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Ideal bone-graft materials remain continuously explored, and bone defect reconstruction remains a significant challenge. Mineralized collagen prepared by bionic mineralization combining organic polymer collagen with inorganic mineral calcium phosphate can effectively imitate the composition and hierarchical structure of natural bone and has good application value in bone repair materials. Magnesium, strontium, zinc and other inorganic components not only can activate relevant signaling pathways to induce differentiation of osteogenic precursor cells but also stimulate other core biological processes of bone tissue growth and play an important role in natural bone growth, and bone repair and reconstruction. This study reviewed the advances in hydroxyapatite\/collagen composite scaffolds and osseointegration with natural bone inorganic components, such as magnesium, strontium and zinc.<\/jats:p>","DOI":"10.1093\/rb\/rbad030","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T18:00:36Z","timestamp":1681840836000},"source":"Crossref","is-referenced-by-count":61,"title":["Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair"],"prefix":"10.1093","volume":"10","author":[{"given":"Wenbo","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University , Shijiazhuang 050051, P.R. China"},{"name":"Key Laboratory of Biomechanics of Hebei Province, Orthopaedic Research Institution of Hebei Province , Shijiazhuang 050051, P.R. 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