{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:08:17Z","timestamp":1792786097119,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DC022228"],"award-info":[{"award-number":["R01DC022228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health"},{"name":"Mayo Clinic CT Clinical Innovation Center","id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Mayo Clinic Graduate School of Biomedical Sciences","id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evaluation of middle ear prostheses requires high-resolution imaging to assess position and structural integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the diagnostic performance of photon-counting-detector (PCD)-CT for middle ear prosthesis imaging in cadaveric specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Nine different middle ear prostheses were implanted in 5 fresh-frozen whole-head specimens, both in correct anatomic position and displaced to mimic malposition. Specimens were scanned on PCD-CT (NAEOTOM Alpha, Siemens) and energy-integrating-detector (EID)-CT (SOMATOM Force, Siemens), reconstructed at 0.2\u2009mm and 0.4\u2009mm, respectively. Eighteen cases (9 prostheses, 2 positions) per scanner were evaluated by 2 neuroradiologists (36 readings), blinded to scanner and position, who scored prosthesis position, reader confidence, and overall image quality. Agreement with the reference standard and between readers was compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PCD-CT showed higher diagnostic confidence compared with EID-CT, while accuracy and inter-reader agreement did not demonstrate significant differences between scanners. Correct readings, PCD-CT versus EID-CT: lateral contact, 31\/36 (86.1%; 95% CI, 58.3-94.4) vs 29\/36 (80.6%; 95% CI, 55.6-91.7), P\u2009=\u2009.500; medial contact, 30\/36 (83.3%; 95% CI, 55.6-94.4) vs 26\/36 (72.2%; 95% CI, 50.0-83.3), P\u2009=\u2009.250. PCD-CT identified all cases of complete contact loss (score 3), while EID-CT missed 1 reading per contact. Inter-reader agreement may be higher with PCD-CT vs EID-CT (lateral: \u03baw: 0.804 [95% CI, 0.578-0.941] vs 0.571 [95% CI, 0.302-0.778], P\u2009=\u2009.250; medial: 0.684 [95% CI, 0.191-0.934] vs 0.481 [95% CI, 0.024-0.835], P\u2009=\u2009.250). Reader confidence was significantly higher with PCD-CT; mean paired differences for Readers 1 and 2 were 9.4 (95% CI, 1.8-17.1; Holm-adjusted P\u2009=\u2009.019) and 23.1 points (95% CI, 13.4-32.7; P\u2009&amp;lt;\u2009.001) for lateral contact, and 16.4 (95% CI, 10.0-22.8; P\u2009&amp;lt;\u2009.001) and 17.8 points (95% CI, 6.8-28.8; P\u2009=\u2009.007) for medial contact. Readers preferred PCD-CT image quality in 16\/18 (88.9%; 95% CI, 65.3-98.6) and 17\/18 cases (94.4%; 95% CI, 72.7-99.9), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PCD-CT was associated with significantly higher reader confidence and preferred image quality, without significant differences in diagnostic accuracy or inter-reader agreement. These findings suggest that PCD-CT is a promising modality for postoperative middle ear evaluations and warrants further investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/radadv\/umag041","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:21:44Z","timestamp":1789384904000},"source":"Crossref","is-referenced-by-count":0,"title":["Improved visualization of malpositioned middle ear prostheses using photon-counting detector CT: a cadaver study"],"prefix":"10.1093","volume":"3","author":[{"given":"Maryam","family":"Sadeghian","sequence":"first","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]},{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Farnsworth","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John I","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J","family":"Treb","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl R","family":"Khandalavala","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E","family":"Babajanian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Bruesewitz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R","family":"Swicklik","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-8735","authenticated-orcid":false,"given":"Fang-Shu","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-332X","authenticated-orcid":false,"given":"Cynthia H","family":"McCollough","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]},{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-9481","authenticated-orcid":false,"given":"Shuai","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905,","place":["United States"]},{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"9","key":"2026100321164198500_umag041-B1","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.medengphy.2012.02.011","article-title":"Model-oriented review and multi-body simulation of the ossicular chain of the human middle ear","volume":"34","author":"Volandri","year":"2012","journal-title":"Med Eng Phys"},{"issue":"5","key":"2026100321164198500_umag041-B2","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.21037\/qims-23-1600","article-title":"Application of convolutional neural networks in medical images: