{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:14:26Z","timestamp":1789773266863,"version":"4.0.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Besides peripheral cytopenias, bone marrow abnormalities, such as fibrosis, pure red cell aplasia and aplastic anemia have been reported in patients with systemic lupus erythematosus (SLE), suggesting that bone marrow may be a 25 target organ in SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Our objective was to describe this bone marrow involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This registry is a nationwide retrospective study. Centers provided data concerning medical history, SLE manifestations, type of hematologic disorder, treatments and outcome. Bone marrow aspirations and\/or biopsies were transferred for centralized review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty patients from 19 centers were included. Central hematologic manifestations comprised bone marrow fibrosis (n\u2009=\u200917; 57%), pure red cell aplasia (n\u2009=\u20098; 27%), myelodysplastic syndrome (n\u2009=\u20093; 10%), aplastic anemia and agranulocytosis (n\u2009=\u20091; 3% each). Bone marrow involvement was diagnosed concomitantly with SLE in 12 patients. Bone marrow biopsies showed fibrosis in 19 cases, including one case of pure red cell aplasia and one case of agranulocytosis and variable global marrow cellularity. Treatments included corticosteroids (90%), hydroxychloroquine (87%), rituximab (33%), intravenous immunoglobulins (30%), mycophenolate mofetil (20%) and ciclosporine (20%). After a median follow-up of 27\u2009months (range: 1\u2013142), 24 patients manifested complete improvement. No patient died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This registry comprises the largest series of SLE patients with bone marrow involvement. It demonstrates the strong link between SLE and bone marrow fibrosis. Patients with atypical or refractory cytopenia associated with SLE should undergo bone marrow examination to enable appropriate, and often effective, treatment. Long-term prognosis is good.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/qjmed\/hcx102","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T15:13:27Z","timestamp":1495034007000},"page":"701-711","source":"Crossref","is-referenced-by-count":17,"title":["Bone marrow involvement in systemic lupus erythematosus"],"prefix":"10.1093","volume":"110","author":[{"given":"E","family":"Chalayer","sequence":"first","affiliation":[{"name":"From the Clinical Investigation Center-CIC 1408, CHU Saint Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Costedoat-Chalumeau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, AP-HP, Referral Center for Rare Auto-Immune and Systemic Diseases, Cochin Hospital, Paris, France"},{"name":"Paris Descartes-Sorbonne Paris Cit\u00e9 University, Paris, France"},{"name":"INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Beyne-Rauzy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ninet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Edouard Herriot, Centre Hospitalier Universitaire de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Durupt","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tebib","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, 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