{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:01:05Z","timestamp":1790816465495,"version":"4.1.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Hypermobility spectrum disorders (HSD) and hypermobile Ehlers\u2013Danlos syndrome (h-EDS) are connective tissue disorders associated with joint hypermobility, pain, fatigue and autonomic dysfunction. We sought to assess sexual function in women with h-EDS\/HSD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this cross-sectional community-based case\u2013control study, women with h-EDS\/HSD completed the following online questionnaires: Female Sexual Function Index (FSFI), 31-item Composite Autonomic Symptom Score (COMPASS-31), Beck Depression Inventory-II (BDI-II) and an additional short form with questions pertaining to comorbidities and sexual activity. Scores were compared with those of healthy female controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 84 women with h-EDS\/HSD [mean age 37.1\u2009years (s.d. 8.4)] and 75 healthy women [mean age 29.79\u2009years (s.d. 5.38)] completed the questionnaires. Of these, 75% were diagnosed with h-EDS, 25% with HSD and 58% had concurrent postural orthostatic tachycardia syndrome. A majority of women with h-EDS\/HSD (52%) did not engage in any sexual activity, and only 25% reported having sexual intercourse with a partner in the past 6\u2009months. The mean COMPASS-31 score was 51.5 (s.d. 13.8), mean BDI-II score was 24.6 (s.d. 11.4) and mean FSFI score was 15.3 (s.d. 7.9) in the patient group. Compared with healthy controls, women with h-EDS\/HSD had decreased FSFI scores in the subdomains of desire, arousal, lubrication, orgasm and sexual satisfaction. Neither BDI-II nor COMPASS-31 scores were predictive of the FSFI score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with healthy women, we found significant sexual dysfunction in women with h-EDS\/HSD, which did not correlate with depressive or autonomic symptoms in this cohort. Given its health implications, sexual dysfunction represents a significant unmet need that calls for development of targeted diagnostic and therapeutic approaches in the care of women with h-EDS\/HSD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/rap\/rkaf023","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T21:20:03Z","timestamp":1741123203000},"source":"Crossref","is-referenced-by-count":5,"title":["Sexual dysfunction in women with hypermobile Ehlers\u2013Danlos syndrome and hypermobility spectrum disorders: an online community-based study"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9378-6756","authenticated-orcid":false,"given":"Emily","family":"Fuster","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Buffalo Jacobs School of Medicine and Biomedical Sciences , Buffalo, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-2985","authenticated-orcid":false,"given":"Omid","family":"Mirmosayyeb","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Buffalo Jacobs School of Medicine and Biomedical Sciences , Buffalo, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-2031","authenticated-orcid":false,"given":"Svetlana","family":"Blitshteyn","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Buffalo Jacobs School of Medicine and Biomedical Sciences , Buffalo, NY,","place":["USA"]},{"name":"Dysautonomia Clinic , Williamsville, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"2025052701320060500_rkaf023-B1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2478\/rir-2023-0010","article-title":"Hypermobility spectrum disorders: a review","volume":"4","author":"Carroll","year":"2023","journal-title":"Rheumatol Immunol Res"},{"key":"2025052701320060500_rkaf023-B2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ajmg.c.31539","article-title":"A framework for the classification of joint hypermobility and related conditions","volume":"175","author":"Castori","year":"2017","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2025052701320060500_rkaf023-B3","article-title":"What is HSD?","author":"Ehlers\u2013Danlos Society"},{"key":"2025052701320060500_rkaf023-B4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.amjmed.2017.02.013","article-title":"Joint hypermobility syndrome: recognizing a commonly overlooked cause of chronic pain","volume":"130","author":"Kumar","year":"2017","journal-title":"Am J Med"},{"key":"2025052701320060500_rkaf023-B5","first-page":"481","article-title":"Hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders","volume":"103","author":"Yew","year":"2021","journal-title":"Am Fam Physician"},{"key":"2025052701320060500_rkaf023-B6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ajmg.c.31939","article-title":"High rate of dyspareunia and probable vulvodynia in Ehlers-Danlos syndromes and hypermobility spectrum disorders: an online survey","volume":"187","author":"Glayzer","year":"2021","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2025052701320060500_rkaf023-B7","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.mayocp.2012.10.013","article-title":"COMPASS 31, a refined and abbreviated Composite Autonomic Symptom Score","volume":"87","author":"Sletten","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"2025052701320060500_rkaf023-B8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"key":"2025052701320060500_rkaf023-B9","first-page":"44","article-title":"Comparison of sexual dysfunction in women with migraine and multiple sclerosis (MS)","volume":"11","author":"Askari","year":"2016","journal-title":"Maedica (Bucur)"},{"key":"2025052701320060500_rkaf023-B10","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1111\/jsm.12622","article-title":"Correlates of sexual function in male and female patients with multiple sclerosis","volume":"11","author":"Lew-Starowicz","year":"2014","journal-title":"J Sex Med"},{"key":"2025052701320060500_rkaf023-B11","volume-title":"Beck depression inventory\u2014II. Psychological assessment","author":"Beck","year":"1996"},{"key":"2025052701320060500_rkaf023-B12","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.3390\/jcm13082274","article-title":"Sexual dysfunction in postural orthostatic tachycardia syndrome (POTS): a cross-sectional, case-control study","volume":"13","author":"Blitshteyn","year":"2024","journal-title":"J Clin Med"},{"key":"2025052701320060500_rkaf023-B13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/pm\/pnac117","article-title":"Sexual functioning among adults with chronic pain: prevalence and association with pain-related outcomes","volume":"24","author":"Flegge","year":"2023","journal-title":"Pain Med"},{"key":"2025052701320060500_rkaf023-B14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1080\/00926230701866232","article-title":"Sexual dysfunction as related to severity of fatigue in women with CFS","volume":"34","author":"Blazquez","year":"2008","journal-title":"J Sex Marital Ther"}],"container-title":["Rheumatology Advances in Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rheumap\/advance-article-pdf\/doi\/10.1093\/rap\/rkaf023\/62197610\/rkaf023.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rheumap\/article-pdf\/9\/2\/rkaf023\/62197610\/rkaf023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rheumap\/article-pdf\/9\/2\/rkaf023\/62197610\/rkaf023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:32:13Z","timestamp":1748323933000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumap\/article\/doi\/10.1093\/rap\/rkaf023\/8045327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3,14]]}},"URL":"https:\/\/doi.org\/10.1093\/rap\/rkaf023","relation":{},"ISSN":["2514-1775"],"issn-type":[{"value":"2514-1775","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"rkaf023"}}