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Peritoneal adhesions are still not effectively treated, and both pharmaceutical therapy and biomaterial barriers have only had modest preventative effects. In this work, we looked into the effectiveness of in-place injectable sodium alginate hydrogel for peritoneal adhesion prevention. The findings demonstrated that sodium alginate hydrogel promoted human peritoneal mesothelial cell proliferation and migration, prevented peritoneal fibrosis by suppressing the production of transforming growth factor-\u03b21, and, most importantly, promoted mesothelium self-repair. These findings imply that this brand-new sodium alginate hydrogel is a good candidate material for peritoneal adhesion prevention.<\/jats:p>","DOI":"10.1093\/rb\/rbad017","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T23:16:52Z","timestamp":1679440612000},"source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of the effectiveness of alginate-based hydrogels in preventing peritoneal adhesions"],"prefix":"10.1093","volume":"10","author":[{"given":"Zhu","family":"Meng","sequence":"first","affiliation":[{"name":"National Institutes for Food and Drug Control , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control , People\u2019s Republic of China"},{"name":"School of Materials Science and Engineering, Beijing Institute of Technology , People\u2019s Republic of 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