{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:19:21Z","timestamp":1790349561505,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272481"],"award-info":[{"award-number":["82272481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["323B2043"],"award-info":[{"award-number":["323B2043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2023YFB4605800"],"award-info":[{"award-number":["2023YFB4605800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The meniscus, a critical fibrocartilaginous structure in the knee joint that cushions load and stabilizes movement, suffers from poor self-healing potential following tears. This impaired repair not only fails to restore joint function but often progresses to osteoarthritis, posing significant clinical challenges. Regrettably, current therapeutic approaches, such as surgical suturing or partial resection, have limited efficacy in achieving functional regeneration of the meniscus. To address these bottlenecks, we developed a multifunctional composite hydrogel system integrating methacrylated silk fibroin (SilMA), cerium dioxide (CeO2) nanozymes and tetrahedral framework nucleic acid (tFNA)-miRNA-455. The SilMA hydrogel, leveraging photocrosslinking technology for on-demand solidification, offers injectability (enabling minimally invasive delivery), strong tissue adhesion and robust mechanical support\u2014effectively bridging meniscal tear gaps and creating a scaffold for cell infiltration. Embedded CeO2 nanozymes act as potent reactive oxygen species (ROS) scavengers and nanozyme-mediated ROS clearance mitigates inflammation and fosters a regeneration-conducive microenvironment. Moreover, tFNAs serve as a biocompatible, stable delivery vector for miRNA-455, protecting the nucleic acid from degradation and ensuring its efficient cellular uptake. This targeted delivery drives chondrogenic differentiation of synovial mesenchymal stem cells (SMSCs), directly promoting fibrocartilage formation. This synergistic strategy unites structural reinforcement, immunomodulation and stem cell regulation, overcoming conventional carrier limitations (cytotoxicity and poor stability) and demonstrating significant potential for meniscal repair. Ultimately, it offers a promising solution for cartilage regeneration and meniscus function restoration, with broad implications for clinical translation.<\/jats:p>","DOI":"10.1093\/rb\/rbag014","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:44:07Z","timestamp":1769777047000},"source":"Crossref","is-referenced-by-count":2,"title":["Silk fibroin hydrogel adhesive combined with miR-455 modified framework nucleic acids\/ROS-responsive CeO2 nanozymes for meniscus tears reconstruction"],"prefix":"10.1093","volume":"13","author":[{"given":"Chao","family":"Ning","sequence":"first","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"School of Medicine, Nankai University , Tianjin 300071,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Guizhou Medical University , Guiyang 550004, Guizhou,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"School of Medicine, Nankai University , Tianjin 300071,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Hebei Medical University Third Hospital, Department of Orthopedic Surgery, No.139 Ziqiang Road, Shijiazhuang 050051,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"School of Medicine, Nankai University , Tianjin 300071,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyang","family":"Long","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"School of Medicine, Nankai University , Tianjin 300071,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhao","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Guizhou Medical University , Guiyang 550004, Guizhou,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Sui","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"School of Medicine, Nankai University , Tianjin 300071,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu 610041,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-2227","authenticated-orcid":false,"given":"Quanyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital , Beijing 100048,","place":["People\u2019s Republic of China"]},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation , Beijing 100853,","place":["People\u2019s Republic of China"]},{"name":"School of Medicine, Nankai University , Tianjin 300071,","place":["People\u2019s Republic of China"]},{"name":"Guizhou Medical University , Guiyang 550004, Guizhou,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-6561","authenticated-orcid":false,"given":"Yunfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu 610041,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"2026032014064117700_rbag014-B1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41392-023-01670-7","article-title":"Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026032014064117700_rbag014-B2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41584-019-0255-1","article-title":"Surgical and tissue engineering strategies for articular cartilage and meniscus repair","volume":"15","author":"Kwon","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2026032014064117700_rbag014-B3","first-page":"14","article-title":"Dynamic-covalent hybrid hydrogels with cartilaginous immune microenvironment temporally regulating meniscus regeneration","volume":"50","author":"Chang","year":"2025","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B4","first-page":"61","article-title":"Advanced bioactive glue tethering lubricin\/PRG4 to promote integrated healing of avascular meniscus tears","volume":"28","author":"Tarafder","year":"2023","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B5","first-page":"2246","article-title":"Direct observation of gas meniscus formation on a superhydrophobic surface","volume":"13","author":"Eriksson","year":"2019","journal-title":"ACS Nano"},{"key":"2026032014064117700_rbag014-B6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/ard-2022-223227","article-title":"Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus","volume":"82","author":"Swahn","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"2026032014064117700_rbag014-B7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/bjsports-2023-107409","article-title":"Higher