{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:41:16Z","timestamp":1793515276926,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071079"],"award-info":[{"award-number":["82071079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis, a widespread inflammatory disease, is the major cause of tooth loss in adults. While mechanical periodontal therapy benefits the periodontal disease treatment, adjunctive periodontal therapy is also necessary. Topically applied anti-inflammatory agents have gained considerable attention in periodontitis therapy. Although azithromycin (AZM) possesses excellent anti-inflammatory properties, its bioavailability is limited owing to poor water solubility and the absence of sustained release mechanisms. Herein, we synthesized biodegradable microspheres (AZM@PLGA-SF) for sustained AZM release to locally ameliorate periodontal inflammation and facilitate periodontal tissue regeneration. AZM was encapsulated in poly (lactic-co-glycolic acid) (PLGA) microspheres (AZM@PLGA) using single emulsion-solvent evaporation, followed by surface coating with silk fibroin (SF) via electrostatic adsorption, reducing the initial burst release of AZM. In vivo, local treatment with AZM@PLGA-SF microspheres significantly reduced periodontal inflammation and restored periodontal tissue to healthy levels. Mechanically, the formulated microspheres regulated the periodontal inflammatory microenvironment by reducing the levels of pro-inflammatory cytokines (tumor necrosis factor -\u03b1, interleukin [IL]-6, interferon-\u03b3, IL-2, and IL-17A) in gingival crevicular fluid and promoted the expression of anti-inflammatory cytokines (IL-4 and IL-10). AZM@PLGA-SF microspheres demonstrated excellent biological safety. Therefore, we introduce an anti-inflammatory therapy for periodontitis with substantial potential for mitigating periodontal inflammation and encouraging the repair and regeneration of periodontal tissues.<\/jats:p>","DOI":"10.1093\/rb\/rbae146","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:28:39Z","timestamp":1734046119000},"source":"Crossref","is-referenced-by-count":18,"title":["Azithromycin-loaded PLGA microspheres coated with silk fibroin ameliorate inflammation and promote periodontal tissue regeneration"],"prefix":"10.1093","volume":"12","author":[{"given":"Zhaoguang","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]},{"name":"Department of Preventive Dentistry, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University , Guangzhou 510013, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine , Changsha, Hunan 410208, PR","place":["China"]},{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, MA 21205,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengye","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry , Ann Arbor, MI 48105,","place":["USA"]},{"name":"Periodontal and Implant Microsurgery Academy (PiMA), University of Michigan School of Dentistry , Ann Arbor, MI 48105,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying ChengYao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University , Tianjin 300041, PR","place":["China"]},{"name":"Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction , Tianjin 300041, PR","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-2658","authenticated-orcid":false,"given":"Dayong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070, PR","place":["China"]},{"name":"Tianjin Medical University Institute of Stomatology , Tianjin 300070, PR","place":["China"]},{"name":"School and Hospital of Stomatology, Hebei Medical University & Hebei Key Laboratory of Stomatology & Hebei Clinical Research Center for Oral Diseases , Shijiazhuang, Hebei 050011, 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