{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:04:09Z","timestamp":1779321849969,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC2405901"],"award-info":[{"award-number":["2022YFC2405901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471026"],"award-info":[{"award-number":["82471026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301030"],"award-info":[{"award-number":["82301030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Education Commission Research","award":["2022KJ205"],"award-info":[{"award-number":["2022KJ205"]}]},{"name":"Tianjin Natural Science Foundation for Jingjinji Collaboration","award":["23JCZXJC00240"],"award-info":[{"award-number":["23JCZXJC00240"]}]},{"name":"Tianjin Natural Science Foundation for Jingjinji Collaboration","award":["J230006"],"award-info":[{"award-number":["J230006"]}]},{"name":"Tianjin Natural Science Foundation for Jingjinji Collaboration","award":["H2023201903"],"award-info":[{"award-number":["H2023201903"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-1-052"],"award-info":[{"award-number":["2021-I2M-1-052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maxillofacial bone defects present a major challenge in clinical practice. Bone grafting and bone tissue engineering are limited by various side effects and potential risks, while local drug delivery is regarded as a convenient and efficient strategy for bone repair and regeneration. However, for bone tissue regeneration, a drug delivery system should not only release osteogenic drugs but also possess an appropriate morphology to provide structural support for cell proliferation and differentiation. Polymeric non-spherical counterparts may offer new osteogenic properties through altered cellular interactions, biodistribution, and immune responses, compared with spherical drug carriers. Poly(lactic-co-glycolic acid) (PLGA) has been widely used to prepare various drug carriers due to its excellent biocompatibility and controllable biodegradation. Shape regulation, surface modification and drug incorporation are effective approaches to impart distinct functions to PLGA particles for various biomedical applications. However, PLGA has inherent limitations, including poor hydrophilicity, acidic degradation products and a lack of functional ligands for cell attachment, which hinder its effectiveness in bone regeneration. To solve these problems, natural proteins were utilized to improve the bone\/cartilage regeneration of polymeric particles\/scaffolds through surface modification or physical complexation due to their excellent biocompatibility and biodegradability. In this study, we successfully developed simvastatin (SIM)-loaded disc-shaped PLGA microparticles with coarse surface (dPLGA) using W1\/O\/W2 followed by silk fibroin (SF) coating for hydrophilicity and biocompatibility improvement. In vitro and in vivo experiments revealed that SF-modified SIM-loaded dPLGA (SF-SIM@dPLGA) significantly promoted the osteogenic differentiation of stem cells and bone regeneration in cranial bone defects, indicating the superior osteoconductive and osteoinductive advantages arising from the physical morphology of particles and chemical effects. Additionally, SF-SIM@dPLGA demonstrated improved tissue adhesion and hemostatic ability. This novel PLGA non-spherical particle-based local delivery system provides a feasible strategy for practical maxillofacial bone repair due to the simple preparation procedures and enhanced bone regeneration performance.<\/jats:p>","DOI":"10.1093\/rb\/rbag053","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:42:32Z","timestamp":1773146552000},"source":"Crossref","is-referenced-by-count":0,"title":["Silk-coated PLGA non-spherical microparticles for simvastatin delivery in rat maxillofacial bone regeneration"],"prefix":"10.1093","volume":"13","author":[{"given":"Junjiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Chang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]},{"name":"Department of Genetics, School of Basic Medical Sciences , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Sui","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-547X","authenticated-orcid":false,"given":"Yanjing","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology , Tianjin 300070,","place":["China"]},{"name":"Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , Tianjin 