{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:52:09Z","timestamp":1789735929854,"version":"4.0.1"},"reference-count":84,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2023-152058OB-I00"],"award-info":[{"award-number":["PID2023-152058OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Brain pathologies such as ischemic stroke or traumatic brain injury (TBI) are among the most impactful diseases worldwide. In ischemic stroke, we currently lack truly effective treatments capable of delaying infarct progression, limiting lesion size or stimulating endogenous brain repair mechanisms to promote neurovascular remodeling and functional recovery. Two main barriers continue to limit the clinical translation of therapeutic molecules: the highly restrictive nature of the blood\u2013brain barrier and that many bioactive molecules exhibit low stability at the target site, with half-lives shorter than the therapeutic window. In this study, we developed tunable silk fibroin (SF) films of variable concentration, fabricated via water annealing, that effectively preserve the functional activity of the chemokine CXCL12 (SDF-1\u03b1). The 2% SF formulation provided sustained release of SDF-1\u03b1 for at least 7\u2009days, promoting the in vitro migration of mesenchymal stem cells (MSCs) and low-density bone marrow mononuclear cells (LDBM), the latter containing hematopoietic stem cells. When implanted on the cortical surface, the SDF-1\u03b1-SF films successfully stimulated the guided migration of exogenously administered MSCs and LDBM from subcortical regions into the cerebral cortex. Furthermore, co-implantation of SDF-1\u03b1-SF films with MSCs or LDBM enhanced cell retention at the cortical site, effectively minimizing off-target dispersion. In a photothrombotic model of cortical ischemia, allowing precise control of lesion location and size, SDF-1\u03b1-SF films significantly reduced lesion volume and preserved neuronal function in the somatosensory cortex, as assessed by electrophysiology. Our findings provide proof of concept for using chemokine-releasing biomaterials to actively modulate stem cell migration and retention within the brain, offering strong potential for neuroprotection and tissue remodeling in areas at risk or already affected by damage.<\/jats:p>","DOI":"10.1093\/rb\/rbaf129","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:52:07Z","timestamp":1765284727000},"source":"Crossref","is-referenced-by-count":3,"title":["Stabilization of CXCL12 (SDF-1\u03b1) via silk fibroin films enhances stem cell migration\/retention and functional recovery after stroke"],"prefix":"10.1093","volume":"13","author":[{"given":"Amira","family":"Lekouaghet","sequence":"first","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"S\u00e1nchez-D\u00edez","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"P\u00e9rez-Rigueiro","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]},{"name":"Departamento de Ciencia de Materiales, ETSI Caminos, Universidad Polit\u00e9cnica de Madrid , Madrid 28040,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III , Madrid 28029,","place":["Spain"]},{"name":"Biomaterials and Regenerative Medicine Group, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) , Madrid 28040,","place":["Spain"]},{"name":"Silk Biomed SL , Galapagar 28260,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Rojo","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]},{"name":"Departamento de Ciencia de Materiales, ETSI Caminos, Universidad Polit\u00e9cnica de Madrid , Madrid 28040,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III , Madrid 28029,","place":["Spain"]},{"name":"Biomaterials and Regenerative Medicine Group, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) , Madrid 28040,","place":["Spain"]},{"name":"Silk Biomed SL , Galapagar 28260,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ram\u00edrez-Castillejo","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Ruiz-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Research Support Unit, Real Jard\u00edn Bot\u00e1nico, Consejo Superior de Investigaciones Cient\u00edficas (CSIC) , Madrid 28014,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fivos","family":"Panetsos","sequence":"additional","affiliation":[{"name":"Biomaterials and Regenerative Medicine Group, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) , Madrid 28040,","place":["Spain"]},{"name":"Silk Biomed SL , Galapagar 28260,","place":["Spain"]},{"name":"Neurocomputing and Neurorobotics Research Group, Faculty of Biology and Faculty of Optics, Universidad Complutense de Madrid , Madrid 28040,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo V","family":"Guinea","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]},{"name":"Departamento de Ciencia de Materiales, ETSI Caminos, Universidad Polit\u00e9cnica de Madrid , Madrid 28040,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III , Madrid 28029,","place":["Spain"]},{"name":"Biomaterials and Regenerative Medicine Group, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) , Madrid 28040,","place":["Spain"]},{"name":"Silk Biomed SL , Galapagar 