{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:34:11Z","timestamp":1791142451489,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":128,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFC2420800"],"award-info":[{"award-number":["2024YFC2420800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172222"],"award-info":[{"award-number":["82172222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572881"],"award-info":[{"award-number":["82572881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic skin wounds remain a clinical challenge due to impaired extracellular matrix (ECM) reconstruction and dysregulated immune responses. Biomaterials that simultaneously support matrix formation and modulate the wound immune microenvironment are, therefore, highly desirable. Here, we developed a mesoporous bioactive glass\u2013recombinant collagen III nanocomposite capsule (Cap-ReCol III), in which recombinant collagen III is adsorbed onto mesoporous bioactive glass nanoparticles to form an integrated organic\u2013inorganic unit. Cap-ReCol III exhibited a well-defined mesoporous structure and favorable physicochemical properties. In vitro, it showed excellent cytocompatibility and significantly enhanced fibroblast proliferation, migration and contractility, accompanied by increased expression of \u03b1-smooth muscle actin and collagen-related markers. In a full-thickness mouse wound model, Cap-ReCol III accelerated wound closure and promoted granulation tissue formation and collagen deposition. Importantly, Cap-ReCol III modulated the immune microenvironment by reducing neutrophil accumulation and granzyme B+ CD8+ T cells, while increasing regulatory T cells and IL-13+ CD8+ T-cell subsets associated with tissue repair. Adoptive transfer experiments in Rag2-\/- mice further confirmed the essential role of adaptive immunity in this process. Overall, Cap-ReCol III promotes wound healing by coordinating ECM remodeling and adaptive immune modulation, providing a promising strategy for skin regeneration.<\/jats:p>","DOI":"10.1093\/rb\/rbag092","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:45:16Z","timestamp":1778154316000},"source":"Crossref","is-referenced-by-count":1,"title":["Mesoporous bioactive glass\u2013recombinant collagen III nanocomposite capsule promotes skin wound healing via adaptive immune modulation"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3794-4466","authenticated-orcid":false,"given":"Yi","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-2300","authenticated-orcid":false,"given":"Jian","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai, 200127,","place":["China"]},{"name":"Shanghai Depeac Biotechnology Co., Ltd. , Shanghai, 201900,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihang","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Trautec Medical Technology Inc. , Jintan District, Jiangsu Province, 213200,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujie","family":"Zhu","sequence":"additional","affiliation":[{"name":"No. 2 Daixi Beauty Science and Technology Innovation Center, Zhejiang Silicon-based Life Co., Ltd. , Hangzhou City, Zhejiang Province, 310000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laboratory of Advanced Materials, College of Smart Materials and Future Energy, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai, 200433,","place":["China"]},{"name":"Shanghai Qiran Biotechnology Co, Ltd. , Shanghai, 201700,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai, 200127,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laboratory of Advanced Materials, College of Smart Materials and Future Energy, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai, 200433,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 200011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"2026061002263859400_rbag092-B1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jval.2017.07.007","article-title":"An economic evaluation of the impact, cost, and Medicare policy implications of chronic nonhealing wounds","volume":"21","author":"Nussbaum","year":"2018","journal-title":"Value Health"},{"key":"2026061002263859400_rbag092-B2","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2026061002263859400_rbag092-B3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.addr.2017.12.007","article-title":"Fibrin-based delivery strategies for acute and chronic wound healing","volume":"129","author":"Heher","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"2026061002263859400_rbag092-B4","first-page":"159","article-title":"Chronic wounds: evaluation and management","volume":"101","author":"Bowers","year":"2020","journal-title":"Am Fam Physician"},{"key":"2026061002263859400_rbag092-B5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2217\/rme.16.4","article-title":"Potential roles of