300070,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"2026041522331482300_rbag053-B1","first-page":"224","article-title":"Bone grafts and biomaterials substitutes for bone defect repair: a review","volume":"2","author":"Wang","year":"2017","journal-title":"Bioact Mater"},{"key":"2026041522331482300_rbag053-B2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40729-017-0084-4","article-title":"Autogenous bone grafts in oral implantology-is it still a \u201cgold standard\u201d? A consecutive review of 279 patients with 456 clinical procedures","volume":"3","author":"Sakkas","year":"2017","journal-title":"Int J Implant Dent"},{"key":"2026041522331482300_rbag053-B3","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.3390\/ma16114117","article-title":"Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials","volume":"16","author":"Ferraz","year":"2023","journal-title":"Materials (Basel)"},{"key":"2026041522331482300_rbag053-B4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.actbio.2025.04.021","article-title":"3D-printed polycaprolactone scaffolds functionalized with poly(lactic-co-glycolic) acid microparticles enhance bone regeneration through tunable drug release","volume":"198","author":"Romero-Torrecilla","year":"2025","journal-title":"Acta Biomater"},{"key":"2026041522331482300_rbag053-B5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jare.2023.01.019","article-title":"A spatiotemporal drug release scaffold with antibiosis and bone regeneration for osteomyelitis","volume":"54","author":"Wu","year":"2023","journal-title":"J Adv Res"},{"key":"2026041522331482300_rbag053-B6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrrheum.2009.228","article-title":"Cell-free and cell-based approaches for bone regeneration","volume":"5","author":"Bueno","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"2026041522331482300_rbag053-B7","first-page":"346","article-title":"Poly(lactic-co-glycolic acid)-based composite bone-substitute materials","volume":"6","author":"Zhao","year":"2021","journal-title":"Bioact Mater"},{"key":"2026041522331482300_rbag053-B8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2019.12.039","article-title":"Engineering shape-defined PLGA microPlates for the sustained release of anti-inflammatory molecules","volume":"319","author":"Di Francesco","year":"2020","journal-title":"J Control Release"},{"key":"2026041522331482300_rbag053-B9","doi-asserted-by":"crossref","first-page":"102580","DOI":"10.1016\/j.cis.2021.102580","article-title":"Advances in design and applications of polymer brush modified anisotropic particles","volume":"300","author":"Pradhan","year":"2022","journal-title":"Adv Colloid Interface Sci"},{"key":"2026041522331482300_rbag053-B10","first-page":"2315","article-title":"Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration","volume":"6","author":"Lin","year":"2021","journal-title":"Bioact Mater"},{"key":"2026041522331482300_rbag053-B11","doi-asserted-by":"crossref","first-page":"e2301366","DOI":"10.1002\/adhm.202301366","article-title":"CGRP-Loaded porous microspheres protect BMSCs for alveolar bone regeneration in the periodontitis microenvironment","volume":"12","author":"Luo","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"2026041522331482300_rbag053-B12","doi-asserted-by":"crossref","first-page":"113807","DOI":"10.1016\/j.addr.2021.05.017","article-title":"Non-spherical micro- and nanoparticles for drug delivery: progress over 15 years","volume":"177","author":"Kapate","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"2026041522331482300_rbag053-B13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2015.03.027","article-title":"Structure-directing star-shaped block copolymers: supramolecular vesicles for the delivery of anticancer drugs","volume":"208","author":"Yang","year":"2015","journal-title":"J Control Release"},{"key":"2026041522331482300_rbag053-B14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jconrel.2009.10.014","article-title":"Size and shape effects in the biodistribution of intravascularly injected particles","volume":"141","author":"Decuzzi","year":"2010","journal-title":"J Control Release"},{"key":"2026041522331482300_rbag053-B15","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/ame2.70041","article-title":"Intratympanic dexamethasone microcrystals\/lidocaine-loaded PLGA non-spherical