28260,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gonz\u00e1lez-Nieto","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid , Pozuelo de Alarc\u00f3n 28223,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III , Madrid 28029,","place":["Spain"]},{"name":"Silk Biomed SL , Galapagar 28260,","place":["Spain"]},{"name":"Departamento de Tecnolog\u00eda Fot\u00f3nica y Bioingenier\u00eda, ETSI Telecomunicaciones, Universidad Polit\u00e9cnica de Madrid , Madrid 28040,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"2026020103461267200_rbaf129-B1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/STROKEAHA.122.042022","article-title":"Burden of stroke in Europe: an analysis of the global burden of disease study findings from 2010 to 2019","volume":"55","author":"Prendes","year":"2024","journal-title":"Stroke"},{"key":"2026020103461267200_rbaf129-B2","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1001\/jama.2015.3058","article-title":"Acute stroke intervention: a systematic review","volume":"313","author":"Prabhakaran","year":"2015","journal-title":"Jama"},{"key":"2026020103461267200_rbaf129-B3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ana.25493","article-title":"Cell therapy for ischemic stroke: are differences in preclinical and clinical study design responsible for the translational loss of efficacy?","volume":"86","author":"Cui","year":"2019","journal-title":"Ann Neurol"},{"key":"2026020103461267200_rbaf129-B4","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1634\/stemcells.2005-0260","article-title":"Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage","volume":"24","author":"Fran\u00e7ois","year":"2006","journal-title":"Stem Cells"},{"key":"2026020103461267200_rbaf129-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/asheducation-2010.1.1","article-title":"The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization","volume":"2010","author":"Lapidot","year":"2010","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"2026020103461267200_rbaf129-B6","author":"Magnon"},{"key":"2026020103461267200_rbaf129-B7","doi-asserted-by":"crossref","first-page":"598520","DOI":"10.3389\/fcell.2020.598520","article-title":"Endogenous mobilization of mesenchymal stromal cells: a pathway for interorgan communication?","volume":"8","author":"Girousse","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026020103461267200_rbaf129-B8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3324\/haematol.10475","article-title":"Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3","volume":"92","author":"De Becker","year":"2007","journal-title":"Haematologica"},{"key":"2026020103461267200_rbaf129-B9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.stem.2008.03.003","article-title":"Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2","volume":"2","author":"Belema-Bedada","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2026020103461267200_rbaf129-B10","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2008.03.011","article-title":"Nuclear pore composition regulates neural stem\/progenitor cell differentiation in the mouse embryo","volume":"14","author":"Lupu","year":"2008","journal-title":"Dev Cell"},{"key":"2026020103461267200_rbaf129-B11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7150\/thno.4621","article-title":"Innate immunity derived factors as external modulators of the CXCL12 - CXCR4 axis and their role in stem cell homing and mobilization","volume":"3","author":"Ratajczak","year":"2013","journal-title":"Theranostics"},{"key":"2026020103461267200_rbaf129-B12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/978-1-4614-2098-9_11","article-title":"Mobilization and homing of hematopoietic stem cells","volume":"741","author":"Suarez-Alvarez","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"2026020103461267200_rbaf129-B13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/acsabm.3c01058","article-title":"Biomaterials and cell therapy combination in Central nervous system treatments","volume":"7","author":"Giorgi","year":"2024","journal-title":"ACS Appl Bio Mater"},{"key":"2026020103461267200_rbaf129-B14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/polym10020184","article-title":"Hydrogels-assisted cell engraftment for repairing the stroke-damaged brain: chimera or reality","volume":"10","author":"Gonz\u00e1lez-Nieto","year":"2018","journal-title":"Polymers (Basel)"},{"key":"2026020103461267200_rbaf129-B15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.progpolymsci.2007.05.013","article-title":"Silk as a biomaterial","volume":"32","author":"Vepari","year":"2007","journal-title":"Prog Polym Sci"},{"key":"2026020103461267200_rbaf129-B16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.actbio.2016.09.003","article-title":"Safety and tolerability of silk fibroin hydrogels implanted into the mouse brain","volume":"45","author":"Fern\u00e1ndez-Garc\u00eda","year":"2016","journal-title":"Acta Biomater"},{"key":"2026020103461267200_rbaf129-B17","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.3390\/polym15112491","article-title":"Resistance to degradation of silk fibroin hydrogels exposed to neuroinflammatory