{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:04:00Z","timestamp":1773266640840,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hong Kong Health and Medical Research Fund","award":["HMRF18190051"],"award-info":[{"award-number":["HMRF18190051"]}]},{"name":"CUHK DIIR MRI Facility"},{"name":"Kai Chong Tong"},{"name":"HKSAR Research Matching Grant Scheme"},{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Synovitis is the key inflammatory feature of rheumatoid arthritis (RA). Quantitative assessment of synovitis better correlates with patient outcomes than semiquantitative assessment but it is time-consuming.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop and validate an automated model for segmentation and quantification of wrist synovial tissue volume on postcontrast fat-suppressed T1-weighted MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Patients with early RA (symptoms for \u226424\u2009months) at a single center were recruited at baseline and were followed up at year 1 and year 8. Postcontrast axial fat-suppressed T1-weighted images of the most symptomatic wrist were acquired at 3.0\u2009T. One observer manually segmented consecutive synovitis areas on all MRI datasets. A framework, based on the convolutional neural network, nnU-Net, was trained and validated (5-fold cross-validation with image level splits) with 295 image datasets used for model training and validation. The rheumatoid arthritis MRI score was used to semiquantitatively grade synovitis. Manually segmented synovial volume by a single reader was used as the reference standard. Forty-five external image datasets from 2 different imaging centers were used to test generalizable applicability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For automated synovitis segmentation, the overall S\u00f8rensen-Dice similarity coefficient (DSC) was 0.75\u2009\u00b1\u20090.11 (mean \u00b1 SD) compared to manual segmentation. Higher DSC values were found in patients with moderate (0.80\u2009\u00b1\u20090.06) and severe (0.84\u2009\u00b1\u20090.05) degrees of synovitis. The model had a similar performance with externally acquired data (DSC value: 0.70\u2009\u00b1\u20090.20). Predicted and manually segmented synovitis volume measurements showed excellent agreement (Pearson correlation: r\u2009=\u20090.975, P\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A fully automated model quantified wrist synovial tissue volume with good agreement to manual reference and maintained performance on external data, supporting potential use in clinical studies and prospective evaluation in practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/radadv\/umag004","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:34:16Z","timestamp":1768739656000},"source":"Crossref","is-referenced-by-count":0,"title":["nnUnet-based automated quantification of wrist joint synovitis volume in patients with rheumatoid arthritis: a feasibility study"],"prefix":"10.1093","volume":"3","author":[{"given":"Bingjing","family":"Zhou","sequence":"first","affiliation":[{"name":"The Chinese University of Hong Kong Department of Imaging and Interventional Radiology, , Hong Kong, 999077,","place":["China"]},{"name":"The Chinese University of Hong Kong CU Lab for AI in Radiology (CLAIR), , Hong Kong, 999077,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-1069","authenticated-orcid":false,"given":"Su","family":"Wu","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Department of Imaging and Interventional Radiology, , Hong Kong, 999077,","place":["China"]},{"name":"The Chinese University of Hong Kong CU Lab for AI in Radiology (CLAIR), , Hong Kong, 999077,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5206-9382","authenticated-orcid":false,"given":"James Francis","family":"Griffith","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Department of Imaging and Interventional Radiology, , Hong Kong, 999077,","place":["China"]},{"name":"The Chinese University of Hong Kong CU Lab for AI in Radiology (CLAIR), , Hong Kong, 999077,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3766-6917","authenticated-orcid":false,"given":"Fan","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Department of Imaging and Interventional Radiology, , Hong Kong, 999077,","place":["China"]},{"name":"The Chinese University of Hong Kong CU Lab for AI in Radiology (CLAIR), , Hong Kong, 999077,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3138-361X","authenticated-orcid":false,"given":"Miaoru","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Department of Imaging and Interventional Radiology, , Hong Kong, 999077,","place":["China"]},{"name":"The Chinese University of Hong Kong CU Lab for AI in Radiology (CLAIR), , Hong Kong, 999077,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Radiology, , Tokyo, 1638001,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai-Shan","family":"Tam","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Department of Medicine & Therapeutics, , Hong Kong, 999077,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"issue":"10416","key":"2026031102000280900_umag004-B1","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"issue":"5","key":"2026031102000280900_umag004-B2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00256-019-03179-z","article-title":"MRI and ultrasound of the hands and wrists in rheumatoid arthritis. 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