{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:14:01Z","timestamp":1792844041100,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Scientific Research and Technological Development Foundation","award":["GuikeAB23026049"],"award-info":[{"award-number":["GuikeAB23026049"]}]},{"DOI":"10.13039\/100012547","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2023GXNSFBA026034"],"award-info":[{"award-number":["2023GXNSFBA026034"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360426"],"award-info":[{"award-number":["82360426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cartilage defects may lead to severe degenerative joint diseases. Tissue engineering based on type I collagen hydrogel that has chondrogenic potential is ideal for cartilage repair. However, the underlying mechanisms of chondrogenic differentiation driven by type I collagen hydrogel have not been fully clarified. Herein, we explored potential collagen receptors and chondrogenic signaling pathways through bioinformatical analysis to investigate the mechanism of collagen-induced chondrogenesis. Results showed that the super enhancer-related genes induced by collagen hydrogel were significantly enriched in the TGF-\u03b2 signaling pathway, and integrin-\u03b21 (ITGB1), a receptor of collagen, was highly expressed in bone marrow mesenchymal stem cells (BMSCs). Further analysis showed genes such as COL2A1 and Tenascin C (TNC) that interacted with ITGB1 were significantly enriched in extracellular matrix (ECM) structural constituents in the chondrogenic induction group. Knockdown of ITGB1 led to the downregulation of cartilage-specific genes (SOX9, ACAN, COL2A1), SMAD2 and TNC, as well as the downregulation of phosphorylation of SMAD2\/3. Knockdown of TNC also resulted in the decrease of cartilage markers, ITGB1 and the SMAD2\/3 phosphorylation but overexpression of TNC showed the opposite trend. Finally, in vitro and in vivo experiments confirmed the involvement of ITGB1 and TNC in collagen-mediated chondrogenic differentiation and cartilage regeneration. In summary, we demonstrated that ITGB1 was a crucial receptor for chondrogenic differentiation of BMSCs induced by collagen hydrogel. It can activate TGF-SMAD2\/3 signaling, followed by impacting TNC expression, which in turn promotes the interaction of ITGB1 and TGF-SMAD2\/3 signaling to enhance chondrogenesis. These may provide concernful support for cartilage tissue engineering and biomaterials development.<\/jats:p>","DOI":"10.1093\/rb\/rbae017","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T11:36:08Z","timestamp":1708860968000},"source":"Crossref","is-referenced-by-count":25,"title":["Role of integrin \u03b21 and tenascin C mediate TGF-SMAD2\/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel"],"prefix":"10.1093","volume":"11","author":[{"given":"Yuanjun","family":"Huang","sequence":"first","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Life Science Institute, Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Life Science Institute, Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University , Nanning 530021, China"},{"name":"Life Science Institute, Guangxi Medical University , Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"2024032405151550600_rbae017-B1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/jars.2002.32839","article-title":"Articular cartilage defects in 1,000 knee arthroscopies","volume":"18","author":"Hjelle","year":"2002","journal-title":"Arthroscopy"},{"key":"2024032405151550600_rbae017-B2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2174\/1874325001408010346","article-title":"A 5-year follow-up after cartilage repair in the knee using a platelet-rich plasma-immersed polymer-based 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