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Here, we developed an oral keratin hydrogel to accelerate the ulcer healing without endoscopic guidance, which can specially adhere to the ulcer because of the high-viscosity gel formation on the wound surface in vivo. Approximately 50% of the ulcer-adhesive keratin hydrogel can resident in ethanol-treated rat stomach within 12\u2009h, while approximately 18% of them maintained in health rat stomach in the same amount of time. Furthermore, Keratin hydrogels accelerated the ethanol-induced gastric ulcer healing by stopping the bleeding, preventing the epithelium cells from gastric acid damage, suppressing inflammation and promoting re-epithelization. The oral administration of keratin hydrogel in gastric ulcer treatment can enhance the patient compliance and reduce the gastroscopy complications. Our research findings reveal a promising biomaterial-based approach for treating gastrointestinal ulcers.<\/jats:p>","DOI":"10.1093\/rb\/rbab008","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T16:03:29Z","timestamp":1615651409000},"source":"Crossref","is-referenced-by-count":38,"title":["Fabrication of ulcer-adhesive oral keratin hydrogel for gastric ulcer healing in a rat"],"prefix":"10.1093","volume":"8","author":[{"given":"Zhongjun","family":"Cheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China"},{"name":"School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China"},{"name":"Bijie Institute of Traditional Chinese Medicine, Bijie City, Guizhou Province 551700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Qing","sequence":"additional","affiliation":[{"name":"Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-3102","authenticated-orcid":false,"given":"Shilei","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, 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