{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:05:41Z","timestamp":1783944341638,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC81370109"],"award-info":[{"award-number":["NSFC81370109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Asthma\u2013chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a new determinate syndrome whose exact characteristics remain unclear.<\/jats:p>\n                  <jats:p>Aim: The objective of this study is to find more difference between ACOS and COPD.<\/jats:p>\n                  <jats:p>Design: A retrospective study of ACOS and COPD in Chinese.<\/jats:p>\n                  <jats:p>Methods: Data from 65 patients with ACOS and 65 patients with COPD were retrospectively collected and analyzed. The basis of this study was to compare the two groups while ruling out differences in age, sex and smoking history.<\/jats:p>\n                  <jats:p>Results: Patients with ACOS tended to have earlier ages of onset, longer durations of symptoms, better nutritional status, higher single-breath diffusing capacity of carbon monoxide (DLCO) %predicted and airway resistance %predicted, more exacerbations in the preceding 12 months and shorter lengths of hospitalization. DLCO %predicted, airway resistance %predicted, and length of hospitalization were the variables most significantly associated with the presence of ACOS in patients with COPD. ROC correlating airway resistance %predicted value and current ACOS showed an optimal cutoff of airway resistance %predicted of over 296.6. During follow-up (median: 45 months; interquartile range: 6\u201382 months), 16 patient deaths were recorded (3 patients with ACOS). The risk remained significantly higher in patients with COPD alone than in patients with ACOS (HR 3.932; 95% CI 1.083\u201319.755; P\u2009=\u20090.046).<\/jats:p>\n                  <jats:p>Conclusion: Patients with ACOS were more likely to have better prognoses and lower mortality than those with COPD alone, though with greater exacerbation frequency.<\/jats:p>","DOI":"10.1093\/qjmed\/hcx005","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T13:03:22Z","timestamp":1483707802000},"page":"431-436","source":"Crossref","is-referenced-by-count":8,"title":["Asthma\u2013COPD overlap syndrome showed more exacerbations however lower mortality than COPD"],"prefix":"10.1093","volume":"110","author":[{"given":"J.-W.","family":"Bai","sequence":"first","affiliation":[{"name":"From the 1Departments of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mao","sequence":"additional","affiliation":[{"name":"From the 1Departments of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-L.","family":"Yang","sequence":"additional","affiliation":[{"name":"2Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Liang","sequence":"additional","affiliation":[{"name":"From the 1Departments of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-W.","family":"Lu","sequence":"additional","affiliation":[{"name":"From the 1Departments of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-F.","family":"Xu","sequence":"additional","affiliation":[{"name":"From the 1Departments of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"2026071307100624000_hcx005-B1","first-page":"861926.","article-title":"The asthma-COPD overlap syndrome: a common clinical problem in the elderly","volume":"2011","author":"Zeki","year":"2011","journal-title":"J Allergy (Cairo)"},{"key":"2026071307100624000_hcx005-B2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1378\/chest.10-2974","article-title":"Bronchodilator reversibility in COPD","volume":"140","author":"Hanania","year":"2011","journal-title":"Chest"},{"key":"2026071307100624000_hcx005-B3","year":"2015"},{"key":"2026071307100624000_hcx005-B4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1378\/chest.15-1055","article-title":"Defining the asthma-COPD overlap syndrome in a COPD cohort","volume":"149","author":"Cosio","year":"2016","journal-title":"Chest"},{"key":"2026071307100624000_hcx005-B5","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2147\/COPD.S88274","article-title":"Biomarker-based detection of asthma-COPD overlap syndrome in COPD populations","volume":"10","author":"Tamada","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026071307100624000_hcx005-B6","first-page":"1745","article-title":"Is a previous diagnosis of asthma a reliable criterion for asthma-COPD overlap syndrome in a patient with COPD?","volume":"10","author":"Barrecheguren","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026071307100624000_hcx005-B7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1183\/13993003.00436-2016","article-title":"What is asthma-COPD overlap syndrome? 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