{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:33:32Z","timestamp":1784255612373,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["10003604"],"award-info":[{"award-number":["10003604"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With chronic liver disease (CLD) rising globally, noninvasive methods are needed to stratify early, intermediate, and advanced CLD with and without clinically significant portal hypertension (CSPH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze the combined diagnostic value of intravoxel incoherent motion (IVIM) and liver stiffness (LS) from magnetic resonance elastography (MRE) for CLD stage discrimination vs secondary single-parameter analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study included 185 patients who underwent 3T liver MRI, including MRE and IVIM, between March 2016 and November 2023. Patients with CLD were grouped based on their liver fibrosis degree into early CLD (F0-F1; n\u2009=\u200921), intermediate CLD (F2; n\u2009=\u200919), advanced CLD (F3-F4, n\u2009=\u200920), and advanced CLD with CSPH (n\u2009=\u200922). CSPH was defined as splenomegaly (&amp;gt;120\u2009mm) with thrombocytopenia (&amp;lt;100 \u00d7 109\/L), ascites, or portosystemic collaterals. Patients without CLD (n\u2009=\u2009103) served as negative controls. IVIM parameters (tissue diffusivity D, perfusion fraction f, and pseudo-diffusion coefficient D*) and MRE LS were analyzed. Statistical analysis included the Kruskal-Wallis test and both univariate and multivariate regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 185 patients (median age: 55\u2009years, interquartile range 25%-75%: 45-63\u2009years; 94 men) were evaluated. All parameters differed significantly between all groups (P &amp;lt; .001). f and D* decreased with disease progression, while LS increased. D initially decreased in patients with CLD but increased in those with CSPH. Consequently, higher D-values indicated the presence of CSPH in advanced stages (odds ratio [OR] 1.09, 95% CI 1.03-1.17, P = .009). Elevated LS values showed strong associations with the presence of CLD (OR 5.01, CI 2.25-12.65, P &amp;lt; .001). Combining D and LS further improved diagnostic differentiation between disease stages, especially for differentiation between advanced CLD and advanced CLD with CSPH (OR 2.41, CI 1.33-5.44, P = .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IVIM and MRE are useful for characterizing CLD and CSPH. Combining D from IVIM with LS from MRE improves diagnostic accuracy compared to MRE alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/radadv\/umaf039","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:56:45Z","timestamp":1763038605000},"source":"Crossref","is-referenced-by-count":1,"title":["Detection and severity stratification of chronic liver disease using magnetic resonance intravoxel incoherent motion and elastography"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-3181","authenticated-orcid":false,"given":"Damiano","family":"Catucci","sequence":"first","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital Bern , Bern, 3010,","place":["Switzerland"]},{"name":"Graduate School for Health Sciences, University of Bern , Bern, 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