environments","volume":"15","author":"Yonesi","year":"2023","journal-title":"Polymers (Basel)"},{"key":"2026020103461267200_rbaf129-B18","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1021\/acs.biomac.4c00629","article-title":"Permselectivity of silk fibroin hydrogels for advanced drug delivery neurotherapies","volume":"25","author":"Fern\u00e1ndez-Serra","year":"2024","journal-title":"Biomacromolecules"},{"key":"2026020103461267200_rbaf129-B19","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/nprot.2011.379","article-title":"Materials fabrication from Bombyx mori silk fibroin","volume":"6","author":"Rockwood","year":"2011","journal-title":"Nat Protoc"},{"key":"2026020103461267200_rbaf129-B20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/mabi.201500013","article-title":"The effect of sterilization on silk fibroin biomaterial properties","volume":"15","author":"Rnjak-Kovacina","year":"2015","journal-title":"Macromol Biosci"},{"key":"2026020103461267200_rbaf129-B21","doi-asserted-by":"crossref","first-page":"29634","DOI":"10.1021\/acsomega.2c01579","article-title":"Optically clear silk fibroin films with tunable properties for potential corneal tissue engineering applications: a process-property-function relationship study","volume":"7","author":"Beena","year":"2022","journal-title":"ACS Omega"},{"key":"2026020103461267200_rbaf129-B22","doi-asserted-by":"crossref","first-page":"e6392","DOI":"10.1002\/pat.6392","article-title":"Incorporation of nanoparticles in silk fibroin solution: toward water-stable silk fibroin films possessing silk I structure","volume":"35","author":"Tariq","year":"2024","journal-title":"Polym Adv Technol"},{"key":"2026020103461267200_rbaf129-B23","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1039\/D2SM00340F","article-title":"Unexpected high toughness of Samia cynthia ricini silk gut","volume":"18","author":"Aznar-Cervantes","year":"2022","journal-title":"Soft Matter"},{"key":"2026020103461267200_rbaf129-B24","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1039\/C7GC01254C","article-title":"Straining flow spinning: production of regenerated silk fibers under a wide range of mild coagulating chemistries","volume":"19","author":"Madurga","year":"2017","journal-title":"Green Chem"},{"key":"2026020103461267200_rbaf129-B25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/0271678X15606139","article-title":"Long-term dynamics of somatosensory activity in a stroke model of distal Middle cerebral artery oclussion","volume":"36","author":"Barios","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026020103461267200_rbaf129-B26","doi-asserted-by":"crossref","first-page":"11068","DOI":"10.1073\/pnas.1006375107","article-title":"Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis","volume":"107","author":"Carbajal","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026020103461267200_rbaf129-B27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1172\/JCI15994","article-title":"Disruption of the CXCR4\/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide","volume":"111","author":"Levesque","year":"2003","journal-title":"J Clin Invest"},{"key":"2026020103461267200_rbaf129-B28","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell Pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"2026020103461267200_rbaf129-B29","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1002\/jcb.24148","article-title":"Acetylcholine induces mesenchymal stem cell migration via Ca2+\/PKC\/ERK1\/2 signal pathway","volume":"113","author":"Tang","year":"2012","journal-title":"J Cell Biochem"},{"key":"2026020103461267200_rbaf129-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2005.02.007","article-title":"Stability of acetylcholine chloride solution in autonomic testing","volume":"234","author":"Sletten","year":"2005","journal-title":"J Neurol Sci"},{"key":"2026020103461267200_rbaf129-B31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bpj.2020.06.027","article-title":"Elongation index as a sensitive measure of cell deformation in high-throughput microfluidic systems","volume":"119","author":"Hymel","year":"2020","journal-title":"Biophys J"},{"key":"2026020103461267200_rbaf129-B32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2141.2007.06610.x","article-title":"Recent advances into the understanding of mesenchymal stem cell trafficking","volume":"137","author":"Fox","year":"2007","journal-title":"Br J Haematol"},{"key":"2026020103461267200_rbaf129-B33","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1089\/scd.2014.0269","article-title":"No evidence for circulating mesenchymal stem cells in patients with organ injury","volume":"23","author":"Hoogduijn","year":"2014","journal-title":"Stem Cells Dev"},{"key":"2026020103461267200_rbaf129-B34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.brainres.2005.12.035","article-title":"Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia","volume":"1072","author":"Green","year":"2006","journal-title":"Brain Res"},{"key":"2026020103461267200_rbaf129-B35","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJMoa070240","article-title":"NXY-059 for the treatment of acute ischemic