{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:57:09Z","timestamp":1790045829909,"version":"4.0.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":86,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiyuan\u2019s \u2018Open bidding for selecting the best candidates\u2019 Program","award":["2024TYJB0149"],"award-info":[{"award-number":["2024TYJB0149"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ovarian aging is characterized by depletion of the follicular reserve. The extracellular matrix (ECM) provides the essential microenvironmental niche for follicles, and aged-related alterations in ECM composition may adversely affect follicular dynamics. However, the precise relationship between matrix components and ovarian aging remains unclear. In this study, we first observed a marked reduction in type III collagen (Col III) as a key alteration associated with ovarian aging. Furthermore, we discovered that as a biomaterial, recombinant humanized type III collagen (rhCol III) ameliorated ovarian function in 12-month-old natural aging rats, evidenced by restored estrous cycles, increased ovarian index, elevated levels of anti-M\u00fcllerian hormone (AMH) and estradiol (E2) and enhanced folliculogenesis. Notably, rhCol III promoted the reorganization of the disorganized ovarian ECM into a highly ordered and dense structure, providing a supportive biological scaffold for follicular development. Additionally, supplementation of rhCol III could mitigate oxidative stress and mitochondrial dysfunction in aged granulosa cells (GCs), thereby preventing apoptosis and cellular senescence. Mechanistically, rhCol III bound to the integrin \u03b12 (ITGA2) receptor on GCs and activated the PI3K\/Akt signaling pathway. Our findings highlight Col III deficiency as a critical factor in ovarian aging and demonstrate that rhCol III supplementation rejuvenates the ovarian microenvironment via the ITGA2-PI3K\/Akt axis, presenting a novel therapeutic strategy. Thus ITGA2 may represent a promising target for mitigating ovarian aging.<\/jats:p>","DOI":"10.1093\/rb\/rbag046","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:43:59Z","timestamp":1774442639000},"source":"Crossref","is-referenced-by-count":1,"title":["Recombinant humanized type III collagen improves ovarian function via ITGA2-mediated mitochondrial function restoration in granulosa cells and extracellular matrix remodeling"],"prefix":"10.1093","volume":"13","author":[{"given":"Quan","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0064-8440","authenticated-orcid":false,"given":"Shuang","family":"You","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Chengdu Women and Children\u2019s Central Hospital, University of Electronic Science and Technology of China , Chengdu, Sichuan 610091,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"He","sequence":"additional","affiliation":[{"name":"The Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]},{"name":"Joint International Research Lab for Reproduction and Development, Ministry of Education , Chongqing 400010,","place":["China"]},{"name":"Reproduction and Stem Cell Therapy Research Center of Chongqing , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Functional Proteins, Shanxi Jinbo Bio-Pharmaceutical Co., Ltd , Taiyuan, Shanxi 030032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-2631","authenticated-orcid":false,"given":"Lina","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010,","place":["China"]},{"name":"Joint International Research Lab for Reproduction and Development, Ministry of Education , Chongqing 400010,","place":["China"]},{"name":"Reproduction and Stem Cell Therapy Research Center of Chongqing , Chongqing 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"2026052507120061600_rbag046-B1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1515\/mr-2022-0031","article-title":"Ovarian aging: mechanisms and intervention strategies","volume":"2","author":"Zhu","year":"2022","journal-title":"Med Rev (2021)"},{"key":"2026052507120061600_rbag046-B2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tem.2025.01.005","article-title":"Hallmarks of ovarian aging","volume":"36","author":"Wu","year":"2025","journal-title":"Trends Endocrinol Metab"},{"key":"2026052507120061600_rbag046-B3","first-page":"e500","article-title":"No-271-delayed child-bearing","volume":"39","author":"Johnson","year":"2017","journal-title":"JOGC"},{"key":"2026052507120061600_rbag046-B4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrendo.2015.167","article-title":"Molecular insights into the aetiology of female reproductive ageing","volume":"11","author":"Perry","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"2026052507120061600_rbag046-B5","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s10815-022-02579-w","article-title":"Biomechanical characteristics of the ovarian cortex in POI patients and functional outcomes after drug-free IVA","volume":"39","author":"M\u00e9ndez","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"2026052507120061600_rbag046-B6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/humrep\/dead008","article-title":"Spatio-temporal remodelling of the composition and architecture of the human ovarian cortical extracellular matrix duringin vitroculture","volume":"38","author":"Grosbois","year":"2023","journal-title":"Hum