{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:31:13Z","timestamp":1791487873690,"version":"4.3.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB027061"],"award-info":[{"award-number":["P41 EB027061"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB034575"],"award-info":[{"award-number":["R01EB034575"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"name":"7 Tesla Terra Instrument","award":["S10 OD025256"],"award-info":[{"award-number":["S10 OD025256"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medial meniscus root tears often lead to knee osteoarthritis. The extent of meniscal tissue changes beyond the localized root tear is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate if 7 Tesla 3D T2*-mapping can detect intrasubstance meniscal degeneration in patients with arthroscopically verified medial meniscus posterior root tears (MMPRTs), and assess if tissue changes extend beyond the immediate site of the posterior root tear detected on surface examination by arthroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study we acquired 7\u2009T knee MRIs from patients with MMPRTs and asymptomatic controls. Using a linear mixed model, we compared T2* values between patients and controls, and across different meniscal regions. Patients underwent arthroscopic assessment before MMPRT repair. Changes in pain levels before and after repair were calculated using Knee Injury &amp; Osteoarthritis Outcome Score (KOOS). Pain changes and meniscal extrusion were correlated with T2* using Pearson correlation (r).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty patients (mean age 53\u2009\u00b1\u20098; 16 females) demonstrated significantly higher T2* values across the medial meniscus (anterior horn, posterior body and posterior horn: all P\u2009&amp;lt;\u2009.001; anterior body: P\u2009=\u2009.007), and lateral meniscus anterior (P\u2009=\u2009.024) and posterior (P\u2009&amp;lt;\u2009.001) horns when compared to the corresponding regions in ten matched controls (mean age 53\u2009\u00b1\u200912; 8 females). Elevated T2* values were inversely correlated with the change in pain levels before and after repair. All patients had medial meniscal extrusion of \u22652\u2009mm. Arthroscopy did not reveal surface abnormalities in 70% of patients (14 out of 20).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated T2* values across both medial and lateral menisci indicate that degenerative changes in patients with MMPRTs extend beyond the immediate vicinity of the posterior root tear. This suggests more widespread meniscal degeneration, often undetected by surface examinations in arthroscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/radadv\/umae005","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T08:55:47Z","timestamp":1710838547000},"source":"Crossref","is-referenced-by-count":16,"title":["Seven tesla knee MRI T2*-mapping detects intrasubstance meniscus degeneration in patients with posterior root tears"],"prefix":"10.1093","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8134","authenticated-orcid":false,"given":"Abdul Wahed","family":"Kajabi","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160tefan","family":"Zb\u00fd\u0148","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44196, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse S","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Diagnostic Radiology, Oregon Health & Science University, Portland, OR, 97239, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisa","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Knutsen","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke V","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Twin Cities Orthopedics, Edina, MN, 55435, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Homan","sequence":"additional","affiliation":[{"name":"Twin Cities Orthopedics, Edina, MN, 55435, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Abbasguliyev","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Ataturk University Research Hospital, Erzurum, 25240, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor J","family":"Metzger","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"LaPrade","sequence":"additional","affiliation":[{"name":"Twin Cities Orthopedics, Edina, MN, 55435, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta M","family":"Ellermann","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States"},{"name":"Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"13","key":"2024051416005226100_umae005-B1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/bjsports-2017-098942","article-title":"Meniscal root tears: a silent epidemic","volume":"52","author":"Cinque","year":"2018","journal-title":"Br J Sports Med"},{"issue":"12","key":"2024051416005226100_umae005-B2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.5435\/JAAOS-D-19-00102","article-title":"Meniscal root injuries","volume":"28","author":"Krych","year":"2020","journal-title":"J Am Acad Orthop Surg"},{"issue":"2","key":"2024051416005226100_umae005-B3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/0363546520976635","article-title":"Functional, magnetic resonance imaging, and second-look arthroscopic outcomes after pullout repair for avulsion tears of the posterior lateral meniscus root","volume":"49","author":"Zhuo","year":"2021","journal-title":"Am J Sports Med"},{"issue":"5","key":"2024051416005226100_umae005-B4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00402-021-03870-8","article-title":"Correlation of factors affecting correction of meniscal extrusion and outcome after medial meniscus root repair","volume":"142","author":"Sundararajan","year":"2022","journal-title":"Arch Orthop Trauma Surg"},{"issue":"14","key":"2024051416005226100_umae005-B5","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1177\/03635465211052526","article-title":"The reliability of 3-T magnetic resonance imaging to identify arthroscopic features of meniscal tears and its utility to predict meniscal tear reparability","volume":"49","author":"Strawbridge","year":"2021","journal-title":"Am J Sports Med"},{"issue":"4 Suppl 3","key":"2024051416005226100_umae005-B6","first-page":"153","article-title":"Prediction of reparability of meniscal tears in athletes using magnetic resonance","volume":"34","author":"Goes","year":"2020","journal-title":"J Biol Regul Homeost Agents"},{"issue":"2","key":"2024051416005226100_umae005-B7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2020.100061","article-title":"Relating MR