{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:39:02Z","timestamp":1760647142739},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Currently, there is a shortfall in the number of suitable organs available for transplant resulting in a high number of patients on the active transplant waiting lists worldwide. To address this shortfall and increase the utilization of donor organs, the acceptance criteria for donor organs is gradually expanding including increased use of organs from donation after circulatory death. Use of such extended criteria donors and exposure of organs to more prolonged periods of warm or cold ischaemia also increases the risk of primary graft dysfunction occurring. Normothermic machine perfusion (NMP) offers a unique opportunity to objectively assess donor organ function outside the donor body and potentially recondition those deemed unsuitable on initial evaluation prior to implantation in the recipient. Furthermore, NMP provides a platform to support the use of established and novel therapeutics delivered directly to the organ, without the need to worry about potential deleterious \u2018off-target\u2019 side effects typically considered when treating the whole patient. This review will explore some of the novel therapeutics currently being added to perfusion platforms during NMP experimentally in an attempt to improve organ function and post-transplant outcomes.<\/jats:p>","DOI":"10.1093\/qjmed\/hcz321","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T12:24:00Z","timestamp":1578572640000},"page":"650-657","source":"Crossref","is-referenced-by-count":4,"title":["Maximizing organs for donation: the potential for <i>ex situ<\/i> normothermic machine perfusion"],"prefix":"10.1093","volume":"116","author":[{"given":"C","family":"Griffiths","sequence":"first","affiliation":[{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Institute of Transplantation, Freeman Hospital From the , Newcastle Upon Tyne, NE7 7DN, UK"},{"name":"Translational and Clinical Research Institute, Newcastle University , Newcastle Upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"W E","family":"Scott","sequence":"additional","affiliation":[{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Institute of Transplantation, Freeman Hospital From the , Newcastle Upon Tyne, NE7 7DN, UK"},{"name":"Translational and Clinical Research Institute , Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ali","sequence":"additional","affiliation":[{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Institute of Transplantation From the , Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, UK"},{"name":"Translational and Clinical Research Institute, Newcastle University , Newcastle Upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Fisher","sequence":"additional","affiliation":[{"name":"NIHR Blood 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