Reprod"},{"key":"2026052507120061600_rbag046-B7","doi-asserted-by":"crossref","first-page":"e13259","DOI":"10.1111\/acel.13259","article-title":"Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices","volume":"19","author":"Amargant","year":"2020","journal-title":"Aging Cell"},{"key":"2026052507120061600_rbag046-B8","doi-asserted-by":"crossref","first-page":"a004978","DOI":"10.1101\/cshperspect.a004978","article-title":"The collagen family","volume":"3","author":"Ricard-Blum","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026052507120061600_rbag046-B9","doi-asserted-by":"crossref","first-page":"C1017","DOI":"10.1152\/ajpcell.00287.2023","article-title":"Alignment, cross linking, and beyond: a collagen architect\u2019s guide to the skeletal muscle extracellular matrix","volume":"325","author":"Wohlgemuth","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026052507120061600_rbag046-B10","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801651","article-title":"The collagen suprafamily: from biosynthesis to advanced biomaterial development","volume":"31","author":"Sorushanova","year":"2019","journal-title":"Adv Mater"},{"key":"2026052507120061600_rbag046-B11","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1080\/00016340601033741","article-title":"Collagens in the human ovary and their changes in the perifollicular stroma during ovulation","volume":"85","author":"Lind","year":"2006","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2026052507120061600_rbag046-B12","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/humrep\/deaa100","article-title":"E. Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause","volume":"35","author":"Amorim","year":"2020","journal-title":"Hum Reprod"},{"key":"2026052507120061600_rbag046-B13","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1210\/en.2004-1440","article-title":"Differential expression of procollagen lysine 2-oxoglutarate 5-deoxygenase and matrix metalloproteinase isoforms in hypothyroid rat ovary and disintegration of extracellular matrix","volume":"146","author":"Roy","year":"2005","journal-title":"Endocrinology"},{"key":"2026052507120061600_rbag046-B14","doi-asserted-by":"crossref","first-page":"065009","DOI":"10.1088\/1748-6041\/11\/6\/065009","article-title":"The effect of collagen hydrogel on 3D culture of ovarian follicles","volume":"11","author":"Joo","year":"2016","journal-title":"Biomed Mater"},{"key":"2026052507120061600_rbag046-B15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s11626-019-00337-4","article-title":"Transplantation of umbilical cord-derived mesenchymal stem cells on a collagen scaffold improves ovarian function in a premature ovarian failure model of mice","volume":"55","author":"Yang","year":"2019","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"2026052507120061600_rbag046-B16","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.bbrc.2018.12.018","article-title":"Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity","volume":"508","author":"Hua","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"2026052507120061600_rbag046-B17","doi-asserted-by":"crossref","DOI":"10.1186\/s42825-022-00103-5","article-title":"Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype","volume":"4","author":"Wang","year":"2022","journal-title":"J Leather Sci Eng"},{"key":"2026052507120061600_rbag046-B18","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1021\/acsbiomaterials.9b01649","article-title":"Intravaginal administration of human type III collagen-derived biomaterial with high cell-adhesion activity to treat vaginal atrophy in rats","volume":"6","author":"You","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"2026052507120061600_rbag046-B19","doi-asserted-by":"crossref","first-page":"rbad033","DOI":"10.1093\/rb\/rbad033","article-title":"Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation","volume":"10","author":"You","year":"2023","journal-title":"Regen Biomater"},{"key":"2026052507120061600_rbag046-B20","doi-asserted-by":"crossref","first-page":"133994","DOI":"10.1016\/j.ijbiomac.2024.133994","article-title":"Recombinant humanized type I collagen remodels decidual immune microenvironment at maternal-fetal interface by modulating Th17\/treg imbalance","volume":"276","author":"Wang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"2026052507120061600_rbag046-B21","doi-asserted-by":"crossref","first-page":"110030","DOI":"10.1016\/j.cellsig.2021.110030","article-title":"PCOS follicular fluid derived exosomal miR-424-5p induces granulosa cells senescence by targeting CDCA4 expression","volume":"85","author":"Yuan","year":"2021","journal-title":"Cell Signal"},{"key":"2026052507120061600_rbag046-B22","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1080\/15384101.2019.1624108","article-title":"Morphological changes during replicative senescence in bovine ovarian granulosa cells","volume":"18","author":"Son","year":"2019","journal-title":"Cell Cycle"},{"key":"2026052507120061600_rbag046-B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2019.08.029","article-title":"Estradiol treatment improves biological rhythms in a preclinical rat model of menopause","volume":"83","author":"Yin","year":"2019","journal-title":"Neurobiol Aging"},{"key":"2026052507120061600_rbag046-B24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1042\/CS20255841","article-title":"Impact of the natural female reproductive aging on the rat serum lipidome","volume":"139","author":"Baudin","year":"2025","journal-title":"Clin Sci (Lond)"},{"key":"2026052507120061600_rbag046-B25","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1177\/1933719117741376","article-title":"The impact of a long-acting oral sphingosine-1-phosphate analogue on ovarian aging in a rat model","volume":"25","author":"Mumusoglu","year":"2018","journal-title":"Reprod Sci"},{"key":"2026052507120061600_rbag046-B26","doi-asserted-by":"crossref","first-page":"153752","DOI":"10.1016\/j.phymed.2021.153752","article-title":"Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia","volume":"92","author":"Chen","year":"2021","journal-title":"Phytomedicine"},{"key":"2026052507120061600_rbag046-B27","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41467-022-28611-2","article-title":"TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice","volume":"13","author":"Qin","year":"2022","journal-title":"Nat Commun"},{"key":"2026052507120061600_rbag046-B28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13287-022-03012-w","article-title":"Cell-free fat extract improves ovarian function and fertility in mice with premature ovarian insufficiency","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"2026052507120061600_rbag046-B29","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nrclinonc.2011.110","article-title":"Hormone replacement therapy and the risk of breast cancer","volume":"8","author":"Narod","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"2026052507120061600_rbag046-B30","doi-asserted-by":"crossref","first-page":"101577","DOI":"10.1016\/j.beem.2021.101577","article-title":"Menopausal hormone therapy and breast cancer risk","volume":"35","author":"Rozenberg","year":"2021","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026052507120061600_rbag046-B31","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/s12951-022-01566-8","article-title":"Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging","volume":"20","author":"Wu","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"2026052507120061600_rbag046-B32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12964-024-01616-8","article-title":"GDF9His209GlnfsTer6\/S428T and GDF9Q321X\/S428T bi-allelic variants caused female subfertility with defective follicle enlargement","volume":"22","author":"Duan","year":"2024","journal-title":"Cell Commun Signal"},{"key":"2026052507120061600_rbag046-B33","doi-asserted-by":"crossref","first-page":"e14031","DOI":"10.1111\/acel.14031","article-title":"SIRT6 deficiency causes ovarian hypoplasia by affecting Plod1-related collagen formation","volume":"23","author":"Li","year":"2024","journal-title":"Aging Cell"},{"key":"2026052507120061600_rbag046-B34","first-page":"292","article-title":"Extracellular matrix-templating fibrous hydrogels promote ovarian tissue remodeling and oocyte growth","volume":"32","author":"Nason-Tomaszewski","year":"2024","journal-title":"Bioact Mater"},{"key":"2026052507120061600_rbag046-B35","doi-asserted-by":"crossref","first-page":"108029","DOI":"10.1016\/j.anireprosci.2025.108029","article-title":"Characteristics of collagen in ovarian extracellular matrix and its relationship with the development of primordial follicles up to ovulation","volume":"283","author":"F\u00e9lix","year":"2025","journal-title":"Anim Reprod Sci"},{"key":"2026052507120061600_rbag046-B36","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00418-006-0194-1","article-title":"Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis","volume":"126","author":"Berkholtz","year":"2006","journal-title":"Histochem Cell Biol"},{"key":"2026052507120061600_rbag046-B37","doi-asserted-by":"crossref","first-page":"15591","DOI":"10.1096\/fj.202001377R","article-title":"The p38 signaling pathway mediates the TGF-\u03b21-induced increase in type I collagen deposition in human granulosa cells","volume":"34","author":"Li","year":"2020","journal-title":"FASEB J"},{"key":"2026052507120061600_rbag046-B38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ydbio.2016.05.022","article-title":"Novel action of FOXL2 as mediator of Col1a2 gene autoregulation","volume":"416","author":"Marongiu","year":"2016","journal-title":"Dev Biol"},{"key":"2026052507120061600_rbag046-B39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.rbmo.2021.02.012","article-title":"Basal lamina characterization in frozen-thawed and long-term grafted human prepubertal ovarian tissue","volume":"42","author":"Philippart","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"2026052507120061600_rbag046-B40","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1111\/j.1582-4934.2009.00841.x","article-title":"Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue","volume":"14","author":"Papachroni","year":"2010","journal-title":"J Cell Mol Med"},{"key":"2026052507120061600_rbag046-B41","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.fertnstert.2006.06.022","article-title":"Increased type III and V collagen expression in human corpora lutea in early pregnancy","volume":"87","author":"Iwahashi","year":"2007","journal-title":"Fertil Steril"},{"key":"2026052507120061600_rbag046-B42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13048-021-00769-1","article-title":"Lnc-GULP1\u20132:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization","volume":"14","author":"Yao","year":"2021","journal-title":"J Ovarian Res"},{"key":"2026052507120061600_rbag046-B43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11154-007-9032-6","article-title":"Metastin\/kisspeptin and control of estrous cycle in