{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:56:27Z","timestamp":1779256587497,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":155,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82204672"],"award-info":[{"award-number":["82204672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82204322"],"award-info":[{"award-number":["82204322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82104480"],"award-info":[{"award-number":["82104480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cancer is one of the most challenging diseases in the world. Recently, iron oxide nanoparticles (IONPs) are emerging materials with rapid development and high application value, and have shown great potential on tumor therapy due to their unique magnetic and biocompatible properties. However, some data hint us that IONPs were toxic to normal cells and vital organs. Thus, more data on biosafety evaluation is urgently needed. In this study, we compared the effects of silicon-coated IONPs (Si-IONPs) on two cell types: the tumor cells (Hela) and the normal cells (HEK293T, as 293\u2009T for short), compared differences of protein composition, allocation and physical characteristics between these two cells. The major findings of our study pointed out that 293\u2009T cells death occurred more significant than that of Hela cells after Si-IONPs treatment, and the rate and content of endocytosis of Si-IONPs in 293\u2009T cells was more prominent than in Hela cells. Our results also showed Si-IONPs significant promoted the production of reactive oxygen species and disturbed pathways related to oxidative stress, iron homeostasis, apoptosis and ferroptosis in both two types of cells, however, Hela cells recovered from these disturbances more easily than 293\u2009T. In conclusion, compared with Hela cells, IONPs are more likely to induce 293\u2009T cells death and Hela cells have their own unique mechanisms to defense invaders, reminding scientists that future in vivo and in vitro studies of nanoparticles need to be cautious, and more safety data are needed for further clinical treatment.<\/jats:p>","DOI":"10.1093\/rb\/rbae065","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:11:45Z","timestamp":1717445505000},"source":"Crossref","is-referenced-by-count":6,"title":["Comparative time-dependent proteomics reveal the tolerance of cancer cells to magnetic iron oxide nanoparticles"],"prefix":"10.1093","volume":"11","author":[{"given":"Yanqing","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongping","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University , Zhengzhou 450002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengchao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0105","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700, China"},{"name":"Department of Nephrology, Shenzhen key Laboratory of Kidney Diseases, and Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"2024062605570769200_rbae065-B1","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/s41598-018-19628-z","article-title":"Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings","volume":"8","author":"Feng","year":"2018","journal-title":"Sci Rep"},{"key":"2024062605570769200_rbae065-B2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.addr.2019.01.005","article-title":"Iron oxide nanoparticles: diagnostic, therapeutic and theranostic applications","volume":"138","author":"Dadfar","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"2024062605570769200_rbae065-B3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/13543776.2022.2109413","article-title":"Iron oxide nanoparticles for biomedical applications: an updated patent review (2015-2021)","volume":"32","author":"Mao","year":"2022","journal-title":"Expert Opin Ther Pat"},{"key":"2024062605570769200_rbae065-B4","doi-asserted-by":"crossref","first-page":"174860","DOI":"10.1016\/j.ejphar.2022.174860","article-title":"Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway","volume":"921","author":"Chen","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"2024062605570769200_rbae065-B5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12011-014-9972-0","article-title":"Iron oxide nanoparticles induce oxidative stress, DNA damage, and caspase activation in the human breast cancer cell line","volume":"159","author":"Alarifi","year":"2014","journal-title":"Biol Trace Elem Res"},{"key":"2024062605570769200_rbae065-B6","doi-asserted-by":"crossref","first-page":"111931","DOI":"10.1016\/j.colsurfb.2021.111931","article-title":"Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field","volume":"206","author":"Iliasov","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2024062605570769200_rbae065-B7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jconrel.2020.01.048","article-title":"Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy","volume":"320","author":"Guan","year":"2020","journal-title":"J Control Release"},{"key":"2024062605570769200_rbae065-B8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1021\/acs.nanolett.6b04060","article-title":"Switching apoptosis to ferroptosis: metal-organic network for high-efficiency anticancer therapy","volume":"17","author":"Zheng","year":"2017","journal-title":"Nano Lett"},{"key":"2024062605570769200_rbae065-B9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nnano.2016.164","article-title":"Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth","volume":"11","author":"Kim","year":"2016","journal-title":"Nat