurological disorders and poses major diagnostic challenges, especially with drug resistance. We report a case of a woman in her 60s who developed CNS tuberculoma four years after completing anti-tuberculosis therapy (ATT) for pulmonary TB. She presented with progressive left-sided weakness, facial asymmetry, and dysphagia. MRI revealed a ring-enhancing lesion in the right caudate nucleus with a lipid-lactate peak on spectroscopy, consistent with tuberculoma. Drug susceptibility testing confirmed resistance to isoniazid and rifampicin, indicating multidrug-resistant TB (MDR-TB). A modified regimen with levofloxacin, ethionamide, and para-aminosalicylic acid led to neurological recovery. This case underscores the importance of considering CNS tuberculoma in patients with neurological deficits and prior TB, even after apparent cure. Early neuroimaging, drug resistance testing, and individualized therapy are vital to improving outcomes and reducing morbidity and mortality.<\/jats:p>","DOI":"10.1093\/qjmed\/hcaf310","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T13:14:18Z","timestamp":1764854058000},"page":"416-418","source":"Crossref","is-referenced-by-count":0,"title":["Case report: CNS tuberculoma in a patient with prior pulmonary tuberculosis"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8513-300X","authenticated-orcid":false,"given":"Shreya","family":"Mehta","sequence":"first","affiliation":[{"name":"Kasturba Medical College Manipal, Manipal Academy of Higher Education, 576104, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Mukhyaprana","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Manipal, Manipal Academy of Higher Education, Department of General Medicine , 576104, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Nayak M","sequence":"additional","affiliation":[{"name":"New York Presbyterian Brooklyn Methodist Hospital , Brooklyn, New York, 11215,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Suvarna","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Manipal, Manipal Academy of Higher Education, Department of Endocrinology , 576104, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"2026061819344665400_hcaf310-B1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ccm.2009.08.018","article-title":"Update on tuberculosis of the Central nervous system: pathogenesis, diagnosis, and treatment","volume":"30","author":"Thwaites","year":"2009","journal-title":"Clin Chest Med"},{"key":"2026061819344665400_hcaf310-B2","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00330-002-1608-7","article-title":"Tuberculosis of the Central nervous system: overview of neuroradiological findings","volume":"13","author":"Bernaerts","year":"2003","journal-title":"Eur Radiol"},{"key":"2026061819344665400_hcaf310-B3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1128\/CMR.00042-07","article-title":"Central nervous system tuberculosis: pathogenesis and clinical aspects","volume":"21","author":"Rock","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"2026061819344665400_hcaf310-B4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4103\/0028-3886.177608","article-title":"Neuroimaging in tuberculous meningitis","volume":"64","author":"Garg","year":"2016","journal-title":"Neurol India"},{"key":"2026061819344665400_hcaf310-B5","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00701-015-2501-x","article-title":"Surgery for brain tuberculosis: a review","volume":"157","author":"Rajshekhar","year":"2015","journal-title":"Acta Neurochir (Wien)"},{"key":"2026061819344665400_hcaf310-B6","volume-title":"Global Tuberculosis Report 2023","author":"World Health Organization","year":"2023"}],"container-title":["QJM: An International Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/qjmed\/advance-article-pdf\/doi\/10.1093\/qjmed\/hcaf310\/65780136\/hcaf310.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/qjmed\/article-pdf\/119\/5\/416\/65780136\/hcaf310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/qjmed\/article-pdf\/119\/5\/416\/65780136\/hcaf310.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:34:55Z","timestamp":1781825695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/qjmed\/article\/119\/5\/416\/8371927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":6,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,12,5]]},"published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/qjmed\/hcaf310","relation":{},"ISSN":["1460-2725","1460-2393"],"issn-type":[{"value":"1460-2725","type":"print"},{"value":"1460-2393","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,12,5]]}}}