{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:30:06Z","timestamp":1740130206699,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academia Sinica Stroke Biosignature Project"},{"name":"MOST Clinical Trial Consortium"},{"name":"Tseng-Lien Lin Foundation"},{"name":"Kiyo Aoshima Memorial Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Central venous catheter (CVC) placement is a common procedure used for the treatment of critically ill patients. However, ischemic stroke is a complication after CVC placement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study investigated the association between CVC placement and ischemic stroke risk in an Asian population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Population-based retrospective study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 37\u00a0623 patients who ever-received CVC placement over 2000\u201310 and propensity score-matched individuals without CVC placement as the comparison cohort from the Taiwan National Health Insurance Research Database. We determined the cumulative incidence rates and adjusted hazard ratios (aHRs) for ischemic stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We finally identified and enrolled 34\u00a0164 propensity score-matched pairs of individuals. Compared with the comparison group, CVC placement increased the average annual ischemic stroke incidence [19.5 vs. 11.6 per 10\u00a0000 person-years; crude HR=1.28, 95%, confidence interval (CI)=1.21\u20131.35; adjusted subhazard ratio (aSHR)=1.4, 95% CI = 1.33\u20131.47; P&lt;0.001). In addition, compared with those aged &gt;35\u2009years, stroke risk was significantly higher in &lt;35-year-old patients with CVC placement (aSHR=14.3, 95% CI=6.11\u201333.4; P&lt;0.001). After &lt;1-year follow-up, the ischemic stroke incidence rate in the CVC placement group was \u223c3.25-fold higher than that in the comparison group (aHR=3.25, 95% CI=2.9\u20133.63; P&lt;0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CVC placement increases ischemic stroke risk, particularly in those aged \u226435\u2009years; this trend warrants further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/qjmed\/hcz152","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T23:14:30Z","timestamp":1560381270000},"page":"771-778","source":"Crossref","is-referenced-by-count":5,"title":["Central venous catheter use increases ischemic stroke risk: a nationwide population-based study"],"prefix":"10.1093","volume":"112","author":[{"given":"P -H","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Tungs Taichung Metro Harbor Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C -Y","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Emergency Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C -H","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tungs Taichung Metro Harbor Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y -C","family":"Su","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung, Taiwan"},{"name":"Health Data Management Office, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C -W","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Emergency 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