{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:22:08Z","timestamp":1780471328138,"version":"3.54.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":232,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000291","name":"Kidney Research UK","doi-asserted-by":"publisher","award":["Paed_RP_008_20190926"],"award-info":[{"award-number":["Paed_RP_008_20190926"]}],"id":[{"id":"10.13039\/501100000291","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health Service, NIHR or Department of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this report is to describe a single-centre cohort study and its evolutionary stages into a trial-ready cohort with the vision of stopping kidney failure secondary to IgA vasculitis (IgAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The IgA Vasculitis Study was established as a single-centre, cross-sectional cohort study recruiting children with a clinical diagnosis of IgAV and has evolved into a trial-ready framework. Sociodemographic and clinical data, as well as corresponding biosamples, were collected longitudinally and the natural history of the first 100 recruits is provided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The IgA Vasculitis Study commenced in June 2019. The first 100 children recruited to the study had a mean age of 7.3\u2009years (s.d. 3.7) and a male:female ratio of 1.5:1. At presentation, all children had a lower limb\u2013predominant rash, 76% had musculoskeletal involvement, 43% gastrointestinal involvement and 23% met the definition of nephritis. Most children (54%) were discharged after 6\u2009months, however, 17% required paediatric nephrology input. The mean timing of onset for nephritis was 25.5\u2009days (s.d. 22.9) following disease presentation (range 0.0\u2013101\u2009days). Fourteen children with IgAV nephritis (IgAV-N) received immunosuppression. Children with an older age, residing in more affluent areas, with gastrointestinal involvement or a positive urine dipstick (for proteinuria and\/or haematuria) at presentation had greater odds of developing nephritis. Children with IgAV-N had statistically significantly more hospital visits and unplanned hospital admissions (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nephritis remains a serious consequence of IgAV with little evidence to guide management. This report outlines an exemplar study to advance the field towards better interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/rap\/rkaf099","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T11:55:58Z","timestamp":1755777358000},"source":"Crossref","is-referenced-by-count":1,"title":["The IgA Vasculitis Study: the evolution of a cross-sectional cohort into a trial-ready cohort"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-0255","authenticated-orcid":false,"given":"Chloe E C","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Nephrology, Royal Liverpool and Broadgreen University Hospital Trusts , Liverpool,","place":["UK"]},{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-7915","authenticated-orcid":false,"given":"Julien","family":"Marro","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-6881","authenticated-orcid":false,"given":"Andrew J","family":"Chetwynd","sequence":"additional","affiliation":[{"name":"Centre for Proteome Research, Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5045-9565","authenticated-orcid":false,"given":"Joseph","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-9354","authenticated-orcid":false,"given":"Nikolaos","family":"Skoutelis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Alder Hey Children\u2019s NHS Foundation Trust Hospital , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-441X","authenticated-orcid":false,"given":"Silothabo","family":"Dliso","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research Alder Hey Clinical Research Facility, Clinical Research Division, Alder Hey Children\u2019s NHS Foundation Trust , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-3446","authenticated-orcid":false,"given":"Catherine","family":"McBurney","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research Alder Hey Clinical Research Facility, Clinical Research Division, Alder Hey Children\u2019s NHS Foundation Trust , Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-2390","authenticated-orcid":false,"given":"Louise","family":"Oni","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool,","place":["UK"]},{"name":"Department of Paediatric Nephrology, Great Ormond Street Hospital for Children , London,","place":["UK"]},{"name":"Department of Renal Medicine, UCL Centre for Kidney and Bladder Health, Royal Free Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"2025102620014789600_rkaf099-B1","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1136\/ard.2009.116624","article-title":"EULAR\/PRINTO\/PRES criteria for Henoch-Sch\u00f6nlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. 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