microparticles for local drug delivery to the inner ear","volume":"8","author":"Wang","year":"2025","journal-title":"Animal Model Exp Med"},{"key":"2026041522331482300_rbag053-B16","doi-asserted-by":"crossref","first-page":"111560","DOI":"10.1016\/j.colsurfb.2021.111560","article-title":"Polymeric non-spherical coarse microparticles fabricated by double emulsion-solvent evaporation for simvastatin delivery","volume":"199","author":"Zhang","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2026041522331482300_rbag053-B17","doi-asserted-by":"crossref","first-page":"30463","DOI":"10.1038\/srep30463","article-title":"Wrinkling non-spherical particles and its application in cell attachment promotion","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"2026041522331482300_rbag053-B18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41368-020-0073-y","article-title":"Effect of the nano\/microscale structure of biomaterial scaffolds on bone regeneration","volume":"12","author":"Zhu","year":"2020","journal-title":"Int J Oral Sci"},{"key":"2026041522331482300_rbag053-B19","doi-asserted-by":"crossref","first-page":"100662","DOI":"10.1016\/j.mtbio.2023.100662","article-title":"A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells","volume":"20","author":"Gao","year":"2023","journal-title":"Mater Today Bio"},{"key":"2026041522331482300_rbag053-B20","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1021\/acsomega.2c00846","article-title":"Non-mulberry silk fiber-based composite scaffolds containing millichannels for auricular cartilage regeneration","volume":"7","author":"Yao","year":"2022","journal-title":"ACS Omega"},{"key":"2026041522331482300_rbag053-B21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.colsurfb.2017.06.038","article-title":"Silk fibroin-coated PLGA dimpled microspheres for retarded release of simvastatin","volume":"158","author":"Qiao","year":"2017","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2026041522331482300_rbag053-B22","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.7150\/thno.74548","article-title":"Silk fibroin-based biomaterials for cartilage\/osteochondral repair","volume":"12","author":"Zhou","year":"2022","journal-title":"Theranostics"},{"key":"2026041522331482300_rbag053-B23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3390\/insects13030286","article-title":"The contribution of silk fibroin in biomedical engineering","volume":"13","author":"Lujerdean","year":"2022","journal-title":"Insects"},{"key":"2026041522331482300_rbag053-B24","doi-asserted-by":"crossref","first-page":"rbae146","DOI":"10.1093\/rb\/rbae146","article-title":"Azithromycin-loaded PLGA microspheres coated with silk fibroin ameliorate inflammation and promote periodontal tissue regeneration","volume":"12","author":"Ouyang","year":"2025","journal-title":"Regen Biomater"},{"key":"2026041522331482300_rbag053-B25","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3390\/molecules27092757","article-title":"Silk fibroin-based biomaterials for tissue engineering applications","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"2026041522331482300_rbag053-B26","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1002\/jbm.a.34947","article-title":"Fabrication of poly(lactic-co-glycolic acid) scaffolds containing silk fibroin scaffolds for tissue engineering applications","volume":"102","author":"Ju","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"2026041522331482300_rbag053-B27","doi-asserted-by":"crossref","first-page":"162902","DOI":"10.1016\/j.cej.2025.162902","article-title":"Poly(lactic-co-glycolic) acid porous microspheres for the sequential delivery of apoptotic vesicles and strontium in maxillofacial bone regeneration","volume":"513","author":"Liu","year":"2025","journal-title":"Chem Eng J"},{"key":"2026041522331482300_rbag053-B28","doi-asserted-by":"crossref","first-page":"129703","DOI":"10.1016\/j.cej.2021.129703","article-title":"PLGA hybrid porous microspheres as human periodontal ligament stem cell delivery carriers for periodontal regeneration","volume":"420","author":"Liu","year":"2021","journal-title":"Chem Eng J"},{"key":"2026041522331482300_rbag053-B29","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1038\/s41467-022-30813-7","article-title":"Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)","volume":"13","author":"Giles","year":"2022","journal-title":"Nat