{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:56:28Z","timestamp":1779256588686,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171349"],"award-info":[{"award-number":["32171349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201906240083"],"award-info":[{"award-number":["201906240083"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ23H060005"],"award-info":[{"award-number":["LQ23H060005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent studies have indicated that demineralized cortical bone (DCB) may be used to repair tendons and ligaments, such as the patellar tendon and anterior cruciate ligament (ACL). Hydrogen peroxide (H2O2) has been shown to reduce the osteoinductivity of DCB, and heat treatment may also decrease the osteoinductivity of DCB. The purpose of this study was (i) to determine whether heat treatment reduces the osteoinductivity of DCB and (ii) to compare the effectiveness of heat treatment and H2O2 treatment on BMP-2 inactivation. DCB was prepared by immersion in 0.6\u2009N hydrochloric acid, and DCB-H and DCB-HO were prepared by heat treatment (70\u00b0C for 8\u2009h) and H2O2 treatment (3% H2O2 for 8\u2009h), respectively. The surface topographies, elemental distributions and histological structures of the scaffolds were observed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and histological staining. The viability and osteogenic differentiation of TDSCs cultured on the scaffolds were evaluated via live\/dead cell staining and Cell Counting Kit-8 (CCK-8) testing, real-time polymerase chain reaction (RT-PCR) and western bolt (WB) analysis, alkaline phosphatase activity (ALP) and alizarin red S (ARS) staining. The intramuscular implantation of the scaffolds in rats was also used to evaluate the effect of heat treatment and H2O2 treatment on the osteoinductivity of DCB. Our results demonstrated that both treatments removed BMP-2 and osteocalcin (OCN) within the DCB and that DCB-H and DCB-HO had good cytocompatibility and reduced the osteogenic differentiation of TDSCs. Moreover, the in vivo results indicated that the DCB-H and DCB-HO groups had smaller areas of osteoid formation than did the DCB group, and the DCB-HO group had the smallest area among the three groups. Our study demonstrated that heat treatment could reduce the osteoinductivity of DCB, and that H2O2 treatment was more effective than heat treatment.<\/jats:p>","DOI":"10.1093\/rb\/rbae116","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T18:03:59Z","timestamp":1727287439000},"source":"Crossref","is-referenced-by-count":4,"title":["The effects of heat and hydrogen peroxide treatment on the osteoinductivity of demineralized cortical bone: a potential method for preparing tendon\/ligament repair scaffolds"],"prefix":"10.1093","volume":"11","author":[{"given":"Shukun","family":"He","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, 610041,","place":["China"]},{"name":"Department of Orthopedics, First Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou, 310058,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruonan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, Faculty of Laboratory Medicine, Army Medical University , Chongqing, 400038,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangju","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"2024101317314671100_rbae116-B1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nrrheum.2015.26","article-title":"Tendon injury: from biology to tendon repair","volume":"11","author":"Nourissat","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"2024101317314671100_rbae116-B2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40621-020-0231-x","article-title":"Epidemiology of tendon and ligament injuries in Aotearoa\/New Zealand between 2010 and 2016","volume":"7","author":"Clark","year":"2020","journal-title":"Inj Epidemiol"},{"key":"2024101317314671100_rbae116-B3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/s12891-020-03688-2","article-title":"Epidemiology of Achilles tendon surgery in Italy: a nationwide registry study","volume":"21","author":"Longo","year":"2001","journal-title":"BMC Musculoskelet Disord"},{"key":"2024101317314671100_rbae116-B4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/ten.teb.2016.0181","article-title":"A clinical, biological, and biomaterials perspective into tendon injuries and regeneration","volume":"23","author":"Walden","year":"2017","journal-title":"Tissue Eng Part B Rev"},{"key":"2024101317314671100_rbae116-B5","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1111\/jcmm.13186","article-title":"Combination of biochemical and mechanical cues for tendon tissue engineering","volume":"21","author":"Testa","year":"2017","journal-title":"J Cell Mol