relaxation times of ex vivo meniscus to tissue degeneration through comparison with histopathology","volume":"2","author":"Einarsson","year":"2020","journal-title":"Osteoarthr Cartil Open"},{"issue":"3","key":"2024051416005226100_umae005-B8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2018.12.003","article-title":"Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci","volume":"27","author":"Olsson","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"2024051416005226100_umae005-B9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.joca.2012.01.009","article-title":"UTE-T2 mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear","volume":"20","author":"Williams","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"2024051416005226100_umae005-B10","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00256-021-03808-6","article-title":"Quantitative magnetic resonance imaging of meniscal pathology ex vivo","volume":"50","author":"Bae","year":"2021","journal-title":"Skeletal Radiol"},{"issue":"2","key":"2024051416005226100_umae005-B11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/BF01476474","article-title":"McMurray's test tested","volume":"2","author":"Corea","year":"1994","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2024051416005226100_umae005-B12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1477-7525-1-64","article-title":"The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis","volume":"1","author":"Roos","year":"2003","journal-title":"Health Qual Life Outcomes"},{"issue":"9","key":"2024051416005226100_umae005-B13","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.joca.2011.05.008","article-title":"Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis","volume":"19","author":"Pauli","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"2024051416005226100_umae005-B14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5704\/MOJ.1507.013","article-title":"Meniscal extrusion in the knee: should only 3 mm extrusion be considered significant? An assessment by MRI and arthroscopy","volume":"9","author":"Muzaffar","year":"2015","journal-title":"Malays Orthop J"},{"issue":"6","key":"2024051416005226100_umae005-B15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.joca.2012.02.011","article-title":"Repeated measurements, bilateral observations and pseudoreplicates, why does it matter?","volume":"20","author":"Ranstam","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"2024051416005226100_umae005-B16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.11613\/BM.2015.015","article-title":"Understanding Bland Altman analysis","volume":"25","author":"Giavarina","year":"2015","journal-title":"Biochem Med (Zagreb)"},{"issue":"2","key":"2024051416005226100_umae005-B17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"issue":"2","key":"2024051416005226100_umae005-B18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/mrm.27443","article-title":"Orientation dependence and decay characteristics of T(2) relaxation in the human meniscus studied with 7 Tesla MR microscopy and compared to histology","volume":"81","author":"Hager","year":"2019","journal-title":"Magn Reson Med"},{"issue":"7","key":"2024051416005226100_umae005-B19","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1177\/0363546519844250","article-title":"Utilization of transtibial centralization suture best minimizes extrusion and restores tibiofemoral contact mechanics for anatomic medial meniscal root repairs in a cadaveric model","volume":"47","author":"Daney","year":"2019","journal-title":"Am J Sports Med"},{"issue":"7","key":"2024051416005226100_umae005-B20","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00167-021-06747-w","article-title":"ICRS scores worsen between 2-year short term and 5-year mid-term follow-up after transtibial medial meniscus root repair despite maintained functional outcomes","volume":"30","author":"Kaplan","year":"2022","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"3","key":"2024051416005226100_umae005-B21","doi-asserted-by":"crossref","first-page":"2325967120905529","DOI":"10.1177\/2325967120905529","article-title":"Predictive factors for failure of meniscal repair: a retrospective dual-center analysis of 918 consecutive cases","volume":"8","author":"Ronnblad","year":"2020","journal-title":"Orthop J Sports Med"},{"issue":"14","key":"2024051416005226100_umae005-B22","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2106\/JBJS.21.01303","article-title":"Meniscal repair outcomes at greater than 5 years: a systematic review and meta-analysis","volume":"104","author":"Nepple","year":"2022","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"2024051416005226100_umae005-B23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/RLI.0000000000000303","article-title":"Comparison of routine knee magnetic resonance imaging at 3 T and 7 T","volume":"52","author":"Springer","year":"2017","journal-title":"Invest Radiol"},{"issue":"9","key":"2024051416005226100_umae005-B24","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1007\/s00330-012-2450-1","article-title":"Magnetic resonance imaging of the knee at 3 and 7 tesla: a comparison using dedicated multi-channel coils and optimised 2D and 3D protocols","volume":"22","author":"Welsch","year":"2012","journal-title":"Eur Radiol"},{"issue":"7","key":"2024051416005226100_umae005-B25","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/RLI.0000000000000456","article-title":"Assessment of low-grade meniscal and cartilage damage of the knee at 7 T: a comparison to 3 t imaging with arthroscopic correlation","volume":"53","author":"Friebe","year":"2018","journal-title":"Invest Radiol"}],"container-title":["Radiology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/radadv\/advance-article-pdf\/doi\/10.1093\/radadv\/umae005\/57237345\/umae005.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/radadv\/article-pdf\/1\/1\/umae005\/57599411\/umae005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/radadv\/article-pdf\/1\/1\/umae005\/57599411\/umae005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:16:16Z","timestamp":1731582976000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/radadv\/article\/doi\/10.1093\/radadv\/umae005\/7630766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,5,14]]}},"URL":"https:\/\/doi.org\/10.1093\/radadv\/umae005","relation":{},"ISSN":["2976-9337"],"issn-type":[{"value":"2976-9337","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,1]]},"published":{"date-parts":[[2024,3,19]]},"article-number":"umae005"}}