{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:43:41Z","timestamp":1786121021885,"version":"build-2736575974"},"reference-count":62,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270517"],"award-info":[{"award-number":["82270517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association CAS","doi-asserted-by":"publisher","award":["2023263"],"award-info":[{"award-number":["2023263"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although hydrophobic drugs demonstrate the promising therapeutic efficacy for peripheral artery disease in vitro, their in vivo performance is often hindered by low bioavailability due to inherent hydrophobicity. To address this, an injectable, self-healing and curcumin-sustained-release hydrogel (CGP hydrogel) using a gelatin\/polyvinyl alcohol hydrogel (GP hydrogel) was developed. The CGP hydrogel effectively preserved the DPPH radical-scavenging activity of curcumin at room temperature. Meanwhile, in the murine hindlimb ischemia model, a single intramuscular injection of CGP following femoral artery ligation significantly improved the motor function of the ischemic limb compared to curcumin suspension. This superior therapeutic outcome is attributed to the sustained release of curcumin from the CGP hydrogel. Mechanistically, we found that CGP, but not GP, inhibited the expression of Atp6v0d2 in ischemic skeletal muscle cells and suppressed ischemia-induced autophagy. The inhibition of autophagy may mitigate tissue and cellular necrosis and promote the expression of Myogenin. Furthermore, CGP reduced the expression of pro-fibrotic factors such as Tgfb1 and Ctgf and prevented skeletal muscle fibrosis. In summary, the CGP hydrogel, through its sustained release of curcumin, inhibits ischemia-induced autophagy, alleviates necrosis and fibrosis in skeletal muscle tissue and preserves motor function in the ischemic limb.<\/jats:p>","DOI":"10.1093\/rb\/rbag103","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:49:02Z","timestamp":1782992942000},"source":"Crossref","is-referenced-by-count":0,"title":["An injectable self-healing curcumin-sustained-release hydrogel for lower limb ischemia via autophagy inhibition by\n                    <i>Atp6v0d2<\/i>\n                    downregulation"],"prefix":"10.1093","volume":"13","author":[{"given":"Hanfei","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China"},{"name":"Institute of Vascular Surgery, Fudan University, Shanghai 200030, China"},{"name":"National Clinical Research Center for Interventional Medicine, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]},{"name":"Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University , Chengdu 610031,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonglei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China"},{"name":"Institute of Vascular Surgery, Fudan University, Shanghai 200030, China"},{"name":"National Clinical Research Center for Interventional Medicine, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-8143","authenticated-orcid":false,"given":"Xuanyong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China"},{"name":"Institute of Vascular Surgery, Fudan University, Shanghai 200030, China"},{"name":"National Clinical Research Center for Interventional Medicine, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China"},{"name":"National Clinical Research Center for Interventional Medicine, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China"},{"name":"Institute of Vascular Surgery, Fudan University, Shanghai 200030, China"},{"name":"National Clinical Research Center for Interventional Medicine, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Xuhui Central Hospital , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China"},{"name":"Institute of Vascular Surgery, Fudan University, Shanghai 200030, China"},{"name":"National Clinical Research Center for Interventional Medicine, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"2026080621570297300_rbag103-B1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.amjmed.2019.04.043","article-title":"Peripheral artery disease: past, present, and future","volume":"132","author":"Campia","year":"2019","journal-title":"Am J Med"},{"key":"2026080621570297300_rbag103-B2","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics\u20142020 update: a report from the American heart association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"2026080621570297300_rbag103-B3","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1161\/CIR.0000000000001005","article-title":"Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions: a scientific statement from the