{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:17:03Z","timestamp":1753877823515,"version":"3.41.2"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":192,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute for Health Research (NIHR) Leeds and Oxford Biomedical Research Centre (BRC), UK"},{"name":"NHMRC, C.\u00a0J. Martin, Research Fellow & Lecturer, School of Health Sciences, University of South Australia, Adelaide"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriatic disease (PsD) is a complex systemic disorder with cutaneous and musculoskeletal manifestations. Current evidence on pharmacological interventions, effective across the spectrum of clinical manifestations of early, systemic treatment-na\u00efve PsD, is limited. This review aims to appraise such evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review examined seven patient\u2013intervention\u2013comparator\u2013outcome research questions to address the efficacy of the interventions on the following: across the spectrum of clinical manifestations PsD activity; peripheral arthritis; dactylitis; spondylitis; enthesitis; skin; and nails. Early PsD was defined as a disease duration of \u22642\u2009years, except for studies investigating outcomes restricted to the skin. Eligible references were clinical trials or well-designed prospective studies\/series reporting on adult humans, untreated, with cutaneous and\/or musculoskeletal features of PsD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine references (out of 160\u2009319, publication range 1946\u20132019) fulfilled the eligibility criteria. No study adopted comprehensive (that is, simultaneous assessment of different PsD manifestations) composite indices as primary outcome measures. Individual studies reported that apremilast and biologics successfully improved outcomes (disease activity index for PsA, minimal disease activity, PsA DAS, psoriasis area and severity index, PsA response criteria) when efficacy analyses were restricted to single manifestations of untreated PsD. Only qualitative synthesis of evidence was possible, owing to the following factors: data heterogeneity (disease classification criteria, outcome measures); unavailable data subsets (focused on early, untreated PsD) at the single study level; and insufficient data on the exposure of participants to previous treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Effective interventions, albeit limited in scope, were found for early, treatment-na\u00efve PsD. No study provided evidence about the management of co-occurring cutaneous and musculoskeletal manifestations in early, treatment-na\u00efve PsD. This review highlights an unmet need in research on early PsD.<\/jats:p><\/jats:sec>","DOI":"10.1093\/rap\/rkaa032","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T15:54:32Z","timestamp":1594482872000},"source":"Crossref","is-referenced-by-count":4,"title":["Systematic literature review of non-topical treatments for early, untreated (systemic therapy na\u00efve) psoriatic disease: a GRAPPA initiative"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-161X","authenticated-orcid":false,"given":"Gabriele","family":"De Marco","sequence":"first","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-8812","authenticated-orcid":false,"given":"Anna","family":"Berekm\u00e9ri","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-663X","authenticated-orcid":false,"given":"Laura C","family":"Coates","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-7122","authenticated-orcid":false,"given":"Sayam","family":"Dubash","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Emmel","sequence":"additional","affiliation":[{"name":"Library & Information Service, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-0592","authenticated-orcid":false,"given":"Dafna D","family":"Gladman","sequence":"additional","affiliation":[{"name":"University of Toronto, Toronto Western Hospital and Krembil Research Institute, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-5328","authenticated-orcid":false,"given":"Ennio","family":"Lubrano","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Scienze della Salute \u201cVincenzo Tiberio\u201d, Universit\u00e0 degli Studi del Molise, Campobasso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-8226","authenticated-orcid":false,"given":"Dennis G","family":"McGonagle","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-3932","authenticated-orcid":false,"given":"Farrouq","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-5902","authenticated-orcid":false,"given":"Antonio","family":"Marchesoni","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, ASST Gaetano Pini-CTO, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-1879","authenticated-orcid":false,"given":"Laura","family":"Mason","sequence":"additional","affiliation":[{"name":"Library & Information Service, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-0775","authenticated-orcid":false,"given":"Alexis","family":"Ogdie","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-4926","authenticated-orcid":false,"given":"Miriam","family":"Wittmann","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-9105","authenticated-orcid":false,"given":"Philip S","family":"Helliwell","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-3407","authenticated-orcid":false,"given":"Helena","family":"Marzo-Ortega","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"2021013016260945400_rkaa032-B1","first-page":"210","article-title":"Psoriasis, psoriatic arthritis, or psoriatic disease?","volume":"33","author":"Scarpa","year":"2006","journal-title":"J Rheumatol"},{"key":"2021013016260945400_rkaa032-B2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1468-3083.2010.03574.x","article-title":"Psoriatic disease: concepts and implications","volume":"24","author":"Scarpa","year":"2010","journal-title":"J Eur Acad Dermatol"},{"key":"2021013016260945400_rkaa032-B3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/rheumatology\/30.5.339","article-title":"A re-evaluation of the osteoarticular manifestations of psoriasis","volume":"30","author":"Helliwell","year":"1991","journal-title":"Br J Rheumatol"},{"key":"2021013016260945400_rkaa032-B4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1365-2133.2007.08148.x","article-title":"Psoriasis and psoriatic arthritis: separate or one and the same?","volume":"157","author":"Ciocon","year":"2007","journal-title":"Br J Dermatol"},{"key":"2021013016260945400_rkaa032-B5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ncprheum0670","article-title":"Psoriatic disease\u2014from skin to bone","volume":"3","author":"Ritchlin","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"key":"2021013016260945400_rkaa032-B6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.autrev.2018.11.007","article-title":"Amplifying the concept of psoriatic arthritis: the role of autoimmunity in systemic psoriatic disease","volume":"18","author":"Chimenti","year":"2019","journal-title":"Autoimmun