{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:53:41Z","timestamp":1787982821136,"version":"build-2784847793"},"reference-count":81,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":300,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62271104"],"award-info":[{"award-number":["62271104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871068"],"award-info":[{"award-number":["61871068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62231025"],"award-info":[{"award-number":["62231025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2020-MS-255"],"award-info":[{"award-number":["2020-MS-255"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is a chronic inflammatory disease affecting periodontal supporting tissues. Untreated, it causes irreversible alveolar bone destruction, ultimately leading to tooth loss. Periodontitis-associated pathogenic bacteria\/metabolites and pro-inflammatory factors can initiate or exacerbate systemic disease through the circulation. Endothelial cells, forming the interface between circulation and tissues, play a key role in disease progression. As microfluidic organ chips enable the establishment of tissue\u2013tissue interfaces and simulation of the in vivo microenvironment, we constructed a bone-vessel interface-on-a-chip. Within this physiological model, human bone marrow mesenchymal stem cells (hBMSCs) and human umbilical vein endothelial cells (HUVECs) were successfully co-cultured with high viability. HUVECs formed a confluent monolayer exhibiting selective vascular permeability. Osteo-differentiated hBMSCs expressed alkaline phosphatase, secreted bone-related proteins, and formed mineralized deposits. By introducing the Porphyromonas gingivalis (P. gingivalis) metabolite LPS and the pro-inflammatory factor TNF-\u03b1, we established an inflammatory microenvironment. The chip model subsequently exhibited vascular endothelial intercellular junction disruption, upregulated adhesion protein expression, enhanced monocyte adhesion, impaired vascular endothelial barrier function, and reduced bone-related protein expression. These results demonstrate that bone-vessel interface-on-a-chip can effectively study the effects of periodontitis metabolites and pro-inflammatory factors on the vascular barrier and bone tissue through controlled integration of biochemical and biophysical cues. This model provides a robust platform for investigating endothelial cell-targeted therapies for inflammatory diseases, including periodontitis and associated systemic diseases.<\/jats:p>","DOI":"10.1093\/rb\/rbaf111","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:40:28Z","timestamp":1761568828000},"source":"Crossref","is-referenced-by-count":10,"title":["Biomimetic bone-vessel interface-on-a-chip for simulating periodontal physiological and pathological microenvironment"],"prefix":"10.1093","volume":"12","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"School of Stomatology, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Academician Laboratory of Immune and Oral Development & Regeneration, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Dalian Medical University School and Hospital of Stomatology , Dalian 116000,","place":["China"]},{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Hui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laidi","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Stomatology, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Academician Laboratory of Immune and Oral Development & Regeneration, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Dalian Medical University School and Hospital of Stomatology , Dalian 116000,","place":["China"]},{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Academician Laboratory of Immune and Oral Development & Regeneration, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Dalian Medical University School and Hospital of Stomatology , Dalian 116000,","place":["China"]},{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowu","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Stomatology, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Academician Laboratory of Immune and Oral Development & Regeneration, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Dalian Medical University School and Hospital of Stomatology , Dalian 116000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongju","family":"Mao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-3557","authenticated-orcid":false,"given":"Huiying","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Academician Laboratory of Immune and Oral Development & Regeneration, Dalian Medical University , Dalian 116044,","place":["China"]},{"name":"Dalian Medical University School and Hospital of Stomatology , Dalian 116000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2025121818571816100_rbaf111-B1","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal 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