{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:33:46Z","timestamp":1787009626411,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":318,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the relationship between clinical examination\/US synovitis in DMARD-na\u00efve early PsA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible patients underwent matched clinical\/US 44-joint assessment for tender and\/or swollen joints (TJ\/SJ) and US synovitis [grey scale (GS) \u2265 2 or power Doppler (PD) \u2265 1]. Statistical agreement between TJ\/SJ, GS \u2265 2 and PD \u2265 1 was calculated by prevalence-adjusted and bias-adjusted \u03ba (PABAK). To derive probabilities of GS \u2265 2\/PD \u2265 1, mixed-effects logistic regression-modelled odds of US synovitis in TJ\/SJ were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 155 patients, 5616 joints underwent clinical\/US examination. Of these joints, 1039 of 5616 (18.5%) were tender, 550 of 5616 (9.8%) were swollen, 1144 of 5616 (20.4%) had GS \u2265 2, and 292 of 5616 (5.2%) had PD \u2265 1. GS \u2265 2 was most prevalent in concomitantly tender and swollen joints [205 of 462 (44%)], followed by swollen non-tender joints [32 of 88 (36.4%)], tender non-swollen joints [148 of 577 (25.7%)] and non-tender non-swollen joints (subclinical synovitis) [759 of 4489 (16.9%)]. Agreement between SJ\/PD \u2265 1 was high at the individual joint level (82.6\u201396.3%, PABAK 0.65\u20130.93) and for total joints combined (89.9%, PABAK 0.80). SJ\/GS \u2265 2 agreement was greater than between TJ\/GS \u2265 2 [73.5\u201392.6% vs 51.0\u201387.4% (PABAK 0.47\u20130.85 vs PABAK 0.35\u20130.75), respectively]. Swelling was independently associated with higher odds of GS \u2265 2 [odds ratio (OR) (95% CI); 4.37 (2.62, 7.29); P &amp;lt; 0.001] but not tenderness [OR = 1.33 (0.87, 2.06); P = 0.192]. Swelling [OR = 8.78 (3.92, 19.66); P &amp;lt; 0.001] or tenderness [OR = 3.38 (1.53, 7.50); P = 0.003] was independently associated with higher odds of PD \u2265 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Synovitis (GS \u2265 2 and\/or PD \u2265 1) was more likely in swollen joints than in tender joints in DMARD-na\u00efve, early PsA. Agreement indicated that swollen joints were the better proxy for synovitis, adding to greater understanding between clinical and US assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/rap\/rkab086","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T23:19:03Z","timestamp":1637191143000},"source":"Crossref","is-referenced-by-count":13,"title":["Ultrasound shows swollen joints are the better proxy for synovitis than tender joints in DMARD-na\u00efve early psoriatic arthritis"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-7122","authenticated-orcid":false,"given":"Sayam R","family":"Dubash","sequence":"first","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oras 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Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-161X","authenticated-orcid":false,"given":"Gabriele","family":"De Marco","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Merashli","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, American University Hospital, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Wakefield","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal 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