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While cardiac MRI is the preferred modality for staging the severity of tissue injury, conventional scan protocols require long acquisition times with multiple breath-held and ECG-gated acquisitions, limiting its utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop a free-breathing, whole-heart, non-ECG gated cardiac MRI for staging irreversible tissue injury in MI that can be completed in &amp;lt;20 minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A fast cardiac MRI (Biograph, Siemens Healthcare, 3\u2009T) method based on a low-rank tensor framework was developed (reconstruction performed in MATLAB) and tested against the conventional approach using a pre-clinical canine model of reperfused MI (n\u2009=\u200915) with histological validation. Each subject underwent 2 exams that were randomized 2 days apart (day 6-8 post MI, respectively). Correlations between the proposed and conventional methods and left-ventricular ejection fraction (LVEF), MI size and transmurality, size of microvascular obstruction (MVO), and intramyocardial hemorrhage (IMH) volumes were assessed using linear regression and Bland-Altman analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve out of 15 subjects survived the initial reperfusion injury. The proposed method reduced acquisition time by &amp;gt;50%. The cardiac MRI evidence of tissue injury was confirmed on histopathology in all cases. The agreements between the proposed and conventional methods for LVEF, MI volume, persistent MVO volume and IMH volume were excellent; limits of agreement (LoA) were \u22122.1%-1.8%, \u22122.9%-3.3%, \u22122.4%-4.1%, and \u22121.5%-1.5%, respectively. MI transmurality and early MVO showed good agreement; LoA were \u22126.8%-9.7% and \u22126.6%-8.2%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed free-breathing, whole-heart, non-ECG gated cardiac MRI approach permits accurate determination of tissue injury in a canine model with &amp;gt;2-fold reduction in scan time. While the method remains to be tested in patients, it has the potential to facilitate efficient use of cardiac MRI for staging the severity of tissue injury in patients with reperfused MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/radadv\/umag009","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:37:26Z","timestamp":1776339446000},"source":"Crossref","is-referenced-by-count":0,"title":["A 20-minute, free-running, whole-heart cardiac MRI to image myocardial injury following reperfused myocardial infarction: demonstration in a large animal model"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-8066","authenticated-orcid":false,"given":"Xinheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology & Imaging Sciences and Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN 46202-1228,","place":["United 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