{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:59:21Z","timestamp":1782233961226,"version":"3.54.5"},"reference-count":68,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":126,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surface bioinertness-induced fibrosis at and within 3D-printed porous titanium implants critically impairs their repair efficacy. Surface bioactive and evenly distributed coating construction represents an ideal strategy to address this challenge. Herein, a porous titanium alloy scaffold with an appropriate fluid dynamics microenvironment was prepared using computational fluid dynamics simulations and selective laser melting technology. Subsequently, a uniform nano-hydroxyapatite (nHA) coating with about 30\u2009\u03bcm thickness and good bonding strength was fabricated on the chemically pretreated scaffold via surface engineering and gradient liquid-phase impregnation. The nHA coating significantly promoted the adhesion, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells on the scaffold. In a beagle intramuscular model, the rhombic dodecahedron lattice exhibited superior osteoinduction to diamond and hexagonal close-packed lattices, owing to deeper fluid penetration and uniform shear stress. Furthermore, in a rabbit femoral condyle critical-sized defect model, the topology-optimized, surface-modified titanium alloy scaffold exhibited superior interfacial osseointegration and internal bone regeneration. This study not only offers a new approach to addressing current challenges in clinical titanium implant applications but also provides novel insights into the design of 3D-printed functionalized implants.<\/jats:p>","DOI":"10.1093\/rb\/rbag090","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:32:21Z","timestamp":1777980741000},"source":"Crossref","is-referenced-by-count":0,"title":["Topological optimization synergized with a high-activity nano-hydroxyapatite coating to enhance bone regeneration in a porous titanium alloy scaffold"],"prefix":"10.1093","volume":"13","author":[{"given":"Peng","family":"Zhao","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064,","place":["China"]},{"name":"College of Biomedical Engineering, Sichuan University , Chengdu 610064,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushuan","family":"Jia","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064,","place":["China"]},{"name":"College of Biomedical Engineering, Sichuan University , Chengdu 610064,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064,","place":["China"]},{"name":"College of Biomedical Engineering, Sichuan University , Chengdu 610064,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"You","sequence":"additional","affiliation":[{"name":"Changzhou Jishuo Medical Device Co., Ltd , Changzhou 213146,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064,","place":["China"]},{"name":"College of Biomedical Engineering, Sichuan University , Chengdu 610064,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064,","place":["China"]},{"name":"College of Biomedical Engineering, Sichuan University , Chengdu 610064,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064,","place":["China"]},{"name":"College of Biomedical 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