stroke","volume":"357","author":"Shuaib","year":"2007","journal-title":"N Engl J Med"},{"key":"2026020103461267200_rbaf129-B36","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1038\/s41598-025-90888-2","article-title":"Investigating blood-brain barrier penetration and neurotoxicity of natural products for Central nervous system drug development","volume":"15","author":"Kato","year":"2025","journal-title":"Sci Rep"},{"key":"2026020103461267200_rbaf129-B37","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1001\/jama.285.13.1719","article-title":"Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial","volume":"285","author":"Sacco","year":"2001","journal-title":"Jama"},{"key":"2026020103461267200_rbaf129-B38","doi-asserted-by":"crossref","first-page":"2493752","DOI":"10.1155\/2017\/2493752","article-title":"SDF-1\/CXCR4 signaling maintains stemness signature in mouse neural stem\/progenitor cells","volume":"2017","author":"Ho","year":"2017","journal-title":"Stem Cells Int"},{"key":"2026020103461267200_rbaf129-B39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12974-023-02689-x","article-title":"Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke","volume":"20","author":"Wang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"2026020103461267200_rbaf129-B40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2119\/2007-00008.Villa","article-title":"The interleukin-8 (IL-8\/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats","volume":"13","author":"Villa","year":"2007","journal-title":"Mol Med"},{"key":"2026020103461267200_rbaf129-B41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainres.2010.11.087","article-title":"Chemokine-related gene expression in the brain following ischemic stroke: no role for CXCR2 in outcome","volume":"1372","author":"Brait","year":"2011","journal-title":"Brain Res"},{"key":"2026020103461267200_rbaf129-B42","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1124\/jpet.107.127746","article-title":"Stromal cell-derived factor-1 alpha promotes neuroprotection, angiogenesis, and mobilization\/homing of bone marrow-derived cells in stroke rats","volume":"324","author":"Shyu","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"2026020103461267200_rbaf129-B43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13287-018-0865-6","article-title":"cxcl12-engineered endothelial progenitor cells enhance neurogenesis and angiogenesis after ischemic brain injury in mice","volume":"9","author":"Li","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"2026020103461267200_rbaf129-B44","doi-asserted-by":"publisher","first-page":"584565","DOI":"10.1101\/584565","article-title":"Intraventricular CXCL12 is neuroprotective and increases neurogenesis in a murine model of stroke","author":"Zamproni","year":"2019","journal-title":"bioRxiv"},{"key":"2026020103461267200_rbaf129-B45","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/jcbfm.2013.71","article-title":"Inhibition of CXCL12 signaling attenuates the postischemic immune response and improves functional recovery after stroke","volume":"33","author":"Ruscher","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026020103461267200_rbaf129-B46","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1158\/1535-7163.MCT-12-0494","article-title":"A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability","volume":"11","author":"Takekoshi","year":"2012","journal-title":"Mol Cancer Ther"},{"key":"2026020103461267200_rbaf129-B47","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1021\/acsbiomaterials.8b01024","article-title":"In vivo evaluation of engineered Self-Assembling silk fibroin hydrogels after intracerebral injection in a rat stroke model","volume":"5","author":"Gorenkova","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"2026020103461267200_rbaf129-B48","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fncel.2018.00296","article-title":"Cortical reshaping and functional recovery induced by silk fibroin hydrogels-encapsulated stem cells implanted in stroke animals","volume":"12","author":"Fern\u00e1ndez-Garc\u00eda","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"2026020103461267200_rbaf129-B49","doi-asserted-by":"crossref","first-page":"120413","DOI":"10.1016\/j.biomaterials.2020.120413","article-title":"Reinforced-hydrogel encapsulated hMSCs towards brain injury treatment by trans-septal approach","volume":"266","author":"Sultan","year":"2021","journal-title":"Biomaterials"},{"key":"2026020103461267200_rbaf129-B50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biomaterials.2015.05.025","article-title":"Enhancing neurogenesis and angiogenesis with target delivery of stromal cell derived factor-1\u03b1 using a dual ionic pH-sensitive copolymer","volume":"61","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"key":"2026020103461267200_rbaf129-B51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biomaterials.2018.05.009","article-title":"Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in Central nervous system regeneration","volume":"174","author":"Jian","year":"2018","journal-title":"Biomaterials"},{"key":"2026020103461267200_rbaf129-B52","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jbm.b.35170","article-title":"Syndecan-4 