{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:54:05Z","timestamp":1775091245072,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":155,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32\u2009AR0555885"],"award-info":[{"award-number":["T32\u2009AR0555885"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32\u2009AR007530"],"award-info":[{"award-number":["T32\u2009AR007530"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Recently, a genome-wide association study identified an association between RA-associated interstitial lung disease (ILD) and RPA3-UMAD1 rs12702634 in the Japanese population, especially for patients with a usual interstitial pneumonia (UIP) pattern. We aimed to replicate this association in a European population and test for interaction with MUC5B rs35705950.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this genetic case\u2013control association study, patients with RA and ILD and controls with RA and no ILD were included from France, the USA and the Netherlands. Only cases and controls from European genetic ancestries determined by principal components analysis were included in the analyses. RA was defined by the 1987 ACR or 2010 ACR\/EULAR criteria and ILD by chest high-resolution CT scan, except in the control dataset from the Netherlands, where the absence of ILD was determined by chart review. Patients were genotyped for RPA3-UMAD1 rs12702634 and MUC5B rs35705950. Associations were tested using logistic regression adjusted for sex, age at RA onset, age at ILD onset or at certified absence of ILD, tobacco smoking status and country of origin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 883 patients included, 322 were RA-ILD cases (36.5%). MUC5B rs35705950 was strongly associated with RA-ILD in all datasets {combined adjusted odds ratio [OR] 2.9 [95% CI 2.1, 3.9], P\u2009=\u20091.1\u2009\u00d7\u200910\u221211. No association between RPA3-UMAD1 rs12702634 and RA-ILD was observed [combined OR 1.2 (95% CI 0.8, 1.6), P\u2009=\u20090.31. No interaction was found between RPA3-UMAD1 rs12702634 and MUC5B rs35705950 (P\u2009=\u20090.70).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings did not support a contribution of RPA3-UMAD1 rs12702634 to the overall RA-ILD susceptibility in the European population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/rap\/rkae059","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T01:23:01Z","timestamp":1717550581000},"source":"Crossref","is-referenced-by-count":4,"title":["<i>RPA3-UMAD1<\/i> rs12702634 and rheumatoid arthritis\u2013associated interstitial lung disease in European ancestry"],"prefix":"10.1093","volume":"8","author":[{"given":"Pierre-Antoine","family":"Juge","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR 1152 , Paris, France"},{"name":"Service de Rhumatologie, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-4618","authenticated-orcid":false,"given":"Jeffrey A","family":"Sparks","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Gazal","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA"},{"name":"Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Ebstein","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-0024","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Borie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR 1152 , Paris, France"},{"name":"Service de Pneumologie, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre","family":"Debray","sequence":"additional","affiliation":[{"name":"Service de Radiologie, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Kannengiesser","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR 1152 , Paris, France"},{"name":"Service de G\u00e9n\u00e9tique, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory C","family":"McDermott","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy J","family":"Doyle","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA, USA"},{"name":"Division of Pulmonary and Critical Care, Brigham and Women's Hospital , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coline H M","family":"van Moorsel","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands"},{"name":"Division of Heart and Lungs, University Medical Center Utrecht , Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne J","family":"van der Vis","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands"},{"name":"Division of Heart and Lungs, University Medical Center Utrecht , Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan C","family":"Grutters","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands"},{"name":"Division of Heart and Lungs, University Medical Center Utrecht , Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Knevel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center , Leiden, The Netherlands"},{"name":"Translational & Clinical Research Institute, Newcastle University , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-905X","authenticated-orcid":false,"given":"Sascha L","family":"Heckert","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center , Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Vasarmidi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Pneumonology, Department of Respiratory Medicine, School of Medicine, University of Crete , Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina M","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Pneumonology, Department of Respiratory Medicine, School of Medicine, University of Crete , Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette H M","family":"van der Helm van Mil","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center , Leiden, The Netherlands"},{"name":"Department of Rheumatology, Erasmus MC , Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-7539","authenticated-orcid":false,"given":"Catherine","family":"Boileau","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR 1152 , Paris, France"},{"name":"Service de Pneumologie, H\u00f4pital Bichat-Claude Bernard, AP-HP , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-0307","authenticated-orcid":false,"given":"Philippe","family":"Dieud\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM UMR 1152 , Paris, France"},{"name":"Service de Rhumatologie, H\u00f4pital Bichat-Claude Bernard, AP-HP , 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