{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T21:47:31Z","timestamp":1780955251812,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the performance, direct costs and radiation exposure of the cancer screening strategy proposed by the International Myositis Assessment and Clinical Studies Group (IMACS) in patients with idiopathic inflammatory myopathies (IIMs) at a myositis referral centre compared with real-world cancer screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective study involving consecutive patients registered in a single-centre prospective IIM database from 2014 to 2024 who had no cancer within 3\u2009years before IIM diagnosis. The patients were stratified into high, moderate or standard risk of cancer according to the IMACS risk stratification model and cancer events were collected within 3\u2009years following IIM diagnosis. Cancer detection rate, direct costs and radiation exposure associated with the IMACS screening strategy were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 183 patients with a median age at IIM onset of 61\u2009years and 66.7% being female. The IMACS risk stratification model classified 75 (41.0%), 100 (54.6%) and 8 (4.4%) patients into high, moderate and standard risk, respectively. We identified 15 (20.0%), 8 (8.0%) and 0 cancer events in each risk group, respectively. The IMACS strategy could have identified 18\/22 (81.8%) of the cancer events. Direct costs and radiation exposure associated with the IMACS strategy were estimated to be higher than our real-world practice, especially in the high- and moderate-risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The IMACS IIM-associated cancer risk stratification model and screening strategy showed satisfactory performance in a single-centre IIM cohort, while most patients would be classified into the high- and moderate-risk groups, where enhanced cancer screening is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/rap\/rkag027","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:41:55Z","timestamp":1771936915000},"source":"Crossref","is-referenced-by-count":1,"title":["Performance and potential impact of the IMACS cancer screening guideline in myositis: analysis in a myositis referral centre"],"prefix":"10.1093","volume":"10","author":[{"given":"Francis Martin","family":"Cuenco","sequence":"first","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo,","place":["Japan"]},{"name":"Department of Internal Medicine, Taytay Doctors Multispecialty Hospital , Taytay,","place":["Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-9116","authenticated-orcid":false,"given":"Shintaro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-1637","authenticated-orcid":false,"given":"Akira","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-1771","authenticated-orcid":false,"given":"Takahisa","family":"Gono","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo,","place":["Japan"]},{"name":"Scleroderma and Myositis Centre of Excellence, Nippon Medical School Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-6136","authenticated-orcid":false,"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo,","place":["Japan"]},{"name":"Scleroderma and Myositis Centre of Excellence, Nippon Medical School Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"2026041222250799300_rkag027-B1","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1056\/NEJMra1402225","article-title":"Inflammatory muscle diseases","volume":"372","author":"Dalakas","year":"2015","journal-title":"N Engl J Med"},{"key":"2026041222250799300_rkag027-B2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3899\/jrheum.140566","article-title":"Polymyositis\/dermatomyositis and malignancy risk: a metaanalysis study","volume":"42","author":"Yang","year":"2015","journal-title":"J Rheumatol"},{"key":"2026041222250799300_rkag027-B3","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/rheumatology\/kew215","article-title":"Temporal relationship between cancer and myositis identifies two distinctive subgroups of cancers: impact on cancer risk and survival in patients with myositis","volume":"55","author":"Kang","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"2026041222250799300_rkag027-B4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/annrheumdis-2017-211402","article-title":"Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study","volume":"77","author":"Dobloug","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2026041222250799300_rkag027-B5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41584-023-01045-w","article-title":"International guideline for idiopathic inflammatory myopathy-associated cancer screening: an international myositis assessment and clinical studies group (IMACS) initiative","volume":"19","author":"Oldroyd","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"2026041222250799300_rkag027-B6","doi-asserted-by":"crossref","first-page":"e15198","DOI":"10.1111\/1756-185X.15198","article-title":"Real-world implications of IMACS malignancy screening guidelines for idiopathic inflammatory myopathies: an evaluation of compliance and economic impact at a tertiary referral center","volume":"27","author":"Teh","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"2026041222250799300_rkag027-B7","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/rheumatology\/keae504","article-title":"Validation of the international myositis assessment and clinical studies group guideline on cancer risk stratification","volume":"64","author":"Tang","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"2026041222250799300_rkag027-B8","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1001\/jamadermatol.2024.3355","article-title":"Application of risk-based cancer screening in patients with dermatomyositis","volume":"160","author":"Stone","year":"2024","journal-title":"JAMA Dermatol"},{"key":"2026041222250799300_rkag027-B9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jaad.2025.03.050","article-title":"International guideline for idiopathic inflammatory myopathy-associated cancer screening recommendations detect most malignancies in patients with dermatomyositis: retrospective performance in a tertiary-care center cohort","volume":"93","author":"Flatley","year":"2025","journal-title":"J Am Acad Dermatol"},{"key":"2026041222250799300_rkag027-B10","doi-asserted-by":"crossref","first-page":"152619","DOI":"10.1016\/j.semarthrit.2024.152619","article-title":"Established