{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:56:29Z","timestamp":1770969389348,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Gastric involvement in patients with early systemic sclerosis (SSc) has not been previously investigated. We aim to evaluate the association of gastric dysrhythmias with gastrointestinal (GI) symptoms and nailfold video capillaroscopy (NVC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional study. Patients with early SSc, completed the UCLA GIT 2.0 questionnaire, performed an NVC, and a surface Electrogastrography (EGG). Descriptive statistics was used for demographic and clinical characteristics and Fisher and Kendall Tau tests were used for association analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>75 patients were screened, 30 patients were consecutively enrolled, 29 performed the EGG and 1 patient had a non-interpretable NVC. 29\/30 were female with a mean age of 48.7\u2009years (25\u201372). The mean disease duration from the first non-RP symptom was 22.6 +\/-10.8\u2009months and most of the patients had limited disease (76.6%). Total GIT 2.0 score symptoms were moderate-severe in 63% of the participants and 28\/29 had an abnormal EGG. Bradygastria was the most common pattern present in 70% of the participants. NVC patterns: 17% early, 34% active, 28% scleroderma-like, 14% non-specific, and 2 patients had a normal NVC. There was no association between severe GI symptoms or NVC patterns and severely abnormal EGG, but the presence of bradygastria was associated with severe impairment in the social functioning area (p 0.018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Gastric dysmotility is common in early SSc and there is a lack of correlation between GI symptoms and NVC scleroderma patterns. EGG is a sensitive, cheap, and non-invasive exam, that may be an alternative to early diagnosis of GI involvement.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/rap\/rkae041","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T20:59:45Z","timestamp":1710277185000},"source":"Crossref","is-referenced-by-count":1,"title":["Gastric dysrhythmias in patients with early systemic sclerosis: a cross-sectional study"],"prefix":"10.1093","volume":"8","author":[{"given":"Daniela","family":"Seelmann","sequence":"first","affiliation":[{"name":"Rheumatology Section, Medicine Department, Hospital Cl\u00ednico de la Universidad de Chile , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Paz","family":"Poblete","sequence":"additional","affiliation":[{"name":"Rheumatology Section, Medicine Department, Hospital Cl\u00ednico de la Universidad de Chile , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Rheumatology Section, Medicine Department, Hospital Cl\u00ednico de la Fuerza A\u00e9rea de Chile , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"Madrid","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Medicine Department, Hospital Cl\u00ednico de la Universidad de Chile , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Muhlenbrock","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Medicine Department, Hospital Cl\u00ednico de la Universidad de Chile , Santiago, Chile"},{"name":"Digestive Disease Center, Internal Medicine Department, Universidad de los Andes , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Estay","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Medicine Department, Hospital Cl\u00ednico de la Universidad de Chile , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-3728","authenticated-orcid":false,"given":"Annelise","family":"Goecke","sequence":"additional","affiliation":[{"name":"Rheumatology Section, Medicine Department, Hospital Cl\u00ednico de la Universidad de Chile , Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"2024040210052368100_rkae041-B1","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3899\/jrheum.201594","article-title":"Systematic analysis of the literature in search of defining systemic sclerosis subsets","volume":"48","author":"Nevskaya","year":"2021","journal-title":"J Rheumatol"},{"key":"2024040210052368100_rkae041-B2","doi-asserted-by":"crossref","first-page":"e0163894","DOI":"10.1371\/journal.pone.0163894","article-title":"Incidences and risk factors of organ manifestations in the early course of systemic sclerosis: a longitudinal EUSTAR study","volume":"11","author":"Jaeger","year":"2016","journal-title":"PLoS One"},{"key":"2024040210052368100_rkae041-B3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s40674-014-0005-0","article-title":"Management of gastrointestinal involvement in scleroderma","volume":"1","author":"Nagaraja","year":"2015","journal-title":"Curr Treatm Opt Rheumatol"},{"key":"2024040210052368100_rkae041-B4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/rheumatology\/key350","article-title":"Severe gastrointestinal disease in very early systemic sclerosis is associated with early mortality","volume":"58","author":"Richard","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"2024040210052368100_rkae041-B5","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3899\/jrheum.110826","article-title":"Effect of gastrointestinal manifestations on quality of life in 87 consecutive patients with systemic sclerosis","volume":"39","author":"Omair","year":"2012","journal-title":"J Rheumatol"},{"key":"2024040210052368100_rkae041-B6","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/1529-0131(200011)43:11<2437::AID-ANR10>3.0.CO;2-U","article-title":"Severe organ involvement in systemic sclerosis with diffuse scleroderma","volume":"43","author":"Steen","year":"2000","journal-title":"Arthritis Rheum"},{"key":"2024040210052368100_rkae041-B7","first-page":"1330","article-title":"Association of autonomic nervous dysfunction and esophageal dysmotility in systemic sclerosis","volume":"25","author":"Lock","year":"1998","journal-title":"J Rheumatol"},{"key":"2024040210052368100_rkae041-B8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0002-9343(69)90044-8","article-title":"Pathologic observations in systemic sclerosis (scleroderma). 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