suppressor of cytokine signaling in wound healing","volume":"11","author":"Feng","year":"2016","journal-title":"Regen Med"},{"key":"2026061002263859400_rbag092-B6","doi-asserted-by":"crossref","first-page":"rbac065","DOI":"10.1093\/rb\/rbac065","article-title":"Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior","volume":"9","author":"Sousa","year":"2022","journal-title":"Regen Biomater"},{"key":"2026061002263859400_rbag092-B7","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41419-021-04294-3","article-title":"The emerging roles of neutrophil extracellular traps in wound healing","volume":"12","author":"Zhu","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026061002263859400_rbag092-B8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"2026061002263859400_rbag092-B9","first-page":"99","article-title":"Macrophage functions in wound healing","volume":"13","author":"Kloc","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"2026061002263859400_rbag092-B10","doi-asserted-by":"crossref","first-page":"123378","DOI":"10.1016\/j.carbpol.2025.123378","article-title":"Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerates cachectic wound healing and reduces scar hyperplasia","volume":"357","author":"Chen","year":"2025","journal-title":"Carbohydr Polym"},{"key":"2026061002263859400_rbag092-B11","first-page":"49","article-title":"Regulatory T cells in skin regeneration and wound healing","volume":"10","author":"Knoedler","year":"2023","journal-title":"Mil Med Res"},{"key":"2026061002263859400_rbag092-B12","doi-asserted-by":"crossref","first-page":"eadn5409","DOI":"10.1126\/sciadv.adn5409","article-title":"Functional tendon regeneration is driven by regulatory T cells and IL-33 signaling","volume":"11","author":"Arvind","year":"2025","journal-title":"Sci Adv"},{"key":"2026061002263859400_rbag092-B13","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1038\/s41467-024-51353-2","article-title":"Local administration of regulatory T cells promotes tissue healing","volume":"15","author":"Nayer","year":"2024","journal-title":"Nat Commun"},{"key":"2026061002263859400_rbag092-B14","doi-asserted-by":"crossref","first-page":"100121","DOI":"10.1016\/j.mtbio.2021.100121","article-title":"Mesoporous bioactive glasses for regenerative medicine","volume":"11","author":"Vallet-Regi","year":"2021","journal-title":"Mater Today Bio"},{"key":"2026061002263859400_rbag092-B15","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1021\/acsnano.3c01370","article-title":"Flexible bioactive glass nanofiber-based self-expanding cryogels with superelasticity and bioadhesion enabling hemostasis and wound healing","volume":"17","author":"Lu","year":"2023","journal-title":"ACS Nano"},{"key":"2026061002263859400_rbag092-B16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/bioengineering4010015","article-title":"Composite biomaterials based on Sol-Gel mesoporous silicate glasses: a review","volume":"4","author":"Baino","year":"2017","journal-title":"Bioengineering"},{"key":"2026061002263859400_rbag092-B17","first-page":"436","article-title":"Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications","volume":"34","author":"Cui","year":"2024","journal-title":"Bioact Mater"},{"key":"2026061002263859400_rbag092-B18","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1039\/D4BM01284D","article-title":"Biocompatible recombinant type III collagen enhancing skin repair and anti-wrinkle effects","volume":"12","author":"Ye","year":"2024","journal-title":"Biomater Sci"},{"key":"2026061002263859400_rbag092-B19","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jid.2024.08.013","article-title":"Type III collagen regulates matrix architecture and mechanosensing during wound healing","volume":"145","year":"2025","journal-title":"J Invest Dermatol"},{"key":"2026061002263859400_rbag092-B20","doi-asserted-by":"crossref","first-page":"136679","DOI":"10.1016\/j.ijbiomac.2024.136679","article-title":"Preparation of recombinant type I collagen (PF-I-80) and its functional characterization and biomedical applications in wound healing","volume":"282","author":"Zhang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"2026061002263859400_rbag092-B21","doi-asserted-by":"crossref","first-page":"e831","DOI":"10.1002\/ctm2.831","article-title":"Targeting inflammation with collagen","volume":"12","author":"Schwarz","year":"2022","journal-title":"Clinic Transl Med"},{"key":"2026061002263859400_rbag092-B22","first-page":"301","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2026061002263859400_rbag092-B23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s42825-023-00136-4","article-title":"Recent progresses of collagen dressings for chronic skin wound healing","volume":"5","author":"Shi","year":"2023","journal-title":"Collagen