American heart association","volume":"144","author":"Criqui","year":"2021","journal-title":"Circulation"},{"key":"2026080621570297300_rbag103-B4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.mcna.2013.03.009","article-title":"Peripheral arterial disease and bypass surgery in the diabetic lower limb","volume":"97","author":"Albayati","year":"2013","journal-title":"Med Clin North Am"},{"key":"2026080621570297300_rbag103-B5","doi-asserted-by":"crossref","first-page":"e1313","DOI":"10.1161\/CIR.0000000000001251","article-title":"2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS guideline for the management of lower extremity peripheral artery disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Gornik","year":"2024","journal-title":"Circulation"},{"key":"2026080621570297300_rbag103-B6","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.5966\/sctm.2014-0049","article-title":"Concise review: injectable biomaterials for the treatment of myocardial infarction and peripheral artery disease: translational challenges and progress","volume":"3","author":"Ungerleider","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"2026080621570297300_rbag103-B7","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1152\/japplphysiol.00585.2017","article-title":"Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease","volume":"123","author":"Baker","year":"2017","journal-title":"J Appl Physiol"},{"key":"2026080621570297300_rbag103-B8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/jama.2021.2536","article-title":"Effect of low-intensity vs high-intensity home-based walking exercise on walk distance in patients with peripheral artery disease: the LITE randomized clinical trial","volume":"325","author":"McDermott","year":"2021","journal-title":"JAMA"},{"key":"2026080621570297300_rbag103-B9","doi-asserted-by":"crossref","first-page":"999386","DOI":"10.3389\/fphar.2022.999386","article-title":"Systematic review and meta-analysis of the intervention effect of curcumin on rodent models of myocardial infarction","volume":"13","author":"Pang","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026080621570297300_rbag103-B10","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.ijbiomac.2021.10.210","article-title":"Structural interplay between curcumin and soy protein to improve the water-solubility and stability of curcumin","volume":"193","author":"Wang","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"2026080621570297300_rbag103-B11","doi-asserted-by":"crossref","first-page":"148969","DOI":"10.1016\/j.ijbiomac.2025.148969","article-title":"Polysaccharide hydrogel loaded with dual-drug liposomes for accelerating diabetic wound healing through mitochondrial protection and anti-inflammatory activity","volume":"334","author":"Guo","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026080621570297300_rbag103-B12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/molecules28010262","article-title":"Novel curcumin arginine salt: a solution for poor solubility and potential anticancer activities","volume":"28","author":"Fatease","year":"2022","journal-title":"Molecules"},{"key":"2026080621570297300_rbag103-B13","doi-asserted-by":"crossref","first-page":"2510243","DOI":"10.1002\/adfm.202510243","article-title":"An ultrasound-responsive hydrogel for diabetic wound electrotherapy based on interfacial ion\/electron transfer","volume":"35","author":"Wang","year":"2025","journal-title":"Adv Funct Mater"},{"key":"2026080621570297300_rbag103-B14","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1038\/s41598-020-60352-4","article-title":"Development of a two-stage limb ischemia model to better simulate human peripheral artery disease","volume":"10","author":"Krishna","year":"2020","journal-title":"Sci Rep"},{"key":"2026080621570297300_rbag103-B15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.colsurfb.2015.11.017","article-title":"Fabrication of multi-biofunctional gelatin-based electrospun fibrous scaffolds for enhancement of osteogenesis of mesenchymal stem cells","volume":"138","author":"Lin","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2026080621570297300_rbag103-B16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10856-016-5700-y","article-title":"Analysis of friction between articular cartilage and polyvinyl alcohol hydrogel artificial cartilage","volume":"27","author":"Li","year":"2016","journal-title":"J Mater Sci Mater Med"},{"key":"2026080621570297300_rbag103-B17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.actbio.2014.12.013","article-title":"In situ DOX-calcium phosphate mineralized CPT-amphiphilic gelatin nanoparticle for intracellular