{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:23:21Z","timestamp":1785299001253,"version":"3.55.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170046"],"award-info":[{"award-number":["32170046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2022YFH0048"],"award-info":[{"award-number":["2022YFH0048"]}]},{"name":"Technological Innovation and Development Project of Chengdu Bureau of Science and Technology","award":["2021-YF05-01819-SN"],"award-info":[{"award-number":["2021-YF05-01819-SN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dental caries is one of the most prevalent and biofilm-associated oral diseases in humans. Streptococcus mutans, with a high ability to form biofilms by adhering to hard surfaces, has been established as an important etiological agent for dental caries. Therefore, it is crucial to find a way to prevent the formation of cariogenic biofilm. Here, we report an electrospun fibrous membrane that could inhibit the adhesion and biofilm formation of S. mutans. Also, the polystyrene (PS)\/polyvinyl pyrrolidone (PVP) electrospun fibrous membrane altered the 3D biofilm architecture and decreased water-insoluble extracellular polysaccharide production. Notably, the anti-adhesion mechanism which laid in Coulomb repulsion between the negatively charged PS\/PVP electrospun fibrous membrane and S. mutans was detected by zeta potential. Furthermore, metagenomics sequencing analysis and CCK-8 assay indicated that PS\/PVP electrospun fibrous membrane was microbiome-friendly and displayed no influence on the cell viability of human gingival epithelial cells and human oral keratinocytes. Moreover, an in vitro simulation experiment demonstrated that PS\/PVP electrospun fibrous membrane could decrease colony-forming unit counts of S. mutans effectively, and PS\/PVP electrospun fibrous membrane carrying calcium fluoride displayed better anti-adhesion ability than that of PS\/PVP electrospun fibrous membrane alone. Collectively, this research showed that the PS\/PVP electrospun fibrous membrane has potential applications in controlling and preventing dental caries.<\/jats:p>","DOI":"10.1093\/rb\/rbae011","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T03:19:21Z","timestamp":1707535161000},"source":"Crossref","is-referenced-by-count":6,"title":["Microbiome-friendly PS\/PVP electrospun fibrous membrane with antibiofilm properties for dental engineering"],"prefix":"10.1093","volume":"11","author":[{"given":"Jiamin","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuisong","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry, Sichuan University , Chengdu, Sichuan, 610064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-6300","authenticated-orcid":false,"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"2024022717493383300_rbae011-B1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"390","author":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators","year":"2017","journal-title":"Lancet"},{"key":"2024022717493383300_rbae011-B2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0022034513490168","article-title":"Global burden of oral conditions in 1990-2010: a systematic analysis","volume":"92","author":"Marcenes","year":"2013","journal-title":"J Dent 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