a bibliometric analysis","volume":"14","author":"Jia","year":"2024","journal-title":"Quant Imaging Med Surg"},{"issue":"1","key":"2026100321164198500_umag041-B3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/ohn.974","article-title":"Indications, surgical strategies and hearing outcomes of revision stapes surgery for otosclerosis: a systematic review and meta-analysis on 2602 patients","volume":"172","author":"Tomasoni","year":"2025","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"Suppl 1","key":"2026100321164198500_umag041-B4","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.14639\/0392-100X-suppl.1_3-45-2025-A1339","article-title":"Stapes revision surgery: intraoperative findings and audiological results. A multicentric study","volume":"45","author":"Bruschini","year":"2025","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"10","key":"2026100321164198500_umag041-B5","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3390\/brainsci13101476","article-title":"Extrusion and dislocation in titanium middle ear prostheses: a literature review","volume":"13","author":"Canzi","year":"2023","journal-title":"Brain Sci"},{"issue":"2","key":"2026100321164198500_umag041-B6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0720-048x(01)00379-5","article-title":"CT and MR imaging after middle ear surgery","volume":"40","author":"Kosling","year":"2001","journal-title":"Eur J Radiol"},{"issue":"3","key":"2026100321164198500_umag041-B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ajme.2017.07.001","article-title":"Otosclerosis and complications of stapedectomy: CT and MRI correlation","volume":"54","author":"Ali","year":"2019","journal-title":"Alexandria J Med"},{"issue":"3","key":"2026100321164198500_umag041-B8","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1148\/rg.2021200126","article-title":"Postoperative imaging of the temporal bone","volume":"41","author":"Tames","year":"2021","journal-title":"Radiographics"},{"issue":"3","key":"2026100321164198500_umag041-B9","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1148\/radiographics.20.3.g00ma03593","article-title":"CT evaluation of prosthetic ossicular reconstruction procedures: what the otologist needs to know","volume":"20","author":"Stone","year":"2000","journal-title":"Radiographics"},{"issue":"873","key":"2026100321164198500_umag041-B10","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1259\/bjr.73.873.11064662","article-title":"Vertigo after stapes surgery: the role of high resolution CT","volume":"73","author":"Pickuth","year":"2000","journal-title":"Br J Radiol"},{"issue":"2","key":"2026100321164198500_umag041-B11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/RLI.0000000000000614","article-title":"Dose reduction for sinus and temporal bone imaging using photon-counting detector CT with an additional tin filter","volume":"55","author":"Rajendran","year":"2020","journal-title":"Invest Radiol"},{"issue":"1147","key":"2026100321164198500_umag041-B12","doi-asserted-by":"publisher","first-page":"20220544","DOI":"10.1259\/bjr.20220544","article-title":"Photon-counting detector CT: early clinical experience review","volume":"96","author":"Sartoretti","year":"2023","journal-title":"Br J Radiol"},{"issue":"1","key":"2026100321164198500_umag041-B13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1148\/radiol.212579","article-title":"First clinical photon-counting detector CT system: technical evaluation","volume":"303","author":"Rajendran","year":"2022","journal-title":"Radiology"},{"issue":"3","key":"2026100321164198500_umag041-B14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1148\/rg.2019180115","article-title":"Photon-counting detector CT: system design and clinical applications of an emerging technology","volume":"39","author":"Leng","year":"2019","journal-title":"Radiographics"},{"issue":"3","key":"2026100321164198500_umag041-B15","doi-asserted-by":"publisher","first-page":"e230853","DOI":"10.1148\/radiol.230853","article-title":"Comparison of photon-counting detector and energy-integrating detector CT for visual estimation of coronary percent luminal stenosis","volume":"309","author":"McCollough","year":"2023","journal-title":"Radiology"},{"issue":"2","key":"2026100321164198500_umag041-B16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/RCT.0000000000001554","article-title":"Photon-counting detector computed tomography versus energy-integrating detector computed tomography for coronary artery calcium quantitation","volume":"48","author":"McCollough","year":"2024","journal-title":"J Comput Assist Tomogr"},{"issue":"11","key":"2026100321164198500_umag041-B17","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/RLI.0000000000000488","article-title":"150-Mum spatial resolution using photon-counting detector computed tomography technology: technical performance and first patient images","volume":"53","author":"Leng","year":"2018","journal-title":"Invest Radiol"},{"issue":"1","key":"2026100321164198500_umag041-B18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1148\/radiol.213203","article-title":"Counting photons: the next era for CT