controlled sequential release of multiple drugs","volume":"15","author":"Li","year":"2015","journal-title":"Acta Biomater"},{"key":"2026080621570297300_rbag103-B18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/21691401.2014.909823","article-title":"Amphiphilic polyvinyl alcohol adsorbent for the removal of low-density lipoprotein","volume":"43","author":"Yu","year":"2015","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"2026080621570297300_rbag103-B19","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1002\/adma.201600284","article-title":"An injectable self-assembling collagen\u2013gold hybrid hydrogel for combinatorial antitumor photothermal\/photodynamic therapy","volume":"28","author":"Xing","year":"2016","journal-title":"Adv Mat"},{"key":"2026080621570297300_rbag103-B20","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.3390\/ijms19082198","article-title":"Injectable and self-healing chitosan hydrogel based on imine bonds: design and therapeutic applications","volume":"19","author":"Xu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026080621570297300_rbag103-B21","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.7150\/thno.56266","article-title":"Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+\/curcumin from injectable self-healing hydrogels","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"2026080621570297300_rbag103-B22","doi-asserted-by":"crossref","first-page":"120952","DOI":"10.1016\/j.ijpharm.2021.120952","article-title":"Development of dual crosslinked mumio-based hydrogel dressing for wound healing application: physico-chemistry and antimicrobial activity","volume":"607","author":"Zandraa","year":"2021","journal-title":"Int J Pharm"},{"key":"2026080621570297300_rbag103-B23","doi-asserted-by":"crossref","first-page":"167153","DOI":"10.1016\/j.jmmm.2020.167153","article-title":"Magnetic hydrogel based shoe insoles for prevention of diabetic foot","volume":"514","author":"Patwa","year":"2020","journal-title":"J Magn Magn Mater"},{"key":"2026080621570297300_rbag103-B24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10971-021-05584-0","article-title":"Facile fabrication and characterization of high-performance Borax-PVA hydrogel","volume":"101","author":"Wang","year":"2022","journal-title":"J Solgel Sci Technol"},{"key":"2026080621570297300_rbag103-B25","doi-asserted-by":"crossref","first-page":"102501","DOI":"10.1016\/j.jddst.2021.102501","article-title":"Fabrication of scaffold based on gelatin and polycaprolactone (PCL) for wound dressing application","volume":"63","author":"El Fawal","year":"2021","journal-title":"J Drug Deliv Sci Technol"},{"key":"2026080621570297300_rbag103-B26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.msec.2015.05.077","article-title":"Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells","volume":"55","author":"Hatamie","year":"2015","journal-title":"Mater Sci Eng C"},{"key":"2026080621570297300_rbag103-B27","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1038\/s41598-024-57054-6","article-title":"Non-fluorescent transient states of tyrosine as a basis for label-free protein conformation and interaction studies","volume":"14","author":"Bagheri","year":"2024","journal-title":"Sci Rep"},{"key":"2026080621570297300_rbag103-B28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s13738-017-1236-4","article-title":"Photoluminescence and electrochemical investigation of curcumin-reduced graphene oxide sheets","volume":"15","author":"Hatamie","year":"2018","journal-title":"J Iran Chem Soc"},{"key":"2026080621570297300_rbag103-B29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mattod.2025.02.003","article-title":"An ultrasound-responsive hydrogel with piezoelectric-enhanced electrokinetic effect accelerates neurovascular regeneration for diabetic wound healing","volume":"84","author":"Wang","year":"2025","journal-title":"Mater Today"},{"key":"2026080621570297300_rbag103-B30","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"2026080621570297300_rbag103-B31","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/ja069838y","article-title":"The Merck index: an encyclopedia of chemicals, drugs, and biologicals, 14th ed. Edited by Maryadele J. O\u2019Neil (Editor), Patricia E. Heckelman (Senior Associate Editor), Cherie B. Koch (Associate Editor), and Kristin J. Roman (Assistant Editor). Merck and Co., Inc.: Whitehouse Station, NJ. 2006;2564 pp. $125.00. ISBN 0-911910-00-X","volume":"129","author":"Anonymous","year":"2007","journal-title":"J Am Chem Soc"},{"key":"2026080621570297300_rbag103-B32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpharm.2010.10.041","article-title":"Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity","volume":"403","author":"Kim","year":"2011","journal-title":"Int