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It also substantially reduces calcium and stent blooming artifacts. Appropriate patient selection and task-based optimization of acquisition, reconstruction, and interpretation are critical to realize these benefits. Vascular imaging examinations for which early evidence shows that PCD-CT demonstrates higher diagnostic performance compared to conventional CT include coronary CT angiography (CTA) for evaluation of partially calcified plaques or stents, peripheral runoff CTA, detection of cerebrospinal fluid-venous fistulas, and head CTA for evaluation of small intracranial vessels and aneurysms. Current limitations include excessive image noise with the sharpest reconstruction kernels and challenges when adapting conventional CT protocols (eg, requiring sharper kernels, thinner slices, higher matrices, tailored scan modes) to achieve time-efficient image reconstruction and hanging protocols. New solutions and directions will include deep-learning-based image noise reduction, improved spectral separation, strategic triage of specific patient populations to PCD-CT systems, and subspecialty clinical practice recommendations for this new technology.<\/jats:p>","DOI":"10.1093\/radadv\/umag021","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:27:36Z","timestamp":1776166056000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical benefits and current challenges of photon-counting detector CT in vascular imaging"],"prefix":"10.1093","volume":"3","author":[{"given":"Ahmed O","family":"El Sadaney","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN, 55902,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix E","family":"Diehn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN, 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