Leather"},{"key":"2026061002263859400_rbag092-B24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12938-019-0647-0","article-title":"Processing of collagen based biomaterials and the resulting materials properties","volume":"18","author":"Meyer","year":"2019","journal-title":"Biomed Eng Online"},{"key":"2026061002263859400_rbag092-B25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s42825-024-00164-8","article-title":"Recent advances of collagen composite biomaterials for biomedical engineering: antibacterial functionalization and 3D-printed architecturalization","volume":"6","author":"Zheng","year":"2024","journal-title":"Collagen Leather"},{"key":"2026061002263859400_rbag092-B26","doi-asserted-by":"crossref","first-page":"0134","DOI":"10.34133\/bmr.0134","article-title":"Bioactive glasses: advancing skin tissue repair through multifunctional mechanisms and innovations","volume":"29","author":"Ren","year":"2025","journal-title":"Biomater Res"},{"key":"2026061002263859400_rbag092-B27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/cells13060491","article-title":"Wound repair and Ca2+ signalling interplay: the role of Ca2+ channels in skin","volume":"13","author":"Bonsignore","year":"2024","journal-title":"Cells"},{"key":"2026061002263859400_rbag092-B28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol Rev"},{"key":"2026061002263859400_rbag092-B29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/wound.2012.0383","article-title":"Neutrophils and wound repair: positive actions and negative reactions","volume":"2","author":"Wilgus","year":"2013","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2026061002263859400_rbag092-B30","doi-asserted-by":"crossref","first-page":"1560578","DOI":"10.3389\/fimmu.2025.1560578","article-title":"The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Immunol"},{"key":"2026061002263859400_rbag092-B31","doi-asserted-by":"crossref","first-page":"2314500","DOI":"10.1002\/adfm.202314500","article-title":"An ROS-Scavenging Treg-Recruiting hydrogel patch for diabetic wound healing","volume":"34","author":"Qu","year":"2024","journal-title":"Adv Funct Mater"},{"key":"2026061002263859400_rbag092-B32","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/eji.201747395","article-title":"Regulatory T cells are required for normal and activin-promoted wound repair in mice","volume":"48","author":"Haertel","year":"2018","journal-title":"Eur J Immunol"},{"key":"2026061002263859400_rbag092-B33","doi-asserted-by":"crossref","first-page":"H948","DOI":"10.1152\/ajpheart.00082.2021","article-title":"Chronic Porphyromonas gingivalis lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8+ T cells","volume":"321","author":"Zaidi","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026061002263859400_rbag092-B34","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jaci.2023.11.916","article-title":"Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease","volume":"153","author":"Koga","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"2026061002263859400_rbag092-B35","doi-asserted-by":"crossref","first-page":"H581","DOI":"10.1152\/ajpheart.00112.2019","article-title":"CD8+ T-cells negatively regulate inflammation post-myocardial infarction","volume":"317","author":"Ilatovskaya","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026061002263859400_rbag092-B36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.37706","article-title":"13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis","volume":"65","author":"Fuschiotti","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2026061002263859400_rbag092-B37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/wound.2021.0059","article-title":"The role of T lymphocytes in cutaneous scarring","volume":"11","author":"Short","year":"2022","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2026061002263859400_rbag092-B38","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12951-025-03398-8","article-title":"Insulin\/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation","volume":"23","author":"Liu","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"2026061002263859400_rbag092-B39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-immunol-032712-095906","article-title":"Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease","volume":"31","author":"Van Dyken","year":"2013","journal-title":"Annu Rev Immunol"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag092\/68261175\/rbag092.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag092\/68261175\/rbag092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag092\/68261175\/rbag092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:27:17Z","timestamp":1781072837000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag092\/8675144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag092","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag092"}}