{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:15:19Z","timestamp":1791947719552,"version":"4.3.4"},"reference-count":38,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":273,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 32071320"],"award-info":[{"award-number":["NSFC 32071320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poor wound healing in diabetics is primarily caused by persistently high levels of inflammation and recurrent bacterial infections. The catalytic therapy technique based on nanozyme medicine has emerged as a beacon of hope for patients with diabetic wounds. However, the use of a single-atom nanozyme may still have limitations, including nanozyme burst release, immunological clearance and insufficient antibacterial activity. To address the aforementioned problems, we provide a new nano-catalytic therapeutic agent for diabetic skin ulcers that incorporates a single-atom nanozyme with high antioxidant activity into a metal\u2013organic framework (ZIF-Cu\/C-dots). First, a Cu single-atom nanozyme supported by ultra-small carbon dots (Cu\/C-dots) with high antioxidant activity was created. A nanozyme-integrated metal\u2013organic framework was then created, utilizing Cu\/C-dots as ligands and Zn2+ as the core metal. Cu\/C-dots have good oxidase-like activity, shielding the biological system from ROS damage and reducing the expression of TNF-\u03b1 and IL-1\u03b2. Zn2+ also has good antibacterial activity (the antibacterial rate was more than 90%). This integrated technique prevents nanozyme aggregation, improves nanozyme biocompatibility, slows down the breakdown of ZIF and allows for the regulated release of Cu\/C-dots and Zn2+ as needed. Finally, in vivo studies have shown that ZIF-Cu\/C-dots can effectively alleviate inflammation at the site of diabetic wounds, accelerate vascular regeneration, promote collagen deposition and enhance tissue remodeling, serving as a novel nano-catalytic platform for the treatment of wounds that are difficult to heal.<\/jats:p>","DOI":"10.1093\/rb\/rbae119","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T07:18:53Z","timestamp":1727421533000},"source":"Crossref","is-referenced-by-count":39,"title":["MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing"],"prefix":"10.1093","volume":"11","author":[{"given":"Sheng","family":"Dai","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]},{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, PLA , Beijing 100074,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]},{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]},{"name":"Shandong Provincial Engineering Research Center of Novel Pharmaceutical Excipients and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University , Dezhou 253023,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaogui","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]},{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]},{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu, Sichuan 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"2024112116014593300_rbae119-B1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3390\/nano10061234","article-title":"Nanoparticle-based therapeutic approach for diabetic wound 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