Commun"},{"key":"2026041522331482300_rbag053-B30","doi-asserted-by":"crossref","first-page":"e2219756120","DOI":"10.1073\/pnas.2219756120","article-title":"Regenerative engineering of long bones using the small molecule forskolin","volume":"120","author":"Awale","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026041522331482300_rbag053-B31","doi-asserted-by":"crossref","first-page":"2405255","DOI":"10.1002\/adfm.202405255","article-title":"Multifunctional hydrogel based on silk fibroin promotes tissue repair and regeneration","volume":"34","author":"Lin","year":"2024","journal-title":"Adv Funct Mater"},{"key":"2026041522331482300_rbag053-B32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.addr.2016.03.012","article-title":"Biocompatibility and safety of PLA and its copolymers","volume":"107","author":"Ramot","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"2026041522331482300_rbag053-B33","doi-asserted-by":"crossref","first-page":"7584","DOI":"10.1016\/j.biomaterials.2012.06.013","article-title":"The microclimate pH in poly(D, L-lactide-co-hydroxymethyl glycolide) microspheres during biodegradation","volume":"33","author":"Liu","year":"2012","journal-title":"Biomaterials"},{"key":"2026041522331482300_rbag053-B34","doi-asserted-by":"crossref","first-page":"114857","DOI":"10.1016\/j.addr.2023.114857","article-title":"Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding","volume":"198","author":"Wan","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"2026041522331482300_rbag053-B35","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1039\/D5MH01359C","article-title":"Leveraging solid-liquid interaction to fabricate drug-microsphere in site encapsulated bone-repair scaffolds","volume":"13","author":"Zhao","year":"2026","journal-title":"Mater Horiz"},{"key":"2026041522331482300_rbag053-B36","doi-asserted-by":"crossref","DOI":"10.3390\/gels11120995","article-title":"The design and development of an injectable thermoresponsive hydrogel for controlled simvastatin release in bone repair applications","volume":"11","author":"Simpson","year":"2025","journal-title":"Gels"},{"key":"2026041522331482300_rbag053-B37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.nutres.2010.03.004","article-title":"Simvastatin promotes osteoblast viability and differentiation via ras\/smad\/erk\/BMP-2 signaling pathway","volume":"30","author":"Chen","year":"2010","journal-title":"Nutr Res"},{"key":"2026041522331482300_rbag053-B38","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ijbiomac.2016.10.047","article-title":"Polyethylenimine\/silk fibroin multilayers deposited nanofibrics for cell culture","volume":"94","author":"Ye","year":"2017","journal-title":"Int J Biol Macromol"},{"key":"2026041522331482300_rbag053-B39","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1631\/jzus.B2300003","article-title":"Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine","volume":"24","author":"Hu","year":"2023","journal-title":"J Zhejiang Univ Sci B"},{"key":"2026041522331482300_rbag053-B40","doi-asserted-by":"crossref","first-page":"e2210517","DOI":"10.1002\/adma.202210517","article-title":"Silk fibroin and sericin differentially potentiate the paracrine and regenerative functions of stem cells through multiomics analysis","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater"},{"key":"2026041522331482300_rbag053-B41","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1021\/acsbiomaterials.1c00462","article-title":"Simvastatin-Incorporated drug delivery systems for bone regeneration","volume":"7","author":"Jin","year":"2021","journal-title":"ACS Biomater Sci Eng"},{"key":"2026041522331482300_rbag053-B42","doi-asserted-by":"crossref","first-page":"150546","DOI":"10.1016\/j.cej.2024.150546","article-title":"Gold capped mesoporous bioactive glass guides bone regeneration via BMSCs recruitment and drug adaptive release","volume":"487","author":"Zhou","year":"2024","journal-title":"Chem Eng J"},{"key":"2026041522331482300_rbag053-B43","doi-asserted-by":"crossref","first-page":"055012","DOI":"10.1088\/1748-605X\/aad2a9","article-title":"Silk fibroin-bioactive glass based advanced biomaterials: towards patient-specific bone grafts","volume":"13","author":"Midha","year":"2018","journal-title":"Biomed Mater"},{"key":"2026041522331482300_rbag053-B44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jare.2025.04.032","article-title":"Osteoimmunity-Regulating