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This procedure typically requires autologous small-diameter vascular grafts. However, the limited availability of the donor vessels and associated trauma during tissue harvest underscore the necessity for artificial arterial alternatives. Herein, decellularized bovine intercostal arteries were successfully fabricated with lengths ranging from 15 to 30 cm, which also closely match the inner diameters of human coronary arteries. These decellularized arterial grafts exhibited great promise following poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) grafting from the inner surface. Such surface modification endowed the decellularized arteries with superior mechanical strength, enhanced anticoagulant properties and improved biocompatibility, compared to the decellularized bovine intercostal arteries alone, or even those decellularized grafts modified with both heparin and vascular endothelial growth factor. After replacement of the carotid arteries in rabbits, all surface-modified vascular grafts have shown good patency within 30\u2009days post-implantation. Notably, strong signal was observed after \u03b1-SMA immunofluorescence staining on the PMPC-grafted vessels, indicating significant potential for regenerating the vascular smooth muscle layer and thereby restoring full structures of the artery. Consequently, the decellularized bovine intercostal arteries surface modified by PMPC can emerge as a potent candidate for small-diameter artificial blood vessels, and have shown great promise to serve as viable substitutes of arterial autografts.<\/jats:p>","DOI":"10.1093\/rb\/rbae098","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T15:54:37Z","timestamp":1724169277000},"source":"Crossref","is-referenced-by-count":5,"title":["Polyzwitterion-grafted decellularized bovine intercostal arteries as new substitutes of small-diameter arteries for vascular regeneration"],"prefix":"10.1093","volume":"11","author":[{"given":"Yuan","family":"Xia","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080, 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Guangzhou 510160, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou 510160, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daping","family":"Quan","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Centre for Functional Biomaterials, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University , Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Song","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080, China"},{"name":"National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, NHC key Laboratory of Assisted Circulation and Vascular Diseases (Sun Yat-sen University), Key Laboratory of Assisted Circulation and Vascular Diseases, Chinese Academy of Medical Sciences, Guangdong Engineering Technology Centre for Diagnosis and Treatment of Vascular Diseases , Guangzhou 510080, China"},{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-9148","authenticated-orcid":false,"given":"Ying","family":"Bai","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Centre for Functional Biomaterials, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University , Guangzhou 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