Med"},{"key":"2024101317314671100_rbae116-B6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bdrc.21041","article-title":"Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm","volume":"99","author":"Yang","year":"2013","journal-title":"Birth Defects Res C Embryo Today"},{"key":"2024101317314671100_rbae116-B7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.arthro.2005.04.112","article-title":"Analysis of outcomes of anterior cruciate ligament repair with 5-year follow-up: allograft versus autograft","volume":"21","author":"Poehling","year":"2005","journal-title":"Arthroscopy J Arthrosc Relat Surg"},{"key":"2024101317314671100_rbae116-B8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/JSA.0b013e3181c0cf8a","article-title":"Allograft tissue in ACL reconstruction","volume":"17","author":"McGuire","year":"2009","journal-title":"Sports Med Arthrosc Rev"},{"key":"2024101317314671100_rbae116-B9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0030-5898(02)00060-3","article-title":"Anterior cruciate ligament reconstruction with allograft tendons","volume":"34","author":"Strickland","year":"2003","journal-title":"Orthop Clin North Am"},{"key":"2024101317314671100_rbae116-B10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1586\/17434440.6.1.61","article-title":"Scaffolds for tendon and ligament repair: review of the efficacy of commercial products","volume":"6","author":"Chen","year":"2009","journal-title":"Expert Rev Med Devices"},{"key":"2024101317314671100_rbae116-B11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-15-3258-0_1","article-title":"Natural sources and applications of demineralized bone matrix in the field of bone and cartilage tissue engineering","volume":"1249","author":"Cho","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"2024101317314671100_rbae116-B12","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.addr.2012.06.008","article-title":"Demineralized bone matrix in bone repair: history and use","volume":"64","author":"Gruskin","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"2024101317314671100_rbae116-B13","doi-asserted-by":"crossref","first-page":"115548","DOI":"10.1016\/j.bone.2020.115548","article-title":"Discovery of bone morphogenetic proteins\u2014a historical perspective","volume":"140","author":"Sampath","year":"2020","journal-title":"Bone"},{"key":"2024101317314671100_rbae116-B14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/036354659602400403","article-title":"Biologic remodeling after anterior cruciate ligament reconstruction using a collagen matrix derived from demineralized bone\u2014an experimental study in the goat model","volume":"24","author":"Jackson","year":"1996","journal-title":"Am J Sports Med"},{"key":"2024101317314671100_rbae116-B15","first-page":"45","article-title":"Bone-demineralized bone\u2013bone graft for ligament reconstruction in rats","volume":"51","author":"Yamada","year":"2004","journal-title":"J Med Dent Sci"},{"key":"2024101317314671100_rbae116-B16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jbm.b.31157","article-title":"Tendon bone healing can be enhanced by demineralized bone matrix: a functional and histological study","volume":"88","author":"Sundar","year":"2009","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"2024101317314671100_rbae116-B17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s12891-016-1323-1","article-title":"Augmentation and repair of tendons using demineralised cortical bone","volume":"17","author":"Elnikety","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"2024101317314671100_rbae116-B18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-799X-8-18","article-title":"In vitro and in vivo evaluation of orthopedic interface repair using a tissue scaffold with a continuous hard tissue-soft tissue transition","volume":"8","author":"Dickerson","year":"2013","journal-title":"J Orthop Surg Res"},{"key":"2024101317314671100_rbae116-B19","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"2024101317314671100_rbae116-B20","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.167.3919.896","article-title":"Dentin matrix transformation: rapid induction of alkaline phosphatase and cartilage","volume":"167","author":"Huggins","year":"1970","journal-title":"Science"},{"key":"2024101317314671100_rbae116-B21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10195-015-0367-6","article-title":"Calcific tendinitis of the rotator cuff: state of the art in diagnosis and treatment","volume":"17","author":"Merolla","year":"2016","journal-title":"J Orthop Traumatol"},{"key":"2024101317314671100_rbae116-B22","doi-asserted-by":"crossref","first-page":"e10172","DOI":"10.1002\/jbm4.10172","article-title":"Heterotopic ossification: a comprehensive review","volume":"3","author":"Meyers","year":"2019","journal-title":"JBMR