and novel insights to guide cancer assessment in patients with idiopathic inflammatory myopathies","volume":"71","author":"Ceribelli","year":"2025","journal-title":"Semin Arthritis Rheum"},{"key":"2026041222250799300_rkag027-B11","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1136\/annrheumdis-2017-211468","article-title":"2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups","volume":"76","author":"Lundberg","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"2026041222250799300_rkag027-B12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nmd.2017.09.016","article-title":"224th ENMC international workshop: clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14\u201316 October 2016","volume":"28","author":"Allenbach","year":"2018","journal-title":"Neuromuscul Disord"},{"key":"2026041222250799300_rkag027-B13","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1378\/chest.10-0180","article-title":"Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?","volume":"138","author":"Connors","year":"2010","journal-title":"Chest"},{"key":"2026041222250799300_rkag027-B14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/mr\/roac056","article-title":"A multianalyte assay for the detection of dermatomyositis-related autoantibodies based on immunoprecipitation combined with immunoblotting","volume":"33","author":"Kuwana","year":"2023","journal-title":"Mod Rheumatol"},{"key":"2026041222250799300_rkag027-B15","doi-asserted-by":"crossref","first-page":"e416","DOI":"10.1097\/MD.0000000000000416","article-title":"Statins and myotoxic effects associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autoantibodies: an observational study in Japan","volume":"94","author":"Watanabe","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"2026041222250799300_rkag027-B16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/14397595.2018.1452179","article-title":"Improved quantification of a commercial enzyme-linked immunosorbent assay kit for measuring anti-MDA5 antibody","volume":"29","author":"Gono","year":"2019","journal-title":"Mod Rheumatol"},{"key":"2026041222250799300_rkag027-B17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1148\/radiol.2481071451","article-title":"Effective doses in radiology and diagnostic nuclear medicine: a catalog","volume":"248","author":"Mettler","year":"2008","journal-title":"Radiology"},{"key":"2026041222250799300_rkag027-B18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1148\/radiol.2323031095","article-title":"Estimated radiation risks potentially associated with full-body CT screening","volume":"232","author":"Brenner","year":"2004","journal-title":"Radiology"},{"key":"2026041222250799300_rkag027-B19","first-page":"1887","article-title":"Robust causal inference using directed acyclic graphs: the R package \u2018dagitty\u2019","volume":"45","author":"Textor","year":"2016","journal-title":"Int J Epidemiol"},{"key":"2026041222250799300_rkag027-B20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/art.33403","article-title":"Myositis-specific anti-155\/140 autoantibodies target transcription intermediary factor 1 family proteins","volume":"64","author":"Fujimoto","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2026041222250799300_rkag027-B21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/rheumatology\/key357","article-title":"The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis","volume":"58","author":"Oldroyd","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"2026041222250799300_rkag027-B22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","article-title":"Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data","volume":"26","author":"Sung","year":"2025","journal-title":"Lancet Oncol"},{"key":"2026041222250799300_rkag027-B23","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob Health"},{"key":"2026041222250799300_rkag027-B24","doi-asserted-by":"crossref","first-page":"100985","DOI":"10.1016\/j.eclinm.2021.100985","article-title":"Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns","volume":"38","author":"Lima","year":"2021","journal-title":"EClinicalMedicine"},{"key":"2026041222250799300_rkag027-B25","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3390\/cancers13081886","article-title":"Prevalence of nasopharyngeal carcinoma in patients with dermatomyositis: a systematic review and meta-analysis","volume":"13","author":"Irekeola","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2026041222250799300_rkag027-B26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/s10165-010-0362-y","article-title":"Incidence and predictive factors for malignancies in 136 Japanese patients with dermatomyositis, polymyositis and clinically amyopathic dermatomyositis","volume":"21","author":"Azuma","year":"2011","journal-title":"Mod Rheumatol"},{"key":"2026041222250799300_rkag027-B27","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00296-019-04428-z","article-title":"Clinical characteristics and prognosis of polymyositis and dermatomyositis associated with malignancy: a 25-year retrospective study","volume":"39","author":"Motomura","year":"2019","journal-title":"Rheumatol Int"},{"key":"2026041222250799300_rkag027-B28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/rheumatology\/kez238","article-title":"Clinical characteristics of cancer-associated myositis complicated by interstitial lung disease: a large-scale multicentre cohort study","volume":"59","author":"Kaneko","year":"2020","journal-title":"Rheumatology (Oxford)"}],"container-title":["Rheumatology Advances in Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rheumap\/advance-article-pdf\/doi\/10.1093\/rap\/rkag027\/67158277\/rkag027.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rheumap\/article-pdf\/10\/2\/rkag027\/67158277\/rkag027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rheumap\/article-pdf\/10\/2\/rkag027\/67158277\/rkag027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:25:30Z","timestamp":1776047130000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumap\/article\/doi\/10.1093\/rap\/rkag027\/8501381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,18]]}},"URL":"https:\/\/doi.org\/10.1093\/rap\/rkag027","relation":{},"ISSN":["2514-1775"],"issn-type":[{"value":"2514-1775","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rkag027"}}