{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:46:13Z","timestamp":1790192773880,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272290"],"award-info":[{"award-number":["82272290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22474079"],"award-info":[{"award-number":["22474079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012677"],"award-info":[{"award-number":["2024A1515012677"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Research Program of Shenzhen","award":["JCYJ20240813142810014"],"award-info":[{"award-number":["JCYJ20240813142810014"]}]},{"name":"Shenzhen University 2035 Program for Excellent Research","award":["2024C004"],"award-info":[{"award-number":["2024C004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The escalating global prevalence of obesity and its associated metabolic disorders now represents one of the most urgent public health crises. Despite the pressing need for safe and effective anti-obesity interventions, current therapeutic options are often limited by suboptimal efficacy and various side effects. Herein, we present a microneedle (MN)-based drug delivery platform, termed RES@hmPDA-Dpep\/MN, for photothermal browning therapy (PBT) to combat obesity. This system integrates hemispherical mesoporous polydopamine (hmPDA) nanoparticles with resveratrol (RES) and an adipose-homing peptide (Dpep) for localized PBT. Under identical conditions, hmPDA maintains photothermal performance comparable to spherical mPDA, while exhibiting advantageous drug-loading behavior, particularly under higher drug-feeding conditions. In addition, the platform supports localized delivery with near-infrared-triggered, on-demand RES release and thermogenic activation. In vivo studies demonstrate that the RES@hmPDA-Dpep\/MN system effectively suppresses white adipose tissue expansion, reduces body weight by 16.1 \u00b1 2.5%, and significantly improves obesity-associated metabolic dysfunctions, including hyperlipidemia and hepatic steatosis. Mechanistic analyses reveal marked upregulation of uncoupling protein 1 (UCP1) and other key browning genes. Furthermore, the nanoplatform shows favorable in vitro biocompatibility and hemocompatibility, supporting its potential for further translational evaluation. Collectively, this PBT strategy may serve as a potential localized intervention for fat reduction and systemic metabolic improvement in the management of obesity and related metabolic disorders.<\/jats:p>","DOI":"10.1093\/rb\/rbag052","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:44:39Z","timestamp":1772801079000},"source":"Crossref","is-referenced-by-count":2,"title":["NIR-activated adipose-targeted nanocarrier drives local browning and metabolic restoration"],"prefix":"10.1093","volume":"13","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enze","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenghua Zizhu Academy , Shanghai 200241,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, Faculty of Medical Science, University College London , London NW3 2PP,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayingzi","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Medical School, Shenzhen University , Shenzhen 518055,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2026050914114949000_rbag052-B1","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1001\/jama.2018.5158","article-title":"Differences in obesity prevalence by demographics and urbanization in US children and adolescents, 2013-2016","volume":"319","author":"Ogden","year":"2018","journal-title":"Jama"},{"key":"2026050914114949000_rbag052-B2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2024","journal-title":"Lancet"},{"key":"2026050914114949000_rbag052-B3","doi-asserted-by":"crossref","first-page":"e1166","DOI":"10.1016\/S2214-109X(19)30276-1","article-title":"Prevention and control of obesity in China","volume":"7","author":"Wang","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2026050914114949000_rbag052-B4","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/s41591-024-03095-3","article-title":"A new framework for the diagnosis, staging and management of obesity in adults","volume":"30","author":"Busetto","year":"2024","journal-title":"Nat Med"},{"key":"2026050914114949000_rbag052-B5","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0140-6736(22)02403-5","article-title":"Contemporary medical, device, and surgical therapies for obesity in adults","volume":"401","author":"Perdomo","year":"2023","journal-title":"Lancet"},{"key":"2026050914114949000_rbag052-B6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.tvir.2013.08.002","article-title":"Tumor ablation: common modalities and general practices","volume":"16","author":"Knavel","year":"2013","journal-title":"Tech