J Pharm"},{"key":"2026080621570297300_rbag103-B33","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.3390\/ijms241411439","article-title":"Flexible curcumin-loaded Zn-MOF hydrogel for long-term drug release and antibacterial activities","volume":"24","author":"Li","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026080621570297300_rbag103-B34","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/1759-7714.13904","article-title":"Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy","volume":"12","author":"Tang","year":"2021","journal-title":"Thorac Cancer"},{"key":"2026080621570297300_rbag103-B35","doi-asserted-by":"crossref","first-page":"112964","DOI":"10.1016\/j.intimp.2024.112964","article-title":"Effects of curcumin nanoparticles on the proliferation and migration of human ovarian cancer cells assessed through the NF-\u03baB\/PRL-3 signaling pathway","volume":"141","author":"Liu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"2026080621570297300_rbag103-B36","doi-asserted-by":"crossref","first-page":"12362","DOI":"10.3390\/ijms232012362","article-title":"Differential cytotoxicity of curcumin-loaded micelles on human tumor and stromal cells","volume":"23","author":"Do","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026080621570297300_rbag103-B37","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.1038\/s41598-025-93451-1","article-title":"Synthesis and antitumor evaluation of amino acid conjugates of monocarbonyl curcumin in hepatocellular carcinoma cell","volume":"15","author":"Cao","year":"2025","journal-title":"Sci Rep"},{"key":"2026080621570297300_rbag103-B38","doi-asserted-by":"crossref","first-page":"e0290382","DOI":"10.1371\/journal.pone.0290382","article-title":"A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain","volume":"18","author":"Zhang","year":"2023","journal-title":"PLoS One"},{"key":"2026080621570297300_rbag103-B39","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.matbio.2015.11.004","article-title":"V-type ATPase proton pump expression during enamel formation","volume":"52\u201354","author":"Sarkar","year":"2016","journal-title":"Matrix Biol"},{"key":"2026080621570297300_rbag103-B40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s12964-024-01998-9","article-title":"V-ATPase in cancer: mechanistic insights and therapeutic potentials","volume":"22","author":"Chen","year":"2024","journal-title":"Cell Commun Signal"},{"key":"2026080621570297300_rbag103-B41","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/15548627.2019.1569916","article-title":"The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion","volume":"15","author":"Xia","year":"2019","journal-title":"Autophagy"},{"key":"2026080621570297300_rbag103-B42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"2026080621570297300_rbag103-B43","doi-asserted-by":"crossref","first-page":"102849","DOI":"10.1016\/j.pdpdt.2022.102849","article-title":"Effects of curcumin-mediated photodynamic therapy on autophagy and epithelial-mesenchymal transition of lung cancer cells","volume":"38","author":"Shao","year":"2022","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"2026080621570297300_rbag103-B44","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jcsm.12587","article-title":"Sarcopenia and peripheral arterial disease: a systematic review","volume":"11","author":"Pizzimenti","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2026080621570297300_rbag103-B45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"2026080621570297300_rbag103-B46","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.avsg.2021.01.076","article-title":"Sarcopenia as a prognostic factor in peripheral arterial disease: descriptive review","volume":"74","author":"Ferreira","year":"2021","journal-title":"Ann Vasc Surg"},{"key":"2026080621570297300_rbag103-B47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00210-012-0726-2","article-title":"Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia\u2013reperfusion in rat skeletal muscle","volume":"385","author":"Hosseinzadeh","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2026080621570297300_rbag103-B48","doi-asserted-by":"crossref","first-page":"2309499019874470","DOI":"10.1177\/2309499019874470","article-title":"Inhibitory effect of edaravone on systemic inflammation and local damage in skeletal muscles following long-term ischemia to murine hind limb","volume":"27","author":"Yokoyama","year":"2019","journal-title":"J Orthop Surg"},{"key":"2026080621570297300_rbag103-B49","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev Cell"},{"key":"2026080621570297300_rbag103-B50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.31083\/j.fbl2706175","article-title":"miR-4463 regulates hypoxia-induced autophagy and apoptosis by targeting ULK1 in endothelial cells","volume":"27","author":"He","year":"2022","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2026080621570297300_rbag103-B51","doi-asserted-by":"crossref","first-page":"175569","DOI":"10.1016\/j.ejphar.2023.175569","article-title":"Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction","volume":"943","author":"Li","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"2026080621570297300_rbag103-B52","doi-asserted-by":"crossref","first-page":"106957","DOI":"10.1016\/j.phrs.2023.106957","article-title":"SIRT1 is a regulator of autophagy: implications for the progression and treatment of myocardial ischemia-reperfusion","volume":"199","author":"Ding","year":"2024","journal-title":"Pharmacol Res"},{"key":"2026080621570297300_rbag103-B53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00408-024-00701-6","article-title":"Neutralization of CX3CL1 attenuates TGF-\u03b2-induced fibroblast differentiation through NF-\u03baB activation and mitochondrial dysfunction in airway fibrosis","volume":"202","author":"Cheng","year":"2024","journal-title":"Lung"},{"key":"2026080621570297300_rbag103-B54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1152\/physiolgenomics.00047.2007","article-title":"Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains","volume":"30","author":"Chalothorn","year":"2007","journal-title":"Physiol Genomics"},{"key":"2026080621570297300_rbag103-B55","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbrc.2021.03.031","article-title":"Myogenin suppresses apoptosis induced by angiotensin II in human induced pluripotent stem cell-derived cardiomyocytes","volume":"552","author":"Gao","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"2026080621570297300_rbag103-B56","doi-asserted-by":"crossref","first-page":"C1326","DOI":"10.1152\/ajpcell.00196.2023","article-title":"The role of fibrosis in the pathophysiology of muscular dystrophy","volume":"325","author":"Mogharehabed","year":"2023","journal-title":"Am J Physiol-Cell Physiol"},{"key":"2026080621570297300_rbag103-B57","doi-asserted-by":"crossref","first-page":"15753","DOI":"10.1096\/fj.202000994RR","article-title":"The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury","volume":"34","author":"Edwards","year":"2020","journal-title":"FASEB J"},{"key":"2026080621570297300_rbag103-B58","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/cbin.10725","article-title":"The role of TGF-\u03b21 during skeletal muscle regeneration","volume":"41","author":"Anonymous","year":"2017","journal-title":"Cell Biol Int"},{"key":"2026080621570297300_rbag103-B59","doi-asserted-by":"crossref","first-page":"e20190103","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor\u2013\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"key":"2026080621570297300_rbag103-B60","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biocel.2018.04.002","article-title":"Perivascular cell \u03b1v integrins as a target to treat skeletal muscle fibrosis","volume":"99","author":"Prazeres","year":"2018","journal-title":"Int J Biochem Cell Biol"},{"key":"2026080621570297300_rbag103-B61","doi-asserted-by":"crossref","first-page":"1436072","DOI":"10.3389\/fphar.2024.1436072","article-title":"Trimetazidine improves angiogenesis and tissue perfusion in ischemic rat skeletal muscle","volume":"15","author":"Pan","year":"2024","journal-title":"Front Pharmacol"},{"key":"2026080621570297300_rbag103-B62","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00441-018-2955-2","article-title":"Skeletal muscle fibrosis: an overview","volume":"375","author":"Mahdy","year":"2019","journal-title":"Cell Tissue Res"}],"container-title":["Regenerative Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/rb\/advance-article-pdf\/doi\/10.1093\/rb\/rbag103\/68685062\/rbag103.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag103\/68685062\/rbag103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/rb\/article-pdf\/doi\/10.1093\/rb\/rbag103\/68685062\/rbag103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T01:57:15Z","timestamp":1786067835000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rb\/article\/doi\/10.1093\/rb\/rbag103\/8723884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1093\/rb\/rbag103","relation":{},"ISSN":["2056-3418","2056-3426"],"issn-type":[{"value":"2056-3418","type":"print"},{"value":"2056-3426","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"rbag103"}}