rats","volume":"8","author":"Maeda","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"key":"2026052507120061600_rbag046-B44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.regpep.2004.04.021","article-title":"Effect of PACAP on LH release studied by cell immunoblot assay depends on the gender, on the time of day and in female rats on the day of the estrous cycle","volume":"123","author":"Szab\u00f3","year":"2004","journal-title":"Regul Pept"},{"key":"2026052507120061600_rbag046-B45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/10408347.2019.1623010","article-title":"Advancements in the analytical quantification of nitroxidative stress biomarker 3-nitrotyrosine in biological matrices","volume":"50","author":"Bandookwala","year":"2020","journal-title":"Crit Rev Anal Chem"},{"key":"2026052507120061600_rbag046-B46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13048-023-01300-4","article-title":"The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities","volume":"16","author":"Shen","year":"2023","journal-title":"J Ovarian Res"},{"key":"2026052507120061600_rbag046-B47","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/s41467-021-25934-4","article-title":"A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis","volume":"12","author":"Ouni","year":"2021","journal-title":"Nat Commun"},{"key":"2026052507120061600_rbag046-B48","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.2147\/IJN.S533393","article-title":"Primed extracellular vesicles as a nanotherapeutic strategy to enhance granulosa cell function in a model of premature ovarian insufficiency and hormonal decline","volume":"20","author":"Shieh","year":"2025","journal-title":"Int J Nanomedicine"},{"key":"2026052507120061600_rbag046-B49","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.3390\/ijms24119205","article-title":"Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review","volume":"24","author":"Liu","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026052507120061600_rbag046-B50","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/humupd\/dmw028","article-title":"Ovarian ageing: the role of mitochondria in oocytes and follicles","volume":"22","author":"May-Panloup","year":"2016","journal-title":"Hum Reprod Update"},{"key":"2026052507120061600_rbag046-B51","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/humrep\/dead177","article-title":"Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction","volume":"38","author":"Smits","year":"2023","journal-title":"Hum Reprod"},{"key":"2026052507120061600_rbag046-B52","doi-asserted-by":"crossref","first-page":"102684","DOI":"10.1016\/j.redox.2023.102684","article-title":"miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation","volume":"62","author":"Wang","year":"2023","journal-title":"Redox Biol"},{"key":"2026052507120061600_rbag046-B53","article-title":"HIGD1A alleviates oxidative stress related ovarian hypofunction by enhancing granulosa cell functions via NF-\u03baB\/SOD2 signaling pathway","volume":"12","author":"Li","year":"2025","journal-title":"Advanced Science"},{"key":"2026052507120061600_rbag046-B54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41556-018-0223-z","article-title":"Integrin trafficking in cells and tissues","volume":"21","author":"Moreno-Layseca","year":"2019","journal-title":"Nat Cell Biol"},{"key":"2026052507120061600_rbag046-B55","doi-asserted-by":"crossref","first-page":"e2406865","DOI":"10.1002\/advs.202406865","article-title":"Integrin \u03b28 facilitates macrophage infiltration and polarization by regulating CCL5 to promote LUAD progression","volume":"12","author":"Song","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026052507120061600_rbag046-B56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tcb.2019.01.001","article-title":"Class II PI3K functions in cell biology and disease","volume":"29","author":"Gulluni","year":"2019","journal-title":"Trends Cell Biol"},{"key":"2026052507120061600_rbag046-B57","doi-asserted-by":"crossref","first-page":"155382","DOI":"10.1016\/j.phymed.2024.155382","article-title":"Artesunate improves glucose and lipid metabolism in db\/db mice by regulating the metabolic profile and the MAPK\/PI3K\/akt signalling pathway","volume":"126","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"2026052507120061600_rbag046-B58","doi-asserted-by":"crossref","first-page":"1041583","DOI":"10.1155\/2019\/1041583","article-title":"Integrated analysis of miRNA-mRNA interaction network in porcine granulosa cells undergoing oxidative stress","volume":"2019","author":"Du","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"2026052507120061600_rbag046-B59","first-page":"839","article-title":"Joint transcriptome and metabolome analysis prevails the biological mechanisms underlying the pro-survival fight in in vitro heat-stressed granulosa cells","volume":"11","author":"Sammad","year":"2022","journal-title":"Biology (Basel)"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag046\/67631370\/rbag046.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag046\/67631370\/rbag046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag046\/67631370\/rbag046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:12:13Z","timestamp":1779707533000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag046\/8554169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":59,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag046","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag046"}}