Plus"},{"key":"2024101317314671100_rbae116-B23","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1016\/S0021-9258(19)38285-7","article-title":"Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily","volume":"265","author":"Sampath","year":"1990","journal-title":"J Biol Chem"},{"key":"2024101317314671100_rbae116-B24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nbt0398-247","article-title":"Role of morphogenetic proteins in skeletal tissue engineering and regeneration","volume":"16","author":"Reddi","year":"1998","journal-title":"Nat Biotechnol"},{"key":"2024101317314671100_rbae116-B25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s11999-013-3325-8","article-title":"Osteogenic gene expression correlates with development of heterotopic ossification in war wounds","volume":"472","author":"Evans","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"2024101317314671100_rbae116-B26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10561-005-3148-2","article-title":"Effects of hydrogen peroxide cleaning procedures on bone graft osteoinductivity and mechanical properties","volume":"6","author":"DePaula","year":"2005","journal-title":"Cell Tissue Bank"},{"key":"2024101317314671100_rbae116-B27","first-page":"562","article-title":"Effect of hydrogen peroxide on osteoinduction by demineralized bone","volume":"35","author":"Carpenter","year":"2006","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"2024101317314671100_rbae116-B28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00774-009-0040-3","article-title":"Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing","volume":"27","author":"Yano","year":"2009","journal-title":"J Bone Miner Metab"},{"key":"2024101317314671100_rbae116-B29","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jbm.a.36261","article-title":"An engineered tendon\/ligament bioscaffold derived from decellularized and demineralized cortical bone matrix","volume":"106","author":"Yang","year":"2018","journal-title":"J Biomed Mater Res A"},{"key":"2024101317314671100_rbae116-B30","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/jbm.a.36662","article-title":"Effects of hydrogen peroxide on biological characteristics and osteoinductivity of decellularized and demineralized bone matrices","volume":"107","author":"Qing","year":"2019","journal-title":"J Biomed Mater Res A"},{"key":"2024101317314671100_rbae116-B31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/(SICI)1097-4636(199607)31:3<365::AID-JBM10>3.0.CO;2-I","article-title":"Kinetics of cortical bone demineralization: controlled demineralization\u2014a new method for modifying cortical bone allografts","volume":"31","author":"Lewandrowski","year":"1996","journal-title":"J Biomed Mater Res"},{"key":"2024101317314671100_rbae116-B32","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jbm.a.10123","article-title":"Characterization of the mechanical properties of demineralized bone","volume":"67","author":"Summitt","year":"2003","journal-title":"J Biomed Mater Res A"},{"key":"2024101317314671100_rbae116-B33","first-page":"937","author":"Shu","year":"2013"},{"key":"2024101317314671100_rbae116-B34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.biomaterials.2015.02.061","article-title":"The utilization of decellularized tendon slices to provide an inductive microenvironment for the proliferation and tenogenic differentiation of stem cells","volume":"52","author":"Ning","year":"2015","journal-title":"Biomaterials"},{"key":"2024101317314671100_rbae116-B35","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/jbm.820140603","article-title":"Tissue-response to dense apatite implants in rats","volume":"14","author":"Denissen","year":"1980","journal-title":"J Biomed Mater Res"},{"key":"2024101317314671100_rbae116-B36","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1600-0501.2004.01055.x","article-title":"Histomorphometry of human sinus floor augmentation using a porous \u03b2-tricalcium phosphate: a prospective study","volume":"15","author":"Zerbo","year":"2004","journal-title":"Clin Oral Implants Res"},{"key":"2024101317314671100_rbae116-B37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00774-005-0623-6","article-title":"The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2","volume":"23","author":"Ohta","year":"2005","journal-title":"J Bone Miner Metab"},{"key":"2024101317314671100_rbae116-B38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1751-1097.2007.072.x","article-title":"IR laser and heat-induced changes in annulus fibrosus collagen structure","volume":"83","author":"Ignatieva","year":"2007","journal-title":"Photochem Photobiol"},{"key":"2024101317314671100_rbae116-B39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s13239-017-0334-x","article-title":"The