Rev"},{"key":"2021013016260945400_rkaa032-B7","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2021013016260945400_rkaa032-B8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","article-title":"Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition","volume":"15","author":"Scher","year":"2019","journal-title":"Nat Rev Rheumatol"},{"year":"2016","author":"Michalek","key":"2021013016260945400_rkaa032-B9"},{"key":"2021013016260945400_rkaa032-B10","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1111\/jdv.13150","article-title":"Physician perspectives in the management of psoriasis and psoriatic arthritis: results from the population-based multinational assessment of psoriasis and psoriatic arthritis survey","volume":"29","author":"van de Kerkhof","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2021013016260945400_rkaa032-B11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jaad.2018.11.057","article-title":"Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics","volume":"80","author":"Menter","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2021013016260945400_rkaa032-B12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s40265-014-0191-y","article-title":"Managing patients with psoriatic disease: the diagnosis and pharmacologic treatment of psoriatic arthritis in patients with psoriasis","volume":"74","author":"Mease","year":"2014","journal-title":"Drugs"},{"key":"2021013016260945400_rkaa032-B13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/art.39573","article-title":"Group for research and assessment of psoriasis and psoriatic arthritis 2015 treatment recommendations for psoriatic arthritis","volume":"68","author":"Coates","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2021013016260945400_rkaa032-B14","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s10067-018-4090-6","article-title":"Psoriatic disease treatment nowadays: unmet needs among the \u201cjungle of biologic drugs and small molecules\u201d","volume":"37","author":"Megna","year":"2018","journal-title":"Clin Rheumatol"},{"key":"2021013016260945400_rkaa032-B15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/annrheumdis-2015-208337","article-title":"European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update","volume":"75","author":"Gossec","year":"2016","journal-title":"Ann Rheum Dis"},{"year":"2019","author":"Group for Research and Assessment of Psoriasis and Psoriatic Arthritis","key":"2021013016260945400_rkaa032-B16"},{"year":"2019","author":"Methodological Expectations of Cochrane Intervention Reviews (MECIR) Manual","key":"2021013016260945400_rkaa032-B17"},{"year":"2019","author":"De Marco","key":"2021013016260945400_rkaa032-B18"},{"key":"2021013016260945400_rkaa032-B19","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"year":"2019","author":"Covidence Systematic Review Software","key":"2021013016260945400_rkaa032-B20"},{"key":"2021013016260945400_rkaa032-B21","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/bjd.18384","article-title":"A 24-week multicentre, randomised, open-label, parallel-group study comparing the efficacy and safety of ixekizumab to fumaric acid esters and methotrexate in patients with moderate-to-severe plaque psoriasis naive to systemic treatment","volume":"182","author":"Reich","year":"2020","journal-title":"Br J Dermatol"},{"key":"2021013016260945400_rkaa032-B22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10067-007-0787-7","article-title":"The effectiveness of a traditional therapeutical approach in early psoriatic arthritis: results of a pilot randomised 6-month trial with methotrexate","volume":"27","author":"Scarpa","year":"2008","journal-title":"Clin Rheumatol"},{"key":"2021013016260945400_rkaa032-B23","first-page":"1024","article-title":"Secukinumab is superior to fumaric acid esters in treating patients with moderate-to-severe plaque psoriasis who are naive to systemic treatments: results from the randomized controlled PRIME trial","author":"Sticherling","year":"2017"},{"key":"2021013016260945400_rkaa032-B24","first-page":"801","article-title":"Efficacy and safety of apremilast in patients with moderate plaque psoriasis with lower BSA: week\u00a016 results from the UNVEIL study","volume":"16","author":"Strober","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"2021013016260945400_rkaa032-B25","first-page":"10","article-title":"Attainment of remission and minimal disease activity after starting methotrexate subcutaneous therapy","volume":"98(Suppl 219","author":"Loginova","year":"2018","journal-title":"Acta Derm Venereol"},{"year":"2016","author":"NCT","key":"2021013016260945400_rkaa032-B26"},{"year":"2017","key":"2021013016260945400_rkaa032-B27"},{"year":"2018","author":"Euctr","key":"2021013016260945400_rkaa032-B28"},{"key":"2021013016260945400_rkaa032-B29","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1111\/jdv.14979","article-title":"Secukinumab treatment in new-onset psoriasis: aiming to understand the potential for disease modification \u2013 rationale and design of the randomized, multicenter STEPIn study","volume":"32","author":"Iversen","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2021013016260945400_rkaa032-B353","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/annrheumdis-2011-200350","article-title":"European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies","volume":"71","author":"Gossec","year":"2012","journal-title":"Ann Rheum Dis"},{"year":"2019","author":"Latin American and Caribbean Health Sciences Literature (LILACS)","key":"2021013016260945400_rkaa032-B34"},{"author":"Moher D, Liberati A, Tetzlaff J, Altman DG, Grp P. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Plos Med 2009;6(7).","key":"2021013016260945400_rkaa032-B35"},{"key":"2021013016260945400_rkaa032-B31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0049-0172(73)90035-8","article-title":"Psoriatic arthritis","volume":"3","author":"Moll","year":"1973","journal-title":"Semin Arthritis Rheum"},{"key":"2021013016260945400_rkaa032-B32","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: development of new criteria from a large international study","volume":"54","author":"Taylor","year":"2006","journal-title":"Arthritis Rheum"}],"container-title":["Rheumatology Advances in Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rheumap\/advance-article-pdf\/doi\/10.1093\/rap\/rkaa032\/33486642\/rkaa032.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/rheumap\/article-pdf\/4\/2\/rkaa032\/36155710\/rkaa032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/rheumap\/article-pdf\/4\/2\/rkaa032\/36155710\/rkaa032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:51:25Z","timestamp":1696391485000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumap\/article\/doi\/10.1093\/rap\/rkaa032\/5870299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/rap\/rkaa032","relation":{},"ISSN":["2514-1775"],"issn-type":[{"type":"electronic","value":"2514-1775"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2020]]},"article-number":"rkaa032"}}