{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:02:16Z","timestamp":1784649736304,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to investigate serum levels of B cell activation factor (BAFF) and chemokine C-X-C ligand 13 (CXCL13) in SSc patients with\/without lung involvement and correlation with clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples were collected from four groups: SSc patients with progressive\/in remission\/without lung involvement (n\u2009=\u200921 for each group) and healthy controls (n\u2009=\u200932). Progressive interstitial lung disease (ILD) was defined based on the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society and Asociaci\u00f3n Latinoamericana de T\u00f3rax (ATS\/ERS\/JRS\/ALAT) guidelines. ELISAs were used to measure BAFF and CXCL13 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results revealed significantly elevated serum CXCL13 levels in SSc patients with progressive lung involvement compared with other SSc groups and healthy controls (311\u2009ng\/ml vs 273, 282 and 231\u2009ng\/ml; P\u2009=\u20090.013). Moreover, a positive correlation was observed between modified Rodnan skin score (MRSS), pulmonary artery pressure (PAP) and CXCL13 levels (P\u2009=\u20090.029 for PAP, P\u2009=\u20090.001 for MRSS). Serum BAFF and CXCL13 were independently associated with MRSS, PAP and European League Against Rheumatism Scleroderma Trials and Research group disease activity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that increased serum CXCL13 levels are associated with progressive pulmonary involvement in SSc patients. Serum BAFF levels were also related to SSc but not associated with ILD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/rap\/rkaf001","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:30:38Z","timestamp":1737095438000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum CXCL-13 levels in patients with progressive systemic sclerosis are associated with the severity of interstitial lung disease"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-7725","authenticated-orcid":false,"given":"Derya","family":"Yildirim","sequence":"first","affiliation":[{"name":"Rheumatology Clinic, Sincan Education and Research Hospital , Ankara,","place":["Turkey"]},{"name":"Department of Rheumatology, Gazi University Faculty of Medicine , 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