{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:46:54Z","timestamp":1777924014881,"version":"3.51.4"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"DOI":"10.1093\/qjmed\/hcaf326","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:59:00Z","timestamp":1765976340000},"page":"342-344","source":"Crossref","is-referenced-by-count":0,"title":["Whole genome sequencing confirms reactivation of tuberculosis five years after initial infection despite adequate preventative therapy in a patient with profound immunosuppression"],"prefix":"10.1093","volume":"119","author":[{"given":"Emma","family":"McNally","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"School of Medicine, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarahjane","family":"O\u2019Riordan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, St James\u2019s Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Fitzgibbon","sequence":"additional","affiliation":[{"name":"Irish Mycobacteria Reference Laboratory, St James Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Roycroft","sequence":"additional","affiliation":[{"name":"Irish Mycobacteria Reference Laboratory, St James Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, St James\u2019s Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Haematology, St James\u2019s Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Keane","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"School of Medicine, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie","family":"Mclaughlin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"School of Medicine, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"2026050117062004000_hcaf326-B1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/infdis\/jiy579","article-title":"Anatomic and cellular niches for Mycobacterium tuberculosis in latent tuberculosis infection","volume":"219","author":"Mayito","year":"2019","journal-title":"J Infect Dis"},{"key":"2026050117062004000_hcaf326-B2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3389\/fonc.2019.01186","article-title":"Mechanisms underlying the anti-inflammatory and immunosuppressive activity of ruxolitinib","volume":"9","author":"Elli","year":"2019","journal-title":"Front Oncol"},{"key":"2026050117062004000_hcaf326-B3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00007691-199512000-00007","article-title":"Mode of action of tacrolimus (FK506): molecular and cellular mechanisms","volume":"17","author":"Thomson","year":"1995","journal-title":"Ther Drug Monit"},{"key":"2026050117062004000_hcaf326-B4","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s41598-017-01174-9","article-title":"Glucocorticoids suppress antimicrobial autophagy and nitric oxide production and facilitate mycobacterial survival in macrophages","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"2026050117062004000_hcaf326-B5","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1182\/blood.2019000823","article-title":"The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease","volume":"134","author":"Koyama","year":"2019","journal-title":"Blood"},{"key":"2026050117062004000_hcaf326-B6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1084\/jem.123.3.445","article-title":"Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissues","volume":"123","author":"McCune","year":"1966","journal-title":"J Exp Med"}],"container-title":["QJM: An International Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/qjmed\/advance-article-pdf\/doi\/10.1093\/qjmed\/hcaf326\/65946492\/hcaf326.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/qjmed\/article-pdf\/119\/4\/342\/65946492\/hcaf326.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/qjmed\/article-pdf\/119\/4\/342\/65946492\/hcaf326.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:06:30Z","timestamp":1777669590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/qjmed\/article\/119\/4\/342\/8382972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,17]]},"published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/qjmed\/hcaf326","relation":{},"ISSN":["1460-2725","1460-2393"],"issn-type":[{"value":"1460-2725","type":"print"},{"value":"1460-2393","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2025,12,17]]}}}