and stromal cell-derived factor-1 alpha functionalized endovascular scaffold facilitates adhesion, spreading and differentiation of endothelial colony forming cells and functions under flow and shear stress conditions","volume":"111","author":"Wu","year":"2023","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"2026020103461267200_rbaf129-B53","first-page":"547800","article-title":"SDF-1 bound heparin nanoparticles recruit progenitor cells for their differentiation and promotion of angiogenesis after stroke","volume":"5","author":"Wilson","year":"2023","journal-title":"bioRxiv"},{"key":"2026020103461267200_rbaf129-B54","first-page":"13","article-title":"Engineered extracellular vesicles for ischemic stroke treatment","volume":"4","author":"Ruan","year":"2023","journal-title":"Innovation"},{"key":"2026020103461267200_rbaf129-B55","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1177\/0271678X16649964","article-title":"Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke","volume":"37","author":"Cook","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026020103461267200_rbaf129-B56","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.3727\/096368914X684998","article-title":"The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse","volume":"23","author":"Ju","year":"2014","journal-title":"Cell Transplant"},{"key":"2026020103461267200_rbaf129-B57","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41563-018-0083-8","article-title":"Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke","volume":"17","author":"Nih","year":"2018","journal-title":"Nat Mater"},{"key":"2026020103461267200_rbaf129-B58","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3727\/096368910X498278","article-title":"Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats","volume":"19","author":"Emerich","year":"2010","journal-title":"Cell Transplant"},{"key":"2026020103461267200_rbaf129-B59","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/jbm.a.37409","article-title":"Specific bio-functional CBD-PR1P peptide binding VEGF to collagen hydrogels promotes the recovery of cerebral ischemia in rats","volume":"110","author":"Yin","year":"2022","journal-title":"J Biomed Mater Res A"},{"key":"2026020103461267200_rbaf129-B60","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.3390\/ijms19123782","article-title":"Intracerebral delivery of Brain-Derived neurotrophic factor using HyStem((R))-C hydrogel implants improves functional recovery and reduces neuroinflammation in a rat model of ischemic stroke","volume":"19","author":"Ravina","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026020103461267200_rbaf129-B61","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1021\/acs.biomac.5b00144","article-title":"Sustained delivery of chemokine CXCL12 from chemically modified silk hydrogels","volume":"16","author":"Atterberry","year":"2015","journal-title":"Biomacromolecules"},{"key":"2026020103461267200_rbaf129-B62","first-page":"2157","article-title":"RADA 16-I hydrogel-released CXCL 12 stably promotes stem cell migration","volume":"9","author":"Cheng","year":"2019","journal-title":"J. Tissue Sci. Eng"},{"key":"2026020103461267200_rbaf129-B63","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1021\/bm101421r","article-title":"Mechanisms of controlled release from silk fibroin films","volume":"12","author":"Hines","year":"2011","journal-title":"Biomacromolecules"},{"key":"2026020103461267200_rbaf129-B64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jconrel.2005.12.009","article-title":"Silk fibroin as an organic polymer for controlled drug delivery","volume":"111","author":"Hofmann","year":"2006","journal-title":"J Control Release"},{"key":"2026020103461267200_rbaf129-B65","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s42826-020-00057-x","article-title":"Brain factor-7(R) improves learning and memory deficits and attenuates ischemic brain damage by reduction of ROS generation in stroke in vivo and in vitro","volume":"36","author":"Noh","year":"2020","journal-title":"Lab Anim Res"},{"key":"2026020103461267200_rbaf129-B66","first-page":"181","article-title":"The effect of BF-7 on the ischemia-induced learning and memory deficits. Korean J anat. 2005 apr 38(2):181-188","volume":"38","author":"Lee","year":"2005","journal-title":"Korean J Anat"},{"key":"2026020103461267200_rbaf129-B67","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s11064-018-2691-8","article-title":"Effect of silk fibroin on neuroregeneration after traumatic brain injury","volume":"44","author":"Moisenovich","year":"2019","journal-title":"Neurochem Res"},{"key":"2026020103461267200_rbaf129-B68","doi-asserted-by":"crossref","first-page":"103307","DOI":"10.1016\/j.redox.2024.103307","article-title":"Unravelling the antioxidant behaviour of self-assembly beta-sheet in silk fibroin","volume":"76","author":"Qian","year":"2024","journal-title":"Redox Biol"},{"key":"2026020103461267200_rbaf129-B69","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2019.02.052","article-title":"Film interface for drug testing for delivery to cells in culture and in the