Nanotechnol"},{"key":"2024062605570769200_rbae065-B10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.freeradbiomed.2017.09.002","article-title":"Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma","volume":"112","author":"Ou","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"2024062605570769200_rbae065-B11","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.3390\/molecules27133970","article-title":"Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines","volume":"27","author":"Fern\u00e1ndez-Acosta","year":"2022","journal-title":"Molecules"},{"key":"2024062605570769200_rbae065-B12","doi-asserted-by":"crossref","first-page":"e202100656","DOI":"10.1002\/cmdc.202100656","article-title":"Enhancement of CD8+ T-cell-mediated tumor immunotherapy via magnetic hyperthermia","volume":"17","author":"Zhang","year":"2022","journal-title":"ChemMedChem"},{"key":"2024062605570769200_rbae065-B13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/jmri.1880040508","article-title":"Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide","volume":"4","author":"Hamm","year":"1994","journal-title":"J Magn Reson Imaging"},{"key":"2024062605570769200_rbae065-B14","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.2174\/13816128113199990409","article-title":"Interactions of iron oxide nanoparticles with the immune system: challenges and opportunities for their use in nano-oncology","volume":"19","author":"Baiu","year":"2013","journal-title":"Curr Pharm Des"},{"key":"2024062605570769200_rbae065-B15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.lfs.2019.01.056","article-title":"Toxic effects of magnetic nanoparticles on normal cells and organs","volume":"220","author":"Jiang","year":"2019","journal-title":"Life Sci"},{"key":"2024062605570769200_rbae065-B16","doi-asserted-by":"crossref","first-page":"e2100330","DOI":"10.1002\/pmic.202100330","article-title":"Targeted proteomics on its way to discovery","volume":"22","author":"Mendes","year":"2022","journal-title":"Proteomics"},{"key":"2024062605570769200_rbae065-B17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-0716-1024-4_8","article-title":"Quantitative mass spectrometry-based proteomics: an overview","volume":"2228","author":"Rozanova","year":"2021","journal-title":"Methods Mol Biol"},{"key":"2024062605570769200_rbae065-B18","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1021\/nn3052499","article-title":"Emerging techniques in proteomics for probing nano-bio interactions","volume":"6","author":"Lai","year":"2012","journal-title":"ACS Nano"},{"key":"2024062605570769200_rbae065-B19","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.colsurfb.2018.04.021","article-title":"A nano-bio interfacial protein corona on silica nanoparticle","volume":"167","author":"Zhang","year":"2018","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2024062605570769200_rbae065-B20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jpha.2022.07.002","article-title":"A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers","volume":"12","author":"Meng","year":"2022","journal-title":"J Pharm Anal"},{"key":"2024062605570769200_rbae065-B21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1570163813666161221141402","article-title":"ICP-MS: analytical method for identification and detection of elemental impurities","volume":"14","author":"Mittal","year":"2017","journal-title":"Curr Drug Discov Technol"},{"key":"2024062605570769200_rbae065-B22","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024062605570769200_rbae065-B23","doi-asserted-by":"crossref","first-page":"8810785","DOI":"10.1155\/2020\/8810785","article-title":"The molecular mechanisms of regulating oxidative stress-induced ferroptosis and therapeutic strategy in tumors","volume":"2020","author":"Zhu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"2024062605570769200_rbae065-B24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41420-022-00902-z","article-title":"The NSUN5-FTH1\/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Death Discov"},{"key":"2024062605570769200_rbae065-B25","first-page":"1449","article-title":"Cell type-specific response to high intracellular loading of polyacrylic acid-coated magnetic nanoparticles","volume":"10","author":"Lojk","year":"2015","journal-title":"Int J Nanomed"},{"key":"2024062605570769200_rbae065-B26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.freeradbiomed.2021.04.024","article-title":"H-ferritin suppression and pronounced mitochondrial respiration make hepatocellular carcinoma cells sensitive to RSL3-induced ferroptosis","volume":"169","author":"Asperti","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2024062605570769200_rbae065-B27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1186\/s12935-021-02420-x","article-title":"FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis","volume":"21","author":"Hu","year":"2021","journal-title":"Cancer Cell Int"},{"key":"2024062605570769200_rbae065-B28","doi-asserted-by":"crossref","first-page":"833642","DOI":"10.3389\/fcvm.2022.833642","article-title":"Identification of HMOX1 as a critical ferroptosis-related gene in atherosclerosis","volume":"9","author":"Wu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2024062605570769200_rbae065-B29","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024062605570769200_rbae065-B30","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"2024062605570769200_rbae065-B31","doi-asserted-by":"crossref","first-page":"111202","DOI":"10.1016\/j.biopha.2020.111202","article-title":"EF24 induces ferroptosis in osteosarcoma cells through HMOX1","volume":"136","author":"Lin","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2024062605570769200_rbae065-B32","doi-asserted-by":"crossref","first-page":"119935","DOI":"10.1016\/j.lfs.2021.119935","article-title":"HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis","volume":"284","author":"Meng","year":"2021","journal-title":"Life