{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:13:55Z","timestamp":1793031235383,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":282,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Foundation of Tianjin Eye Hospital","award":["YKPY2205"],"award-info":[{"award-number":["YKPY2205"]}]},{"name":"Tianjin Science and Technology","award":["22JCZDJC00280"],"award-info":[{"award-number":["22JCZDJC00280"]}]},{"name":"Tianjin Key Medical Discipline Construction","award":["TJYXZDXK-3-004A-3"],"award-info":[{"award-number":["TJYXZDXK-3-004A-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High myopia severely threatens the visual health of adolescents, with pathological features of decreased collagen aggregation and scleral thinning, ultimately leading to axial elongation on preretinal imaging. Fibroblasts play crucial roles in scleral remodelling and myopia prevention. In this work, we developed a fibroblast-loaded carboxymethyl chitosan-aldehyde hyaluronic acid (CMCS-HA-CHO) injectable hydrogel for anti-scleral remodelling. The CMCS-HA-CHO hydrogel is formed through simple mixing under mild conditions via a Schiff base reaction between CMCS and HA-CHO. The CMCS-HA-CHO hydrogel can be injected into a posterior sclera with a low modulus, and the increasing modulus over time provides good mechanical support to the sclera. The hydrogel demonstrated excellent cytocompatibility and haemocompatibility, and the encapsulated fibroblasts maintained good activity. Both the hydrogel and fibroblast-loaded hydrogel effectively shortened the axial length of myopic eyes in guinea pigs in a deprivation model. In particular, the fibroblast-loaded hydrogel had the best therapeutic effect because of the synergy of cell therapy and mechanical support, which always shortened the eye axis within 4\u2009weeks. Furthermore, increased collagen secretion promoted by fibroblasts can increase the thickness of the sclera and improve its biomechanical properties, ultimately repairing the physiological structure of the sclera. This fibroblast-loaded injectable hydrogel may represent a promising clinical approach for controlling myopia progression.<\/jats:p>","DOI":"10.1093\/rb\/rbaf096","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:49:49Z","timestamp":1759837789000},"source":"Crossref","is-referenced-by-count":7,"title":["Fibroblast-loaded carboxymethyl chitosan\u2014aldehyde hyaluronic acid injectable hydrogel for scleral remodelling to prevent development of myopia"],"prefix":"10.1093","volume":"12","author":[{"given":"Jingwen","family":"Hui","sequence":"first","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Tang","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]},{"name":"School of Medicine, Nankai University , Tianjin 300350,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University , Tianjin 300350,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoge","family":"Han","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University , Tianjin 300350,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongfeng","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University , Tianjin 300350,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhong","family":"Han","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9922-3946","authenticated-orcid":false,"given":"Xiaoyong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University , Tianjin 300070,","place":["China"]},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute , Tianjin 300020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2025111103191443600_rbaf096-B1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI prevention of myopia and its progression","volume":"62","author":"Jonas","year":"2021","journal-title":"Invest Ophthalmol Vis 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