brain","volume":"94","author":"Tang-Schomer","year":"2019","journal-title":"Acta Biomater"},{"key":"2026020103461267200_rbaf129-B70","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1016\/j.biomaterials.2011.04.032","article-title":"Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain","volume":"32","author":"Cooke","year":"2011","journal-title":"Biomaterials"},{"key":"2026020103461267200_rbaf129-B71","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1089\/ten.tea.2018.0215","article-title":"Local delivery of brain-derived neurotrophic factor enables behavioral recovery and tissue repair in Stroke-Injured rats","volume":"25","author":"Obermeyer","year":"2019","journal-title":"Tissue Eng Part A"},{"key":"2026020103461267200_rbaf129-B72","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3727\/096368908784423292","article-title":"Biocompatibility of PEG-based hydrogels in primate brain","volume":"17","author":"Bjugstad","year":"2008","journal-title":"Cell Transplant"},{"key":"2026020103461267200_rbaf129-B73","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bone.2006.09.006","article-title":"Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus","volume":"40","author":"Krampera","year":"2007","journal-title":"Bone"},{"key":"2026020103461267200_rbaf129-B74","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3389\/fnins.2017.00590","article-title":"The role of SDF-1\/CXCR4\/CXCR7 in neuronal regeneration after cerebral ischemia","volume":"11","author":"Cheng","year":"2017","journal-title":"Front Neurosci"},{"key":"2026020103461267200_rbaf129-B75","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00011-013-0699-8","article-title":"Intracranial injection of recombinant stromal-derived factor-1 alpha (SDF-1alpha) attenuates traumatic brain injury in rats","volume":"63","author":"Sun","year":"2014","journal-title":"Inflamm Res"},{"key":"2026020103461267200_rbaf129-B76","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.cell.2018.12.023","article-title":"A unique collateral artery development program promotes neonatal heart regeneration","volume":"176","author":"Das","year":"2019","journal-title":"Cell"},{"key":"2026020103461267200_rbaf129-B77","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1161\/STROKEAHA.111.618850","article-title":"Stroke treatment academic industry roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies","volume":"42","author":"Albers","year":"2011","journal-title":"Stroke"},{"key":"2026020103461267200_rbaf129-B78","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-017-1667-0","article-title":"Ischemic stroke: experimental models and reality","volume":"133","author":"Sommer","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2026020103461267200_rbaf129-B79","doi-asserted-by":"crossref","first-page":"e0153756","DOI":"10.1371\/journal.pone.0153756","article-title":"Precise characterization of the penumbra revealed by MRI: a modified photothrombotic stroke model study","volume":"11","author":"Qian","year":"2016","journal-title":"PLoS One"},{"key":"2026020103461267200_rbaf129-B80","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1111\/epi.17675","article-title":"Preclinical examination of early-onset thalamic-cortical seizures after hemispheric stroke","volume":"64","author":"Garcia-Pena","year":"2023","journal-title":"Epilepsia"},{"key":"2026020103461267200_rbaf129-B81","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1523\/JNEUROSCI.4147-07.2008","article-title":"Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats","volume":"28","author":"Weber","year":"2008","journal-title":"J Neurosci"},{"key":"2026020103461267200_rbaf129-B82","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/1073858409333076","article-title":"Remapping the somatosensory cortex after stroke: insight from imaging the synapse to network","volume":"15","author":"Winship","year":"2009","journal-title":"Neuroscientist"},{"key":"2026020103461267200_rbaf129-B83","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.3390\/ijms23137449","article-title":"Postischemic neuroprotection of aminoethoxydiphenyl borate associates shortening of Peri-Infarct depolarizations","volume":"23","author":"Fern\u00e1ndez-Serra","year":"2022","journal-title":"IJMS"},{"key":"2026020103461267200_rbaf129-B84","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neuroscience.2012.02.031","article-title":"Effects of stromal cell-derived factor 1alpha delivered at different phases of transient focal ischemia in rats","volume":"209","author":"Yoo","year":"2012","journal-title":"Neuroscience"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbaf129\/65857214\/rbaf129.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbaf129\/65857214\/rbaf129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbaf129\/65857214\/rbaf129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T08:46:29Z","timestamp":1769935589000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbaf129\/8378308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":84,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbaf129","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2025,12,12]]},"article-number":"rbaf129"}}