Vasc Interv Radiol"},{"key":"2026050914114949000_rbag052-B7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"2026050914114949000_rbag052-B8","doi-asserted-by":"crossref","first-page":"e2207686","DOI":"10.1002\/adma.202207686","article-title":"Gold nanobipyramid-mediated apoptotic camouflage of adipocytes for obesity immunotherapy","volume":"35","author":"Yan","year":"2023","journal-title":"Adv Mater"},{"key":"2026050914114949000_rbag052-B9","first-page":"9816594","article-title":"Low-temperature photothermal therapy: strategies and applications","volume":"2021","author":"Yi","year":"2021","journal-title":"Research (Wash D C)"},{"key":"2026050914114949000_rbag052-B10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.addr.2020.01.003","article-title":"Molecular and biological rationale of hyperthermia as radio- and chemosensitizer","volume":"163-164","author":"Oei","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"2026050914114949000_rbag052-B11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","article-title":"The cellular and functional complexity of thermogenic fat","volume":"22","author":"Cohen","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026050914114949000_rbag052-B12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and Beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab"},{"key":"2026050914114949000_rbag052-B13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cmet.2014.07.005","article-title":"The browning of white adipose tissue: some burning issues","volume":"20","author":"Nedergaard","year":"2014","journal-title":"Cell Metab"},{"key":"2026050914114949000_rbag052-B14","article-title":"Adipocyte-targeted nanocomplex with synergistic photothermal and pharmacological effects for combating obesity and related metabolic syndromes","volume":"14","author":"Zhang","year":"2024","journal-title":"Nanomaterials (Basel)"},{"key":"2026050914114949000_rbag052-B15","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1021\/acsnano.1c06410","article-title":"Transdermal photothermal-pharmacotherapy to remodel adipose tissue for obesity and metabolic disorders","volume":"16","author":"Zan","year":"2022","journal-title":"ACS Nano"},{"key":"2026050914114949000_rbag052-B16","doi-asserted-by":"crossref","first-page":"e2406985","DOI":"10.1002\/advs.202406985","article-title":"Two-pronged attack: dual activation of fat reduction using near-infrared-responsive nanosandwich for targeted anti-obesity treatment","volume":"11","author":"Xiao","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026050914114949000_rbag052-B17","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.cell.2022.02.004","article-title":"Local hyperthermia therapy induces browning of white fat and treats obesity","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"key":"2026050914114949000_rbag052-B18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/biof.1164","article-title":"Nutraceuticals and regulation of adipocyte life: premises or promises","volume":"40","author":"Colitti","year":"2014","journal-title":"Biofactors"},{"key":"2026050914114949000_rbag052-B19","doi-asserted-by":"crossref","first-page":"104411","DOI":"10.1016\/j.phrs.2019.104411","article-title":"Effect of resveratrol on adipokines and myokines involved in fat browning: perspectives in healthy weight against obesity","volume":"148","author":"Kim","year":"2019","journal-title":"Pharmacol Res"},{"key":"2026050914114949000_rbag052-B20","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1080\/10408398.2022.2159921","article-title":"Resveratrol in disease prevention and health promotion: a role of the gut microbiome","volume":"64","author":"Chen","year":"2024","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2026050914114949000_rbag052-B21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.29238","article-title":"SIRT1\/HSF1\/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress","volume":"66","author":"Zheng","year":"2017","journal-title":"Hepatology"},{"key":"2026050914114949000_rbag052-B22","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1021\/acs.jafc.7b00418","article-title":"Resveratrol reactivates latent HIV through increasing histone acetylation and activating heat shock factor 1","volume":"65","author":"Zeng","year":"2017","journal-title":"J Agric Food Chem"},{"key":"2026050914114949000_rbag052-B23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12951-019-0554-3","article-title":"Nanotechnology advances towards development of targeted-treatment for obesity","volume":"17","author":"Sibuyi","year":"2019","journal-title":"J Nanobiotechnology"},{"key":"2026050914114949000_rbag052-B24","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nmat4092","article-title":"Oligopeptide