odds of meniscectomy compared with meniscus repair in a young patient population with increased neighbourhood disadvantage","volume":"58","author":"Dadoo","year":"2024","journal-title":"Br J Sports Med"},{"key":"2026032014064117700_rbag014-B8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2012.69","article-title":"Meniscus pathology, osteoarthritis and the treatment controversy","volume":"8","author":"Englund","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"2026032014064117700_rbag014-B9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.arthro.2022.12.002","article-title":"Treatment of degenerative meniscus tears","volume":"39","author":"Hohmann","year":"2023","journal-title":"Arthroscopy"},{"key":"2026032014064117700_rbag014-B10","doi-asserted-by":"crossref","first-page":"15281","DOI":"10.1021\/acsnano.4c13492","article-title":"Three-dimensional bioprinting of growth differentiation factor 5-preconditioned mesenchymal stem cell-derived exosomes facilitates articular cartilage endogenous regeneration","volume":"19","author":"Zheng","year":"2025","journal-title":"ACS Nano"},{"key":"2026032014064117700_rbag014-B11","first-page":"871","article-title":"Injectable ECM hydrogel for delivery of BMSCs enabled full-thickness meniscus repair in an orthotopic rat model","volume":"5","author":"Zhong","year":"2020","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B12","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.joca.2023.07.010","article-title":"Basic fibroblast growth factor promotes meniscus regeneration through the cultivation of synovial mesenchymal stem cells via the CXCL6\u2013CXCR2 pathway","volume":"31","author":"Goshima","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"2026032014064117700_rbag014-B13","first-page":"313","article-title":"3D-printed PCL scaffolds combined with injectable sodium alginate\/magnesium-doped mesoporous bioactive glass nanosphere hydrogel for meniscus regeneration: in vitro, in vivo, and multiomics-based therapeutic analyses","volume":"48","author":"Li","year":"2025","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s10787-023-01142-y","article-title":"Synovial mesenchymal stem cell-derived exosomal microRNA-320c facilitates cartilage damage repair by targeting ADAM19-dependent Wnt signalling in osteoarthritis rats","volume":"31","author":"Kong","year":"2023","journal-title":"Inflammopharmacology"},{"key":"2026032014064117700_rbag014-B15","doi-asserted-by":"crossref","first-page":"eabn8420","DOI":"10.1126\/sciadv.abn8420","article-title":"Articular fibrocartilage-targeted therapy by microtubule stabilization","volume":"8","author":"Li","year":"2022","journal-title":"Sci Adv"},{"key":"2026032014064117700_rbag014-B16","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/jor.24287","article-title":"Effect of dose and release rate of CTGF and TGF\u03b23 on avascular meniscus healing","volume":"37","author":"Tarafder","year":"2019","journal-title":"J Orthop Res"},{"key":"2026032014064117700_rbag014-B17","doi-asserted-by":"crossref","first-page":"e2414625","DOI":"10.1002\/advs.202414625","article-title":"MicroRNA gets a mighty award","volume":"12","author":"Li","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026032014064117700_rbag014-B18","first-page":"1132","article-title":"Profiles of exosomal microRNAs in joint cells and candidate microRNAs for cartilage regeneration","volume":"31","author":"Ganesh","year":"2025","journal-title":"Tissue Eng Part A"},{"key":"2026032014064117700_rbag014-B19","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1038\/s41467-021-24460-7","article-title":"Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2\u03b1 expression and coordinately regulate cartilage homeostasis","volume":"12","author":"Ito","year":"2021","journal-title":"Nat Commun"},{"key":"2026032014064117700_rbag014-B20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.joca.2015.10.018","article-title":"MicroRNAs: exploring new horizons in osteoarthritis","volume":"24","author":"Nugent","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"2026032014064117700_rbag014-B21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11926-016-0604-x","article-title":"The role of microRNAs and their targets in osteoarthritis","volume":"18","author":"Sondag","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"2026032014064117700_rbag014-B22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2019.10.007","article-title":"MicroRNA delivery through nanoparticles","volume":"313","author":"Lee","year":"2019","journal-title":"J Control Release"},{"key":"2026032014064117700_rbag014-B23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MOL.0b013e328350a425","article-title":"Lipid-based carriers of microRNAs and intercellular communication","volume":"23","author":"Vickers","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"2026032014064117700_rbag014-B24","doi-asserted-by":"crossref","first-page":"e2502661","DOI":"10.1002\/advs.202502661","article-title":"Cartilage-penetrating framework nucleic acid nanoparticles ameliorate osteoarthritis by promoting drug delivery and chondrocyte uptake","volume":"12","author":"Huang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026032014064117700_rbag014-B25","first-page":"634","article-title":"A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: application to endogenous regeneration of articular cartilage","volume":"40","author":"Fu","year":"2024","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B26","doi-asserted-by":"crossref","first-page":"121131","DOI":"10.1016\/j.biomaterials.2021.121131","article-title":"Chitosan hydrogel\/3D-printed poly(\u03b5-caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment","volume":"278","author":"Li","year":"2021","journal-title":"Biomaterials"},{"key":"2026032014064117700_rbag014-B27","doi-asserted-by":"crossref","first-page":"e2404626","DOI":"10.1002\/adhm.202404626","article-title":"Regional-specific decellularized meniscus extracellular matrix elastic nanofiber aerogels regulate meniscal regeneration and