{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:05:23Z","timestamp":1779797123166,"version":"3.53.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":120,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370672"],"award-info":[{"award-number":["82370672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0366"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0366"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Medical Leading Talents Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health challenge, yet the available therapeutic options remain limited. Evidence suggests that NAFLD may advance to more serious conditions, including steatohepatitis or cirrhosis, which are associated with poor outcomes. Current drug therapies exhibit insufficient therapeutic efficacy due to short half-life and premature clearance. In this work, we elucidate the critical impact of endoplasmic reticulum stress (ERS) on inflammatory process associated with NAFLD using bioinformatics tools. By analysing single-cell RNA sequencing data from an animal model of NAFLD, we identified hepatocytes as the primary cell type implicated in ERS. Melatonin (Mel), a compound known for its antioxidative properties, also modulates the ERS pathway, suggesting its potential to slow NAFLD progression. To exploit this therapeutic potential, we developed a nanoparticle (NP), GalNAc-MM@PLGA\/Mel, which incorporates engineered macrophage membranes to specifically target hepatocytes and mitigate ERS. The addition of GalNAc moieties on the membrane significantly enhanced the ability of NPs to specifically bind to hepatocytes. Moreover, Mel, delivered through this platform, effectively reduced inflammation and lipid accumulation by inhibiting both the ERS pathway and its downstream NF-\u03baB signaling cascade. Consequently, this engineered NP-based strategy offers a promising, safe and cost-efficient approach to managing NAFLD.<\/jats:p>","DOI":"10.1093\/rb\/rbag084","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:48:19Z","timestamp":1777376899000},"source":"Crossref","is-referenced-by-count":0,"title":["Cell membrane-coated nanoparticles against non-alcoholic fatty liver disease via regulating endoplasmic reticulum stress"],"prefix":"10.1093","volume":"13","author":[{"given":"Weiwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhui","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]},{"name":"Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longpo","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering, Chongqing Medical University , Chongqing, 400016,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuojin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, 400010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"2026052607151045700_rbag084-B1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"2026052607151045700_rbag084-B2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026052607151045700_rbag084-B3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cell.2018.08.020","article-title":"ER stress drives 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