complex for targeted non-viral gene delivery to adipocytes","volume":"13","author":"Won","year":"2014","journal-title":"Nat Mater"},{"key":"2026050914114949000_rbag052-B25","doi-asserted-by":"crossref","first-page":"026101","DOI":"10.1063\/5.0088447","article-title":"Use of mesoporous polydopamine nanoparticles as a stable drug-release system alleviates inflammation in knee osteoarthritis","volume":"6","author":"Wang","year":"2022","journal-title":"APL Bioeng"},{"key":"2026050914114949000_rbag052-B26","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nm.4429","article-title":"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis","volume":"23","author":"Ikeda","year":"2017","journal-title":"Nat Med"},{"key":"2026050914114949000_rbag052-B27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tips.2008.08.003","article-title":"Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1","volume":"29","author":"Gavva","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"2026050914114949000_rbag052-B28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tips.2007.10.016","article-title":"The emerging role of TRPV1 in diabetes and obesity","volume":"29","author":"Suri","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"2026050914114949000_rbag052-B29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-022-05067-4","article-title":"Post-translational control of beige fat biogenesis by PRDM16 stabilization","volume":"609","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"2026050914114949000_rbag052-B30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"2026050914114949000_rbag052-B31","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1021\/jacs.9b02091","article-title":"Versatile nanoemulsion assembly approach to synthesize functional mesoporous carbon nanospheres with tunable pore sizes and architectures","volume":"141","author":"Peng","year":"2019","journal-title":"J Am Chem Soc"},{"key":"2026050914114949000_rbag052-B32","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1021\/acsnano.1c01146","article-title":"Janus nanoparticles: from fabrication to (bio)applications","volume":"15","author":"Zhang","year":"2021","journal-title":"ACS Nano"},{"key":"2026050914114949000_rbag052-B33","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41557-023-01183-4","article-title":"Emulsion-oriented assembly for janus double-spherical mesoporous nanoparticles as biological logic gates","volume":"15","author":"Zhao","year":"2023","journal-title":"Nat Chem"},{"key":"2026050914114949000_rbag052-B34","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s40843-025-3311-6","article-title":"Mesoporous bowl-shaped polydopamine co-loaded temozolomide and indocyanine green for synergistically inhibiting glioblastoma","volume":"68","author":"Zheng","year":"2025","journal-title":"Science China-Materials"},{"key":"2026050914114949000_rbag052-B35","doi-asserted-by":"crossref","first-page":"rbad031","DOI":"10.1093\/rb\/rbad031","article-title":"Polydopamine nanoparticle-mediated mild photothermal therapy for inhibiting atherosclerotic plaque progression by regulating lipid metabolism of foam cells","volume":"10","author":"Tu","year":"2023","journal-title":"Regen Biomater"},{"key":"2026050914114949000_rbag052-B36","doi-asserted-by":"crossref","first-page":"rbae073","DOI":"10.1093\/rb\/rbae073","article-title":"The therapeutic efficacy of different configuration nano-polydopamine drug carrier systems with photothermal synergy against head and neck squamous cell carcinoma","volume":"11","author":"Guo","year":"2024","journal-title":"Regen Biomater"},{"key":"2026050914114949000_rbag052-B37","first-page":"4185","article-title":"Application of poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery","volume":"7","author":"Wang","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"2026050914114949000_rbag052-B38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11095-017-2340-y","article-title":"Optimization of weight ratio for DSPE-PEG\/TPGS hybrid micelles to improve drug retention and tumor penetration","volume":"35","author":"Jin","year":"2018","journal-title":"Pharm Res"},{"key":"2026050914114949000_rbag052-B39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.actbio.2024.04.029","article-title":"Adipocyte-targeted delivery of rosiglitazone with localized photothermal therapy for the treatment of diet-induced obesity in mice","volume":"181","author":"Zhang","year":"2024","journal-title":"Acta Biomater"},{"key":"2026050914114949000_rbag052-B40","doi-asserted-by":"crossref","first-page":"106758","DOI":"10.1016\/j.jff.2025.106758","article-title":"Eriocitrin promotes browning of white adipose tissue and activates brown adipose tissue through regulating HSF1\/PGC-1\u03b1 