{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:42:43Z","timestamp":1783654963869,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":132,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFF1503800"],"award-info":[{"award-number":["2024YFF1503800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Department of Guangdong Province","award":["STKJ2021016"],"award-info":[{"award-number":["STKJ2021016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A big diameter bioresorbable scaffold is expected to be used for treatment of vessel stenosis of children with congenital heart disease to adapt the growth characteristics of vessel of children and avoid the late adverse events of permanent stent implanted in children. However, it is challenging to fabricate a big diameter bioresorbable scaffold that is appropriate for percutaneous implantation with enough mechanical performance and can be smoothly delivered in children\u2019s small vessel. In this study, a novel iron big and bioresorbable Scaffold (BBS) for pulmonary artery stenosis of children with congenital cardiovascular diseases was fabricated and evaluated. The BBS was made of nitrided iron tube and processed by laser cutting and polishing. The testing results of radial strength, recoil, shortening, maximal expansion diameter and side-branch accessability illustrated the BBS has good mechanical performance. The animal study showed that the percentage of area stenosis of BBSs was 18.1\u2009\u00b1\u20098.6%, 20.2\u2009\u00b1\u20095.9% and 20.4\u2009\u00b1\u20096.1% at 28, 90 and 180\u2009days after implantation in 17 rabbits, and no malposition, thrombus, dissection or tissue necrosis in the rabbit model was detected by micro-CT, STEM and histological examinations. An \u03c68\u2009\u00d7\u200923\u2009mm BBS was implanted into a 55-month-old child with left pulmonary stenosis, and multiple spiral CT was conducted. No lumen area loss appeared at 1- and 2-year follow-ups in this first-in-man study. It suggested that the BBS might be a new strategy for the therapy of pulmonary artery stenosis in children.<\/jats:p>","DOI":"10.1093\/rb\/rbaf041","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:49:42Z","timestamp":1747147782000},"source":"Crossref","is-referenced-by-count":4,"title":["A novel iron bioresorbable scaffold: a potential strategy for pulmonary artery stenosis"],"prefix":"10.1093","volume":"12","author":[{"given":"Li","family":"Qin","sequence":"first","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijin","family":"Yu","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, Guangdong Technion-Israel Institute of Technology , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Queen Mary School, Nanchang University , Nanchang 330038,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Biotechnology and Food Engineering Department, Guangdong Technion-Israel Institute of Technology , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Fu","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetao","family":"Ou","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, Guangdong Technion-Israel Institute of Technology , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Shi","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Si","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, Guangdong Technion-Israel Institute of Technology , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Shen","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, Guangdong Technion-Israel Institute of Technology , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-1592","authenticated-orcid":false,"given":"Limei","family":"Cha","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, Guangdong Technion-Israel Institute of Technology , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Biotyx Medical (Shenzhen) Co., Ltd., Lifetech Scientific (Shenzhen) Co., Ltd. , Shenzhen 518110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"2025062621332202600_rbaf041-B1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.athoracsur.2020.01.007","article-title":"Pulmonary 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