vascularization","volume":"14","author":"Huang","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"2026032014064117700_rbag014-B28","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1177\/0363546516639290","article-title":"Societal and economic effect of meniscus scaffold procedures for irreparable meniscus injuries","volume":"44","author":"Rongen","year":"2016","journal-title":"Am J Sports Med"},{"key":"2026032014064117700_rbag014-B29","doi-asserted-by":"crossref","first-page":"120466","DOI":"10.1016\/j.biomaterials.2020.120466","article-title":"3D cell-printing of biocompatible and functional meniscus constructs using meniscus-derived bioink","volume":"267","author":"Chae","year":"2021","journal-title":"Biomaterials"},{"key":"2026032014064117700_rbag014-B30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.joca.2013.11.002","article-title":"Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis","volume":"22","author":"Stone","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"2026032014064117700_rbag014-B31","first-page":"212","article-title":"Poly(p-coumaric acid) nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis","volume":"40","author":"Guo","year":"2024","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B32","first-page":"164","article-title":"Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis","volume":"32","author":"Yu","year":"2024","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B33","doi-asserted-by":"crossref","first-page":"eadf0988","DOI":"10.1126\/sciadv.adf0988","article-title":"Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis","volume":"9","author":"Chen","year":"2023","journal-title":"Sci Adv"},{"key":"2026032014064117700_rbag014-B34","doi-asserted-by":"crossref","first-page":"e2405069","DOI":"10.1002\/adhm.202405069","article-title":"Cerium dioxide nanoparticles-based inspector enhances mitochondrial quality control to maintain chondrocyte homeostasis in osteoarthritis therapy","volume":"14","author":"Chen","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"2026032014064117700_rbag014-B35","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41467-024-47029-6","article-title":"Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears","volume":"15","author":"Pan","year":"2024","journal-title":"Nat Commun"},{"key":"2026032014064117700_rbag014-B36","doi-asserted-by":"crossref","first-page":"155189","DOI":"10.1016\/j.cej.2024.155189","article-title":"A tetrahedral framework nucleic acids-based gene therapeutic nanococktail alleviates cartilage damage and protects against osteoarthritis progression","volume":"498","author":"Fu","year":"2024","journal-title":"Chem Eng J"},{"key":"2026032014064117700_rbag014-B37","doi-asserted-by":"crossref","first-page":"e2401452","DOI":"10.1002\/adhm.202401452","article-title":"Tetrahedral framework nucleic acid-based delivery of astaxanthin suppresses chondrocyte pyroptosis and modulates oxidative stress for the treatment of osteoarthritis","volume":"13","author":"Li","year":"2024","journal-title":"Adv Healthc Mater."},{"key":"2026032014064117700_rbag014-B38","first-page":"358","article-title":"Functional meniscus reconstruction with biological and biomechanical heterogeneities through topological self-induction of stem cells","volume":"36","author":"Du","year":"2024","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B39","doi-asserted-by":"crossref","first-page":"123195","DOI":"10.1016\/j.biomaterials.2025.123195","article-title":"Cascade targeting selenium nanoparticles-loaded hydrogel microspheres for multifaceted antioxidant defense in osteoarthritis","volume":"318","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"2026032014064117700_rbag014-B40","doi-asserted-by":"crossref","first-page":"e2414419","DOI":"10.1002\/advs.202414419","article-title":"Rejuvenating hyaline cartilage with senescence-targeting Si-ADAM19 delivery for osteoarthritis therapy","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026032014064117700_rbag014-B41","first-page":"242","article-title":"Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments","volume":"32","author":"Xiao","year":"2024","journal-title":"Bioact Mater"},{"key":"2026032014064117700_rbag014-B42","doi-asserted-by":"crossref","first-page":"152132","DOI":"10.1016\/j.cej.2024.152132","article-title":"Curcumin-loaded biomimetic nanosponges for osteoarthritis alleviation by synergistically suppressing inflammation and ferroptosis","volume":"491","author":"Xu","year":"2024","journal-title":"Chem Eng J"},{"key":"2026032014064117700_rbag014-B43","doi-asserted-by":"crossref","first-page":"110670","DOI":"10.1016\/j.matdes.2022.110670","article-title":"An injectable and photocurable methacrylate-silk fibroin hydrogel loaded with bFGF for spinal cord regeneration","volume":"217","author":"Zhou","year":"2022","journal-title":"Mater Des"},{"key":"2026032014064117700_rbag014-B44","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1039\/D1BM00535A","article-title":"3D bio-printed biphasic scaffolds with dual modification of silk fibroin for the integrated repair of osteochondral defects","volume":"9","author":"Deng","year":"2021","journal-title":"Biomater Sci"},{"key":"2026032014064117700_rbag014-B45","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1038\/s41467-025-61842-7","article-title":"CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis","volume":"16","author":"Sun","year":"2025","journal-title":"Nat Commun"},{"key":"2026032014064117700_rbag014-B46","doi-asserted-by":"crossref","first-page":"e03807","DOI":"10.1002\/advs.202503807","article-title":"Symmetry breaking in meniscus splitting: effects of boundary conditions and polymeric membrane growth","volume":"12","author":"Nguyen","year":"2025","journal-title":"Adv Sci (Weinh)"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag014\/66792467\/rbag014.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag014\/66792467\/rbag014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag014\/66792467\/rbag014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:06:55Z","timestamp":1774030015000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag014\/8466022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":46,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag014","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag014"}}