imaging?","volume":"303","author":"Willemink","year":"2022","journal-title":"Radiology"},{"issue":"1","key":"2026100321164198500_umag041-B19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13244-023-01467-w","article-title":"Photon-counting CT allows better visualization of temporal bone structures in comparison with current generation multi-detector CT","volume":"14","author":"Hermans","year":"2023","journal-title":"Insights Imaging"},{"issue":"4","key":"2026100321164198500_umag041-B20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3174\/ajnr.A7452","article-title":"A new frontier in temporal bone imaging: photon-counting detector CT demonstrates superior visualization of critical anatomic structures at reduced radiation dose","volume":"43","author":"Benson","year":"2022","journal-title":"AJNR Am J Neuroradiol"},{"issue":"9","key":"2026100321164198500_umag041-B21","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3174\/ajnr.A5768","article-title":"Comparison of a photon-counting-detector CT with an energy-integrating-detector CT for temporal bone imaging: a cadaveric study","volume":"39","author":"Zhou","year":"2018","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"2026100321164198500_umag041-B22","doi-asserted-by":"publisher","first-page":"e1205","DOI":"10.1097\/MAO.0000000000003682","article-title":"Photon-counting detector CT for temporal bone imaging: up to three times the resolution at half the radiation dose","volume":"43","author":"Macielak","year":"2022","journal-title":"Otol Neurotol"},{"issue":"7","key":"2026100321164198500_umag041-B23","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1097\/RLI.0000000000000980","article-title":"Technical basics and clinical benefits of photon-counting CT","volume":"58","author":"Flohr","year":"2023","journal-title":"Invest Radiol"},{"issue":"8","key":"2026100321164198500_umag041-B24","doi-asserted-by":"publisher","first-page":"5309","DOI":"10.1007\/s00330-023-09596-y","article-title":"Clinical applications of photon counting detector CT","volume":"33","author":"McCollough","year":"2023","journal-title":"Eur Radiol"},{"issue":"4","key":"2026100321164198500_umag041-B25","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.3174\/ajnr.A9075","article-title":"Comparative analysis of middle ear prostheses using photon-counting detector CT versus conventional CT","volume":"47","author":"Dutta","year":"2026","journal-title":"AJNR Am J Neuroradiol"},{"issue":"5","key":"2026100321164198500_umag041-B26","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.3174\/ajnr.A9103","article-title":"Impact of spatial resolution on CT imaging of middle ear prostheses: comparison of photon-counting and energy-integrating detectors","volume":"47","author":"Sadeghian","year":"2026","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"2026100321164198500_umag041-B27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"issue":"8","key":"2026100321164198500_umag041-B28","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.1007\/s00330-023-09545-9","article-title":"The technical development of photon-counting detector CT","volume":"33","author":"McCollough","year":"2023","journal-title":"Eur Radiol"},{"issue":"4","key":"2026100321164198500_umag041-B29","doi-asserted-by":"publisher","first-page":"043504","DOI":"10.1117\/1.JMI.3.4.043504","article-title":"Dose-efficient ultrahigh-resolution scan mode using a photon counting detector computed tomography system","volume":"3","author":"Leng","year":"2016","journal-title":"J Med Imaging (Bellingham)"},{"key":"2026100321164198500_umag041-B30","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejmp.2020.10.030","article-title":"Photon-counting CT review","volume":"79","author":"Flohr","year":"2020","journal-title":"Phys Med"},{"issue":"5","key":"2026100321164198500_umag041-B31","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3174\/ajnr.A8410","article-title":"Comprehensive review of inner ear anatomy on photon-counting CT","volume":"46","author":"Rao","year":"2025","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"2026100321164198500_umag041-B32","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1177\/01945998211062074","article-title":"Revision stapes surgery: hearing symptoms and associations with intraoperative findings and outcomes","volume":"167","author":"Luryi","year":"2022","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Radiology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/radadv\/advance-article-pdf\/doi\/10.1093\/radadv\/umag041\/71103847\/umag041.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/radadv\/article-pdf\/3\/5\/umag041\/71103847\/umag041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/radadv\/article-pdf\/3\/5\/umag041\/71103847\/umag041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:16:47Z","timestamp":1791076607000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/radadv\/article\/doi\/10.1093\/radadv\/umag041\/8799007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/radadv\/umag041","relation":{},"ISSN":["2976-9337"],"issn-type":[{"value":"2976-9337","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,9]]},"article-number":"umag041"}}