pathways","volume":"127","author":"Chen","year":"2025","journal-title":"J Funct Foods"},{"key":"2026050914114949000_rbag052-B41","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/s41589-025-01966-5","article-title":"Mechanism of capsaicin entry into buried vanilloid sites in TRPV1","volume":"21","author":"Sun","year":"2025","journal-title":"Nat Chem Biol"},{"key":"2026050914114949000_rbag052-B42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/chemse\/bju057","article-title":"Auto-oxidation products of epigallocatechin gallate activate TRPA1 and TRPV1 in sensory neurons","volume":"40","author":"Kurogi","year":"2015","journal-title":"Chem Senses"},{"key":"2026050914114949000_rbag052-B43","doi-asserted-by":"crossref","first-page":"108938","DOI":"10.1016\/j.abb.2021.108938","article-title":"Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells","volume":"707","author":"Guo","year":"2021","journal-title":"Arch Biochem Biophys"},{"key":"2026050914114949000_rbag052-B44","doi-asserted-by":"crossref","first-page":"rbaf092","DOI":"10.1093\/rb\/rbaf092","article-title":"L-arginine-loaded microneedle patch enhances diabetic wound healing by regulating macrophage polarisation and mitochondrial homeostasis","volume":"12","author":"Wang","year":"2025","journal-title":"Regen Biomater"},{"key":"2026050914114949000_rbag052-B45","doi-asserted-by":"crossref","first-page":"94908541","DOI":"10.26599\/NR.2026.94908541","article-title":"Lymphatic remodeling and metabolic rescue by VEGFR-3\/DHA-coordinated microneedles for hair regeneration","volume":"19","author":"Liu","year":"2026","journal-title":"Nano Res"},{"key":"2026050914114949000_rbag052-B46","doi-asserted-by":"crossref","first-page":"122687","DOI":"10.1016\/j.biomaterials.2024.122687","article-title":"A quick paster type of soluble nanoparticle microneedle patch for the treatment of obesity","volume":"311","author":"Chen","year":"2024","journal-title":"Biomaterials"},{"key":"2026050914114949000_rbag052-B47","doi-asserted-by":"crossref","first-page":"11792","DOI":"10.1021\/acsnano.4c13609","article-title":"Effervescent microneedles for the codelivery of chitosan nanoparticles and indocyanine green to enhance the treatment of diet-induced obesity in mice","volume":"19","author":"Luo","year":"2025","journal-title":"ACS Nano"},{"key":"2026050914114949000_rbag052-B48","doi-asserted-by":"crossref","first-page":"e2300822","DOI":"10.1002\/advs.202300822","article-title":"Layer-specific BTX-A delivery to the gastric muscularis achieves effective weight control and metabolic improvement","volume":"10","author":"Wang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2026050914114949000_rbag052-B49","doi-asserted-by":"crossref","first-page":"9223","DOI":"10.1021\/acsnano.7b04348","article-title":"Locally induced adipose tissue browning by microneedle patch for obesity treatment","volume":"11","author":"Zhang","year":"2017","journal-title":"ACS Nano"},{"key":"2026050914114949000_rbag052-B50","doi-asserted-by":"crossref","first-page":"e2301751","DOI":"10.1002\/smll.202301751","article-title":"Non-cardiotoxic tetradecanoic acid-2,4-dinitrophenol ester nanomicelles in microneedles exert potent anti-obesity effect by regulating adipocyte browning and lipogenesis","volume":"19","author":"Liang","year":"2023","journal-title":"Small"},{"key":"2026050914114949000_rbag052-B51","doi-asserted-by":"crossref","first-page":"e2309920","DOI":"10.1002\/adma.202309920","article-title":"Self-assembled oligopeptoplex-loaded dissolving microneedles for adipocyte-targeted anti-obesity gene therapy","volume":"36","author":"Choi","year":"2024","journal-title":"Adv Mater"},{"key":"2026050914114949000_rbag052-B52","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41467-025-56755-4","article-title":"Transdermal microneedle-assisted ultrasound-enhanced CRISPRa system to enable sono-gene therapy for obesity","volume":"16","author":"Li","year":"2025","journal-title":"Nat Commun"},{"key":"2026050914114949000_rbag052-B53","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.arr.2013.05.007","article-title":"Should visceral fat be reduced to increase longevity?","volume":"12","author":"Finelli","year":"2013","journal-title":"Ageing Res Rev"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag052\/67282462\/rbag052.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag052\/67282462\/rbag052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag052\/67282462\/rbag052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:12:03Z","timestamp":1778350323000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag052\/8512525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":53,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag052","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag052"}}