Sci"},{"key":"2024062605570769200_rbae065-B33","doi-asserted-by":"crossref","first-page":"897791","DOI":"10.3389\/fphar.2022.897791","article-title":"Honokiol induces ferroptosis by upregulating HMOX1 in acute myeloid leukemia cells","volume":"13","author":"Lai","year":"2022","journal-title":"Front Pharmacol"},{"key":"2024062605570769200_rbae065-B34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11010-020-03973-7","article-title":"Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells","volume":"476","author":"Zhang","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"2024062605570769200_rbae065-B35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.tcb.2014.03.005","article-title":"Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells","volume":"24","author":"Rasola","year":"2014","journal-title":"Trends Cell Biol"},{"key":"2024062605570769200_rbae065-B36","doi-asserted-by":"crossref","first-page":"585047","DOI":"10.3389\/fonc.2020.585047","article-title":"The mitochondrial chaperone TRAP1 as a candidate target of oncotherapy","volume":"10","author":"Xie","year":"2020","journal-title":"Front Oncol"},{"key":"2024062605570769200_rbae065-B37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/biom10010135","article-title":"Modulation of mitochondrial metabolic reprogramming and oxidative stress to overcome chemoresistance in cancer","volume":"10","author":"Avolio","year":"2020","journal-title":"Biomolecules"},{"key":"2024062605570769200_rbae065-B38","doi-asserted-by":"crossref","first-page":"e13145","DOI":"10.1111\/jfbc.13145","article-title":"Understanding oxidants and antioxidants: classical team with new players","volume":"44","author":"Ali","year":"2020","journal-title":"J Food Biochem"},{"key":"2024062605570769200_rbae065-B39","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41568-018-0005-8","article-title":"Revisiting the role of efflux pumps in multidrug-resistant cancer","volume":"18","author":"Robey","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"2024062605570769200_rbae065-B40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jconrel.2020.08.036","article-title":"Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications","volume":"328","author":"Frt\u00fas","year":"2020","journal-title":"J Control Release"},{"key":"2024062605570769200_rbae065-B41","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1039\/D3NA00071K","article-title":"Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells","volume":"5","author":"Uzhytchak","year":"2023","journal-title":"Nanoscale Adv"},{"key":"2024062605570769200_rbae065-B42","doi-asserted-by":"crossref","first-page":"114828","DOI":"10.1016\/j.addr.2023.114828","article-title":"Lysosomal nanotoxicity: impact of nanomedicines on lysosomal function","volume":"197","author":"Uzhytchak","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"2024062605570769200_rbae065-B43","first-page":"790117","article-title":"In vivo biodistribution of iron oxide nanoparticles: an overview","volume":"7901","author":"Tate","year":"2011","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"2024062605570769200_rbae065-B44","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.jmmm.2009.02.068","article-title":"Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration","volume":"321","author":"Tietze","year":"2009","journal-title":"J Magn Magn Mater"},{"key":"2024062605570769200_rbae065-B45","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s10967-012-2173-4","article-title":"Biodistribution of ultra small superparamagnetic iron oxide nanoparticles in BALB mice","volume":"295","author":"Shanehsazzadeh","year":"2013","journal-title":"J Radioanal Nucl Chem"},{"key":"2024062605570769200_rbae065-B46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/01.rli.0000197669.80475.dd","article-title":"Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent","volume":"41","author":"Bourrinet","year":"2006","journal-title":"Invest Radiol"},{"key":"2024062605570769200_rbae065-B47","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2174\/1389201022666210914122846","article-title":"Protective effects of curcumin against iron-induced toxicity","volume":"23","author":"Moinipour","year":"2022","journal-title":"Curr Pharm Biotechnol"},{"key":"2024062605570769200_rbae065-B48","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/01480545.2012.720988","article-title":"Biochemical alterations induced by acute oral doses of iron oxide nanoparticles in wistar rats","volume":"36","author":"Kumari","year":"2013","journal-title":"Drug Chem Toxicol"},{"key":"2024062605570769200_rbae065-B49","doi-asserted-by":"crossref","first-page":"29417","DOI":"10.3390\/ijms161226173","article-title":"Exposure to iron oxide nanoparticles coated with phospholipid-based polymeric micelles induces biochemical and histopathological pulmonary changes in mice","volume":"16","author":"Radu Balas","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2024062605570769200_rbae065-B50","first-page":"373","article-title":"Toxic effects of the Fe2O3 nanoparticles on the liver and lung tissue","volume":"116","author":"Sadeghi","year":"2015","journal-title":"Bratisl Lek Listy"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbae065\/58086987\/rbae065.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbae065\/58333909\/rbae065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbae065\/58333909\/rbae065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:57:49Z","timestamp":1719381469000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbae065\/7687804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":50,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbae065","relation":{},"ISSN":["2056-3426"],"issn-type":[{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"rbae065"}}