impact of heat treatment on porcine heart valve leaflets","volume":"9","author":"Hepfer","year":"2018","journal-title":"Cardiovasc Eng Technol"},{"key":"2024101317314671100_rbae116-B40","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/SLA.0b013e318291da85","article-title":"Burn injury enhances bone formation in heterotopic ossification model","volume":"259","author":"Peterson","year":"2014","journal-title":"Ann Surg"},{"key":"2024101317314671100_rbae116-B41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.actbio.2016.12.012","article-title":"Delivery vehicle effects on bone regeneration and heterotopic ossification induced by high dose BMP-2","volume":"49","author":"Krishnan","year":"2017","journal-title":"Acta Biomater"},{"key":"2024101317314671100_rbae116-B42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41368-018-0021-2","article-title":"Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-\u03b21\/BMP-2 activity","volume":"10","author":"Asparuhova","year":"2018","journal-title":"Int J Oral Sci"},{"key":"2024101317314671100_rbae116-B43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.humpath.2017.03.005","article-title":"Vascular patterning in human heterotopic ossification","volume":"63","author":"Cocks","year":"2017","journal-title":"Hum Pathol"},{"key":"2024101317314671100_rbae116-B44","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1152\/physrev.1989.69.3.990","article-title":"Osteocalcin and matrix Gla protein\u2014vitamin K-dependent proteins in bone","volume":"69","author":"Hauschka","year":"1989","journal-title":"Physiol Rev"},{"key":"2024101317314671100_rbae116-B45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/03008208909049995","article-title":"Gla-containing proteins of bone","volume":"21","author":"Price","year":"1989","journal-title":"Connect Tissue Res"},{"key":"2024101317314671100_rbae116-B46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/ijms21207513","article-title":"Functions of osteocalcin in bone, pancreas, testis, and muscle","volume":"21","author":"Komori","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2024101317314671100_rbae116-B47","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/382448a0","article-title":"Increased bone formation in osteocalcin-deficient mice","volume":"382","author":"Ducy","year":"1996","journal-title":"Nature"},{"key":"2024101317314671100_rbae116-B48","doi-asserted-by":"crossref","first-page":"e1008586","DOI":"10.1371\/journal.pgen.1008586","article-title":"Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass","volume":"16","author":"Moriishi","year":"2020","journal-title":"PLoS Genet"},{"key":"2024101317314671100_rbae116-B49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jbiomech.2018.08.014","article-title":"Structural role of osteocalcin and osteopontin in energy dissipation in bone","volume":"80","author":"Nikel","year":"2018","journal-title":"J Biomech"},{"key":"2024101317314671100_rbae116-B50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/jcmm.12007","article-title":"Identity of tendon stem cells\u2014how much do we know?","volume":"17","author":"Lui","year":"2013","journal-title":"J Cell Mol Med"},{"key":"2024101317314671100_rbae116-B51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2016.01.007","article-title":"Tendon-derived stem cells undergo spontaneous tenogenic differentiation","volume":"341","author":"Guo","year":"2016","journal-title":"Exp Cell Res"},{"key":"2024101317314671100_rbae116-B52","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s12015-011-9276-0","article-title":"Tendon-derived stem cells (TDSCs): from basic science to potential roles in tendon pathology and tissue engineering applications","volume":"7","author":"Lui","year":"2011","journal-title":"Stem Cell Rev Rep"},{"key":"2024101317314671100_rbae116-B53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10856-017-6017-1","article-title":"Osteoinduction and -conduction through absorbable bone substitute materials based on calcium sulfate: in vivo biological behavior in a rabbit model","volume":"29","author":"Pforringer","year":"2018","journal-title":"J Mater Sci Mater Med"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbae116\/59341503\/rbae116.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbae116\/59738930\/rbae116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbae116\/59738930\/rbae116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T17:32:22Z","timestamp":1728840742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbae116\/7775431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":53,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbae116","relation":{},"ISSN":["2056-3426"],"issn-type":[{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"rbae116"}}