biospun 3D silk scaffold for bone regeneration in critical-size defects","volume":"80","author":"Zhang","year":"2026","journal-title":"J Adv Res"},{"key":"2026041522331482300_rbag053-B45","first-page":"223","article-title":"Simvastatin\/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF\/NOX2-associated ferroptosis while repairing bone defects","volume":"33","author":"Jing","year":"2024","journal-title":"Bioact Mater"},{"key":"2026041522331482300_rbag053-B46","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10059-011-0107-6","article-title":"Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt\/beta-catenin signaling","volume":"32","author":"Qiao","year":"2011","journal-title":"Mol Cells"},{"key":"2026041522331482300_rbag053-B47","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/0885328221995926","article-title":"Surface modification of the simvastatin factor-loaded silk fibroin promotes the healing of rotator cuff injury through beta-catenin signaling","volume":"36","author":"Hao","year":"2021","journal-title":"J Biomater Appl"},{"key":"2026041522331482300_rbag053-B48","doi-asserted-by":"crossref","first-page":"035009","DOI":"10.1088\/1758-5090\/acc68f","article-title":"Development of a biomimetic arch-like 3D bioprinted construct for cartilage regeneration using gelatin methacryloyl and silk fibroin-gelatin bioinks","volume":"15","author":"Chakraborty","year":"2023","journal-title":"Biofabrication"},{"key":"2026041522331482300_rbag053-B49","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"2026041522331482300_rbag053-B50","doi-asserted-by":"crossref","first-page":"e70020","DOI":"10.1111\/cpr.70020","article-title":"YTHDC1 modulates the osteogenic capacity of hPDLSCs via wnt\/beta-Catenin signalling pathway for the treatment of bone defects in osteoporosis rats","volume":"58","author":"Tan","year":"2025","journal-title":"Cell Prolif"},{"key":"2026041522331482300_rbag053-B51","doi-asserted-by":"crossref","first-page":"e13747","DOI":"10.1111\/cpr.13747","article-title":"Role of Wnt5a in modulation of osteoporotic adipose-derived stem cells and osteogenesis","volume":"58","author":"Liu","year":"2025","journal-title":"Cell Prolif"},{"key":"2026041522331482300_rbag053-B52","doi-asserted-by":"crossref","first-page":"e13624","DOI":"10.1111\/cpr.13624","article-title":"MicroRNA-29c-tetrahedral framework nucleic acids: towards osteogenic differentiation of mesenchymal stem cells and bone regeneration in critical-sized calvarial defects","volume":"57","author":"Sun","year":"2024","journal-title":"Cell Prolif"},{"key":"2026041522331482300_rbag053-B53","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202208639","article-title":"Bone repair biomaterials: a perspective from immunomodulation","volume":"32","author":"Wang","year":"2022","journal-title":"Adv Funct Materials"},{"key":"2026041522331482300_rbag053-B54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/rb\/rbaa006","article-title":"Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration","volume":"7","author":"Xie","year":"2020","journal-title":"Regen Biomater"},{"key":"2026041522331482300_rbag053-B55","doi-asserted-by":"crossref","first-page":"117256","DOI":"10.1016\/j.carbpol.2020.117256","article-title":"Surface roughness of silk fibroin\/alginate microspheres for rapid hemostasis in vitro and in vivo","volume":"253","author":"Huang","year":"2021","journal-title":"Carbohydr Polym"},{"key":"2026041522331482300_rbag053-B56","doi-asserted-by":"crossref","first-page":"e2201798","DOI":"10.1002\/adhm.202201798","article-title":"Instant and tough adhesives for rapid gastric perforation and traumatic pneumothorax sealing","volume":"11","author":"Liu","year":"2022","journal-title":"Adv Healthc Mater"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag053\/67294789\/rbag053.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag053\/67294789\/rbag053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag053\/67294789\/rbag053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:33:33Z","timestamp":1776306813000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag053\/8513515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":56,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag053","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag053"}}